The FASEB JournalVolume 6, Issue 8 p. 2614-2615 50 Years Ago A fragment of metabolic prehistory Jay Tepperman, Corresponding Author Jay Tepperman n/a@.dne To whom requests for a pertinent bibliography may be addressed, at: 7684 Stonehedge Lane, Manlius, NY. 13104, USA.Search for more papers by this authorJohn R. Brobeck, John R. BrobeckSearch for more papers by this author Jay Tepperman, Corresponding Author Jay Tepperman n/a@.dne To whom requests for a pertinent bibliography may be addressed, at: 7684 Stonehedge Lane, Manlius, NY. 13104, USA.Search for more papers by this authorJohn R. Brobeck, John R. BrobeckSearch for more papers by this author First published: 01 May 1992 https://doi.org/10.1096/fasebj.6.8.1592212AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume6, Issue8May 1992Pages 2614-2615 RelatedInformation

Electrical stimulation through a bipolar electrode introduced into either the left or right lateral hypothalamus of anesthetized cats by means of a stereotaxic instrument elicited stimulus-bound phasic antral contractions in the anesthetized cat's stomach of much greater force than recorded under basal conditions. There was no change in gastric acid output. The response was abolished by bilateral cervical vagotomy or atropine. Stimulation during an intravenous infusion of pentagastrin did not alter the gastric acid secretory response. A hypothalamic vagal and cholinergic excitatory gastric antral motor pathway to the stomach has been demonstrated, independent of an acid secretory response.

The effects on food intake, of injections into the lateral ventricle of Ca++, Mg++ or equimolar mixtures of the 2 ions have been studied in pigs. The chloride salts were made up in normal saline which together with 1.35 percent NaC1 was used as a control injection. Dosages of 12.5 mumoles, 25 mumoles, or 50 mumoles either Ca++ or Mg++ elicited increased food intake in the 30 min following the injection and there was a predominantly linear feeding response to increasing concentration of the two ions. Ca++ was more effective in eliciting increased food intake than Mg++. Equimolar mixtures of Ca++ and Mg++ of 6.5 + 6.5 mumoles, 12.5 + 12.5 mumoles or 25 + 25 mumoles also increased food intake linearly and the mixture of ions was more effective than equivalent concentrations of Ca++ or Mg++ alone. No antagonism between Ca++ and Mg++ was seen with respect to food intake. Intraventricular injections of 16 mumoles of sodium pentobarbital also elicited increased food intake in the 30 min following injection. It is suggested that the ions and the barbiturate probably act by deression of periventricular neurons, particularly in the medial hypothalamus which is adjacent to the third ventricle.

Rats were prepared with chronic ig and iv catheters and fed ad libitum. The effect of ig loading of hypertonic glucose or NaCl on food intake was studied with and without concomitant iv infusion of distilled water. With water infusion, the depression of food intake induced by ig glucose was not affected, while the depression induced by ig NaCl was significantly attenuated. It was concluded that the depression of food intake following ig glucose is not the result of osmotic stress.

ARTICLESEffect of body fluid disturbance on feeding in the ratTH Yin, CL Hamilton, and Brobeck JRTH Yin, CL Hamilton, and Brobeck JRPublished Online:01 Apr 1970https://doi.org/10.1152/ajplegacy.1970.218.4.1054MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByRestricting fluid intake during a single meal did not affect food intake in older adultsAppetite, Vol. 41, No. 1Short-term control of feeding: Limitation of the glucostatic theoryBrain Research Bulletin, Vol. 17, No. 5GLUCOPRIVATION AND THE GLUCOPRIVIC CONTROL OF FOOD INTAKEEffect of changes in pH, in osmolarity, or in temperature on food intakeThe American Journal of Clinical Nutrition, Vol. 42, No. 5Body Hydration and Haemolymph Osmolality Affect Feeding and its Neural Correlate in the Terrestrial Gastropod, Limax MaximusJournal of Experimental Biology, Vol. 118, No. 1Gastrointestinal factors in hunger and satietyNeuroscience & Biobehavioral Reviews, Vol. 6, No. 2Control of body fluids and saline intake in hamstersBehavioral and Neural Biology, Vol. 30, No. 1Hormones and hedonics cholecystokinin and taste: A possible behavioral mechanism of actionPhysiology & Behavior, Vol. 25, No. 1Control of feeding during saline consumption and fluid deprivation in hamstersPhysiology & Behavior, Vol. 22, No. 5Predigestion and suppression of food intake by gastric loadsPhysiology & Behavior, Vol. 21, No. 4Caloric compensation to gastric loads in rats with hypothalamic hyperphagiaPhysiology & Behavior, Vol. 13, No. 2Specificity of behavioral regulationPhysiology & Behavior, Vol. 12, No. 5Liquid intake, initiation and amount of eating as determined by osmolality of drinking liquidsPhysiology & Behavior, Vol. 7, No. 2HEPATIC RECEPTORS AND THE NEUROPHYSIOLOGICAL MECHANISMS CONTROLLING FEEDING BEHAVIOR More from this issue > Volume 218Issue 4April 1970Pages 1054-1059 Copyright & PermissionsCopyright © 1970 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1970.218.4.1054PubMed5435403History Published online 1 April 1970 Published in print 1 April 1970 Metrics

At an ambient temperature of 25°C, selective cooling of the area preoptica medialis to 24° ± 1°C produced a significant decrease in food intake together with hyperthermia. Heating the same area to 43° ± 1°C resulted in the opposite effects. At an ambient temperature of 35°C, heating the area preoptica medialis to 43°C resulted in a decrease in food intake despite concomitant hypothermia.

Rats with lesions placed bilaterally in the region of the anterior hypothala-mus, when compared with control rats, eat more food in the heat, eat less food at cool and cold temperatures, and run less in response to cold stress. In addition, it was demonstrated that abnormalities in temperature regulation following the lesions are not transitory, but are clearly evident 9 months after the operations.

Annals of the New York Academy of SciencesVolume 131, Issue 1 p. 583-592 CONTROL OF FOOD INTAKE IN NORMAL AND OBESE MONKEYS* C. L. Hamilton, C. L. Hamilton Veterans Administration Hospital, Coatesville, Pa.Search for more papers by this authorJohn R. Brobeck, John R. Brobeck University of Pennsylvania, Philadelphia, Pa.Search for more papers by this author C. L. Hamilton, C. L. Hamilton Veterans Administration Hospital, Coatesville, Pa.Search for more papers by this authorJohn R. Brobeck, John R. Brobeck University of Pennsylvania, Philadelphia, Pa.Search for more papers by this author First published: October 1965 https://doi.org/10.1111/j.1749-6632.1965.tb34821.xCitations: 13 * This work was supported in part by Research Grant M-3327 from the United States Public Health Service. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume131, Issue1Adipose Tissue Metabolism and ObesityOctober 1965Pages 583-592 RelatedInformation

The lower brain stem was explored for cardiovascular and respiratory responses by means of local diathermy in 36 urethane-anesthetized and 48 unanesthetized, decerebrate cats. In the lateral reticular formation, extending from the level of the rostral end of the inferior olivary nuclei to the most caudal portion of the medulla oblongata, localized heating decreased both rate and tidal volume of respiration, with marked bradycardia, a slight change in systolic blood pressure, and some increase in pulse pressure. Electrical stimulation of the same area usually induced forceful inspiration associated with no cardiovascular response. The thermally induced bradycardia, but not the decrease of respiration, was abolished by vagotomy or by the administration of atropine. The same diathermy applied locally to the rostral hypothalamus in the same cats evoked mainly acceleration of respiration with little cardiovascular reaction. The present experiments suggest that the lateral reticular formation of the medulla is as sensitive to thermal stimulation as is the rostral hypothalamus. The significance of the medullary thermal sensitivity, however, is not clear.

The behavioral effects of lesions in the region of the ventromedial nuclei of the hypothalamus were studied in 7 monkeys. These Ss along with unoperated controls were utilized in various tests investigating parameters of food intake and weight gain; observations were made on the effects of the lesio

Rats with lesions of the anterior midline hypothalamus were studied in reference to the regulation of body temperature and food intake. The data support the thesis that this area of the hypothalamus is involved not only with normal regulation of body temperature but also with food intake, and thus indirectly with internal heat production.