BACKGROUND:Blood culture (BCx) diagnostic stewardship is essential for reducing unnecessary treatments, minimizing false-positive results, and improving patient outcomes and hospital resource utilization. The objective of this study was to compare the effectiveness of diagnostic stewardship interventions on BCx utilization in three emergency departments (ED). METHODS:We used a quasi-experimental pre-/post-intervention study to compare BCx rates (BCx/100 ED visits) between December 1, 2020, and February 29, 2024 before and after the implementation of a BCx algorithm and electronic health record (EHR) modifications at one large academic ED and level 1 trauma center, and two EDs at academic-affiliated community hospitals. A sample of visits with a BCx order were audited in one academic ED and one academic-affiliated ED, and summary data on indication appropriateness were provided to respective leadership. In the academic ED, there was weekly provider led audit and feedback on 3478 ED visits. In one academic-affiliated ED, one pharmacist reviewed five visits weekly (100 total) for appropriateness. The second academic-affiliated ED served as a control and did not receive any feedback on BCx utilization. Each ED's BCx rates were analyzed using interrupted time series models. Incidence rate ratios (IRR) compared BCx rates before and after the interventions. RESULTS:A total of 211,950 BCxs over 572,776 ED visits were included in the analysis. The academic ED saw a 25 % decrease in BCx rate with IRR 0.80 (95 % CI 0.74, 0.86, p-value 0.01). The first academic-affiliated ED experienced a 0.8 % decrease in BCx rate with IRR 1.1 (95 % CI 1.01, 1.19, p-value 0.02). No change was observed in the second academic-affiliated ED. CONCLUSIONS:Decreased BCx rates occurred only after direct audit and feedback and EHR modifications. Both the academic ED and first academic-affiliated ED saw a drift back towards pre-intervention BCx rates after the intervention.

Abstract Background Blood cultures (BCx) are commonly ordered for patients at low risk of bacteremia. Liberal ordering can increase false-positive results due to contamination, along with increasing length of stay, excess antibiotics, and unnecessary diagnostic procedures. We implemented an algorithm for appropriate blood culture obtainment (Figure 1) in an academic tertiary care emergency department (ED) and assessed the intervention’s impact on various operational, clinical, and safety metrics.Figure 1:ED Blood culture algorithm Methods We performed a prospective cohort study in the Duke University Hospital ED from 12/2022 to 3/2023 using historical controls from 12/2020-11/2022. The BCx algorithm was disseminated in-person, electronically, and accessible online. Weekly chart review of all eligible patients for algorithm adherence was completed by 7 ED clinicians with monthly feedback provided to all ED providers. We defined a BCx event as 1 or more BCx sets within 24 hours. We excluded patients < 18 years, absolute neutrophil count < 500 109/L, and heart and lung transplant recipients. We measured BCx order volume, indication, algorithm adherence, BCx positivity rate, antibiotic days of therapy (DOT), and 30-day hospital readmission. Results Average monthly BCx volume was 1387 pre-intervention compared to 1226 post-intervention (p= 0.046). An increase in culture positivity was see post-intervention with a rate of 13.9% compared to 11.23% in the pre-intervention group (Figure 2, p< 0.001). The majority of the 2168 BCx adhered to the algorithm. (Figure 3). The most common reasons for non-adherence were isolated fever or leukocytosis (29%), non-severe community-acquired pneumonia or healthcare-associated pneumonia (6.9%) and non-severe cellulitis (4%). No change in DOT (786 vs. 783 days of therapy per 1000 patient days, p-value 0.85) (Figure 4) or monthly 30-day hospital readmission (21.1% vs 19.6%, p-value 0.30) was observed.Figure 2:Blood cultures drawn per month and % appropriate pre/post-intervention (N=2168)Figure 3:Algorithm Adherent vs. Algorithm Non-Adherent blood cultures per month (N=2168)Figure 4:Emergency Department anti-bacterial days of antibiotic therapy per 1000 patient days Conclusion Introduction of a BCx algorithm in an academic tertiary care ED, resulted in a decrease in BCx volume, increase in BCx positivity rate, and no increase in DOT or readmission was observed. (Table 1)Table 1:Blood culture volume, positivity rate, days of antibiotic therapy, and 30-day readmission Disclosures Jessica Seidelman, MD, MPH, Uptodate: content editor for pelvic osteomyelitis page

Among emergency department patients with chest pain, more than 50% patients are diagnosed with a noncardiac condition and 5.1% are diagnosed with acute coronary syndrome (ACS). ACS is suggested by a suspicious history (chest pain characteristics and risk factors) and either electrocardiogram or troponin abnormalities consistent with myocardial ischemia. In the absence of an indication for emergent reperfusion, risk stratification is often used in the emergency department to identify patients who would benefit from advanced cardiac testing or intervention.

Abdominal pain is a common and challenging chief complaint. Signs and symptoms often overlap, and the differential includes both serious and self-limited conditions. This article reviews the differential diagnoses for adult patients with abdominal pain, distinguishing features of the history and physical examination, and diagnostic tests used to identify or exclude serious illness.