Human T-lymphotropic virus type III (HTLV-III/LAV) has been shown to contain at least four extra genes in addition to the three essential genes (gag, pol, env) for replication of most retroviruses. These genes are expressed by complex splicing mechanisms and utilization of overlapping reading frames. We now demonstrate that there is an eighth gene which encodes a protein which is immunogenic and recognized by sera of some HTLV-III seropositive people. The gene is highly conserved among all known HTLV-III isolates and exhibits a polymorphism at the 3' end which distinguishes several molecular clones of the HTLV-IIIB cell line from those of other HTLV-III/LAV isolates. The function of this gene is unknown.
David Marquis合作论文数67Junming Le合作论文数58Jan Vilcek合作论文数58Peter Daddona合作论文数58Scott A. Siegel合作论文数56Scallon B合作论文数21Lester T. May合作论文数9george a heavner合作论文数9Uma Santhanam合作论文数9
Pravin B. Sehgal合作论文数Department of Cell Biology & Anatomy, New York Medical College8
Thomas Nesspor合作论文数8
Stephen Bradley Tatter合作论文数Department of Neurosurgery, Wake Forest University Health Sciences8Chichi Huang合作论文数7Nancy T. Chang合作论文数7KA Reimann合作论文数6
Marc Feldmann合作论文数Kennedy Institute of Rheumatology, Medical Sciences Division, University of Oxford;Somerville College, University of Oxford6
Masayori Inouye合作论文数Center for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey;Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey6Han Trinh合作论文数5Chanda P K合作论文数4Looney J E合作论文数4P Daddona合作论文数4Albert F Lobuglio合作论文数4M. Nedelman合作论文数4Muhamad B Khazaeli合作论文数4peter dadonna合作论文数3Mt Nakada合作论文数3R C Gallo合作论文数3C Wagner合作论文数3
Naglaa H Shoukry合作论文数Hop St Luc, CRCHUM3
Joern Schmitz合作论文数3
Tam Susan H合作论文数3Arash Grakoui合作论文数3
Nina Bhardwaj合作论文数Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine, Mount Sinai;Vaccine and Cell Therapy Laboratory, Icahn School of Medicine, Mount Sinai3Fionula M. Brennan合作论文数3David Shealy合作论文数3R Derita合作论文数3
Harlan Weisman合作论文数Duke Clinical Research Institute3Ernst Peter Rieber合作论文数3L. K. Sun合作论文数3MA Lifton合作论文数2M R Dalesandro合作论文数2M J Kuroda合作论文数2Bernard M Flynn合作论文数2Stephen R. Petteway合作论文数2M. A. Simon合作论文数2Pranab K. Chanda合作论文数2Ky Pak合作论文数2LK SUN合作论文数2MF MCALEER合作论文数2
