Dr. Utz is professor emeritus at Georgetown University, where he served as dean of the School of Medicine. From 1952 to 1965, he was chief of the Infectious Diseases Service at the National Institutes of Health. He then was chief of the Division of Immunology and Infectious Diseases, Medical College of Virginia, Richmond. He has also been a consultant for various companies and for several nations, including El Salvador, Costa Rica, and Korea. He is president emeritus of the National Foundation for Infectious Diseases, which he co-founded in 1973.

Aspergillus flavus endocarditis developed in a 13 year old girl after mitral valve replacement. Thirty-nine other cases of Aspergillus species endocarditis were found in the medical literature. Twenty-nine of these infections occurred in postcardiac surgery patients. Fever was the most common presenting manifestation (35 patients). Cardiac murmurs were present in 25. Lesions were in the left side of the heart in 38 (95 per cent), and there were major arterial emboli in 33 (83 per cent).

But better than be able, do decline. For the dangers of digging are graphically defined in the paper in this issue (page 507) by Werner and his associates. In addition to Prudence1 the Steward of the students would need wisdom to weigh, as physicians must in other contexts, the risks of the procedure against the benefit or the knowledge to be gained. But what an apposition of talents: the archeologic wisdom to predict the value from the diggings and the epidemiologic wisdom to predict the likelihood of Coccidioides immitis in the soil The conventional wisdom would have had it that . . .

This week flucytosine (5-FC) will be released to the medical profession. It is the first new drug in approximately 15 years with activity in the systemic mycoses. The occasion prompts the following observations and caveats.The range of infections treatable with 5-FC is remarkably limited: from animal and human studies candida species and Cryptococcus neoformans. A less frequently pathogenic yeast, Torulopsis glabrata, is sensitive in vitro, and success has been claimed in three of five cases reported so far. In animal infections chemotherapeutic activity has been found against Aspergillus fumigatus, but no clinical data encountered so far . . .

"Personnel Tuberculosis Control Program in Medical Institutions*." American Review of Respiratory Disease, 104(3), pp. 463–465

At this writing we are in the midst of the Hong Kong flu epidemic; it is difficult to view viruses as anything other than unpleasant enemies. What a mystery that a particle so small can by replicating (the new term) produce so devastating an illness in such vast numbers of people! The Molecular Basis of Virologyis not at all concerned with disease; it does not regard influenza virus A2/ Hong Kong a noxious agent, and attempts to dispel some of the mysteries that surround these microorganisms. Anyone who is disposed to look beyond disease can find in this book (in authorative fashion) a revelation of the physicochemical forces that characterize these agents. Although the book is not in historical perspective, there are painstaking descriptions of the epochal experiments which delineated new concepts and opened ways to new work. Among these are the bacterial transformation by infectious deoxyribonucleic acid by

SINCE the days of the early Christian church Dorothy has been the patron saint of gardeners. Although she is probably seldom invoked today, the gardener in whom the occupational disease, sporotrichosis, develops and those who attend him may have wished for deliverance. A painless but persistent ulcer on the finger, with subsequent red or draining areas centrally, usually does not evoke a prolonged history taking to suggest the diagnosis. Contrariwise, who is left these days who cannot give a positive history of recently sprinkling the sphagnum moss, trimming the barberry or cutting the roses? The abscess, if it does not . . .

s1 May 1968Current Status of the Chemotherapy of the Systemic Mycoses.John P. Utz, M.D., F.A.C.P.John P. Utz, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1177_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite the wide variety of antibiotic agents effective against bacterial diseases by the year 1957, no agent was available for the systemic mycoses until amphotericin B became available that year. Early experience with this drug was summarized in a presentation before the 40th Annual Session of the American College of Physicians in 1959. Since that time the serious toxic effects, especially on the bone marrow and the kidney, and the unpleasant general reactions in the form of nausea, vomiting, fever, and chills that the patient experiences have led to continuing search for better agents. One of these, the SFD preparation... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John P. Utz, M.D., F.A.C.P.Affiliations: Richmond, Virginia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFluorinated Pyrimidines and Their NucleosidesPulmonary Candidiasis Treated with 5-FluorocytosineChapter 13. Antifungal AgentsVariant Forms of Pulmonary CryptococcosisBAYARD TYNES, M.D., F.A.C.P., KATHLEEN N. MASON, M.S., ANNE E. JENNINGS, JOHN E. BENNETT, M.D., F.A.C.P. 1 May 1968Volume 68, Issue 5Page: 1177-1178KeywordsAntibioticsBacterial diseasesBone marrowChemotherapyDrugsFeversKidneysNauseaSystemic mycosesVomiting ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...

WILSON, DANA E. M.D.2; MANN, JOHN J. M.D.3; BENNETT, JOHN E. M.D.3; UTZ, JOHN P. M.D. Author Information