ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTREACCS in the chemical development environment. 3. Graphically nonequivalent representations of molecules and reactionsJohn E. Mills and Barbara BaughmanCite this: J. Chem. Inf. Comput. Sci. 1990, 30, 4, 431–435Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/ci00068a014https://doi.org/10.1021/ci00068a014research-articleACS PublicationsRequest reuse permissionsArticle Views26Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts

ChemInformVolume 21, Issue 5 Reviews ChemInform Abstract: Catalysis from the Perspective of an Organic Chemist: Common Problems and Possible Solutions C. A. MARYANOFF, C. A. MARYANOFF McNeil Pharm., Spring House, PA, USASearch for more papers by this authorJ. E. MILLS, J. E. MILLS McNeil Pharm., Spring House, PA, USASearch for more papers by this authorR. C. STANZIONE, R. C. STANZIONE McNeil Pharm., Spring House, PA, USASearch for more papers by this authorJ. T. JUN. HORTENSTINE, J. T. JUN. HORTENSTINE McNeil Pharm., Spring House, PA, USASearch for more papers by this author C. A. MARYANOFF, C. A. MARYANOFF McNeil Pharm., Spring House, PA, USASearch for more papers by this authorJ. E. MILLS, J. E. MILLS McNeil Pharm., Spring House, PA, USASearch for more papers by this authorR. C. STANZIONE, R. C. STANZIONE McNeil Pharm., Spring House, PA, USASearch for more papers by this authorJ. T. JUN. HORTENSTINE, J. T. JUN. HORTENSTINE McNeil Pharm., Spring House, PA, USASearch for more papers by this author First published: January 30, 1990 https://doi.org/10.1002/chin.199005336Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume21, Issue5January 30, 1990 RelatedInformation

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTREACCS in the chemical development environment. 1John E. Mills, Cynthia A. Maryanoff, Kirk L. Sorgi, Lorainne Scott, and Robin StanzioneCite this: J. Chem. Inf. Comput. Sci. 1988, 28, 3, 153–155Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://doi.org/10.1021/ci00059a006RIGHTS & PERMISSIONSArticle Views27Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (416 KB) Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTREACCS in the chemical development environment. 2. Structure and construction of proprietary databasesJohn E. Mills, Cynthia A. Maryanoff, Kirk L. Sorgi, Robin Stanzione, Lorraine Scott, Leonard Herring, Julie Spink, Barbara Baughman, and William BullockCite this: J. Chem. Inf. Comput. Sci. 1988, 28, 3, 155–159Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://doi.org/10.1021/ci00059a007RIGHTS & PERMISSIONSArticle Views26Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (630 KB) Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of amines with methylene chloride. Evidence for rapid aminal formation from N-methylenepyrrolidinium chloride and pyrrolidineJohn E. Mills, Cynthia A. Maryanoff, David F. McComsey, Robin C. Stanzione, and Lorraine ScottCite this: J. Org. Chem. 1987, 52, 9, 1857–1859Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/jo00385a038https://doi.org/10.1021/jo00385a038research-articleACS PublicationsRequest reuse permissionsArticle Views2438Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

ChemInformVolume 18, Issue 40 Heterocyclic Compounds ChemInform Abstract: The Reaction of Amines with Methylene Chloride. Evidence for Rapid Aminal Formation from N-Methylenepyrrolidinium Chloride and Pyrrolidine. J. E. MILLS, J. E. MILLS Dep. Appl. Chem., Fac. Sci. Technol., Keio Univ., Yokohama 223Search for more papers by this authorC. A. MARYANOFF, C. A. MARYANOFF Dep. Appl. Chem., Fac. Sci. Technol., Keio Univ., Yokohama 223Search for more papers by this authorD. F. MCCOMSEY, D. F. MCCOMSEY Dep. Appl. Chem., Fac. Sci. Technol., Keio Univ., Yokohama 223Search for more papers by this authorR. C. STANZIONE, R. C. STANZIONE Dep. Appl. Chem., Fac. Sci. Technol., Keio Univ., Yokohama 223Search for more papers by this authorL. SCOTT, L. SCOTT Dep. Appl. Chem., Fac. Sci. Technol., Keio Univ., Yokohama 223Search for more papers by this author J. E. MILLS, J. E. MILLS Dep. Appl. Chem., Fac. Sci. Technol., Keio Univ., Yokohama 223Search for more papers by this authorC. A. MARYANOFF, C. A. MARYANOFF Dep. Appl. Chem., Fac. Sci. Technol., Keio Univ., Yokohama 223Search for more papers by this authorD. F. MCCOMSEY, D. F. MCCOMSEY Dep. Appl. Chem., Fac. Sci. Technol., Keio Univ., Yokohama 223Search for more papers by this authorR. C. STANZIONE, R. C. STANZIONE Dep. Appl. Chem., Fac. Sci. Technol., Keio Univ., Yokohama 223Search for more papers by this authorL. SCOTT, L. SCOTT Dep. Appl. Chem., Fac. Sci. Technol., Keio Univ., Yokohama 223Search for more papers by this author First published: October 6, 1987 https://doi.org/10.1002/chin.198740165AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume18, Issue40October 6, 1987 RelatedInformation

AbstractDurch Umaminierung von Dimethylthioformamid (I) mit sekundä‐ ren Aminen (II) sind weitere Thioformamide (‐III) zugänglich.

AbstractDie Thioharnstoffe (I) werden durch H2O2 in Gegenwart von Natriummolybdat zu den Sulfonsäuren (II) oxidiert, die mit den Aminen (III) zu den Guanidinen (IV) reagieren.

AbstractAus den N‐Methyl‐benzinmidoylchloriden (l).

4-(Diphenylmethyl)-1-piperidinemethanimine (1) is a potent oral gastric antisecretory agent in rats but contains a strong anticholinergic component. Since a nonanticholinergic gastric antisecretory drug would be useful in the treatment of peptic ulcer disease, a program was initiated by us to find such an agent based on 1. Compound 1 contains structural elements common to the anticholinergics atropine and homatropine. Studies on the structure-activity relationships of these compounds and their derivatives have revealed certain modifications that diminish or abolish anticholinergic activity. The application of these modifications to the design of analogues of 1 afforded an antisecretory compound, 4-(diphenylmethyl)-1-[(octylimino)methyl]piperidine (3h, fenoctimine), which exhibited no anticholinergic activity. Fenoctimine is undergoing clinical trial as a gastric antisecretory drug.