A new, efficient method has been developed for the synthesis of BMS-337197, a novel IMPDH inhibitor. The new method uses the readily available 2-bromo-1-(2-nitrophenyl) ethanone as a starting reagent and provides BMS-337197 in 9 steps in 55% overall yield on a multigram scale.
d(3)-Cerivastatin was synthesized as an internal standard for use in a LC/MS/MS method developed for the simultaneous quantitative determination of the drug in human serurn. d(3)-Cerivastatin was efficiently prepared on large scale from d(3)-iodomethane using improved procedures. Copyright (c) 2006 John Wiley & Sons, Ltd.
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