Angermeier, Paul L., 171 Authman, Mohammad N., 425 Beets, Jim, 109 Bejda, Alien J., 321 Borgstrem, Reidar, 247 Boujard, Thierry, 235 Bouton, Niels, 1 Bowers, Eric, 65 Brabrand, Age, 247 Browman, Howard I., 181 Bruton, Michael N., 379 Castonguay, Martin, 393 Chang, Ching-Fong, 309 Coates, David.. 51 Colin, Patrick L., 357 Davis, Michael W., 421 Dugatkin, Lee A., 265 D’Amours, Denis, 393 Ebersole, John, 109 Eggold, Bradley T., 139 Fox, Michael G., 159 Fricke, Hans, 329 Gerstner, Cynthia L., 219 Godin, Jean-Guy J., 265 Goldschmidt, Yijs, 1 Goto, Akira, 119 Goudswaard, Kees, 1 Hastings, Philip A., 213 Hissmann, Karen, 329 Hu, Hung-Jen, 309 James, Nicholas P.E., 379 Jansen, Wolfgang A., 287 Kalinin. Sergey V., 401 Kaufman, Les, 109 Keast, Allen, 159 Keenleyside, Miles H.A., 207 Khallf, Elsayed A., 425 Kinas, Natalya M., 401 Kramer, Vincent, J., 315 Kwak, Thomas J., 127 Lawrence, Bonnie J., 103 Leslie, Mitchell A., 29 Mackay, William C., 287 Mackereth, Robert W., 207 McIvor, Carole C., 109 Motta, Philip J., 139 Moyle, Marilyn A., 102,138,1%, 264,286 Moyle, Peter B., 102, 138,264,286 Newman, Michael C., 315 Oijen van, Martien, 1 OIla, Bori L., 421 Ormond, Rupert F.G., 79,305 Owen, Roger, 65 O’Brien, W. John, 181 Parrish, Julia K., 2.57 Phelan, Beth A., 321 Quinitio, Gerald F., 119 Roberts, Callurn M., 79, 305 Rostomova, Svetlana S., 401 Russell, Nigel R., 277 Sakashita, Horoko, 95 Shephard, Kerry L., 409 Skelly, Thomas M., 127 Smith, R. Jan F., 103 Solheim, Johan Trygve, 247 Stiassny, Melanie L.J., 219 Studholme, Anne L., 321 Takahashi, Hiroya, 119 Tang, Hung-Chi, 309 Treasurer, James W., 65 Ultsch, Gordon R., 315 Van Puymbroeck, Sylvain, 197 Vanderborght, Oscar L.J., 197 Varnavsky, Vladimir S., 401 Wanink, Jan, 1 Winemiller, Kirk O., 29 Witte, Frans, 1 Witters, Hilda E., 197 Witte-Maas. Els, 1 Wootton, Robert J., 277 Wrathall, Timothy J., 305

In this prospective study of chronic active liver disease, we compared the assessment of hepatic histology in samples obtained by peritoneoscopy with directed liver biopsy and blind percutaneous liver biopsy in 23 cases (22 patients, one patient studied twice). In blinded fashion, a pathologist assessed all specimens for evidence of cirrhosis and degree of necroinflammatory change. Two clinicians independently reviewed clinical and laboratory findings in both sets of biopsies. Each committed in writing recommendations regarding immunosuppressive therapy, follow-up interval, and rebiopsy date. The final diagnosis differed from that made by percutaneous and directed biopsy in 2 of 23 (9%) and 1 of 23 (4%) cases, respectively. Six cases of cirrhosis were correctly diagnosed by both biopsy methods, but only four of the six cirrhotic cases were diagnosed by gross peritoneoscopic findings. In only 2 of 23 (9%) cases was there disagreement in the degree of necroinflammatory change between the blind and directed biopsies that affected treatment recommendations. We conclude that blind percutaneous biopsy adequately diagnoses and monitors activity in viral chronic hepatitis for treatment purposes.

toneal isotopic study was performed to assess shunt patency and was consistent with nonfunction or occlusion.Treatment with spironolactone induced subsequent diuresis.As noted in a recent review,• increase in ascites is occasionally observed after endoscopic variceal sclerotherapy.A variety of mechanisms are suggested, including increased hepatic lymphatic, mesenteric lymphatic, or venous pressures as a result of shunting from the occluded venous collaterals back into intraabdominal channels.Increased thoracic central pressure resulting from injection effects (cephalad flow, altered pulmonary circulatory dynamics) could conceivably playa role.We advise cautious observation in patients with peritoneojugular shunts undergoing sclerotherapy, and suggest that shunting may be wiser to perform after several sessions of sclerotherapy, a point when major circulatory changes from injection are probably less likely to occur.

The most comfortable gas for peritoneoscopy has been the subject of debate. We subjected 46 patients to double-blind comparison of carbon dioxide and nitrous oxide during initial pneumoperitoneum. The discomfort from local anesthesia was similar in both patient groups. The patient's and the physician's assessment of discomfort during gas insufflation showed that carbon dioxide was more uncomfortable as perceived by the patient (p = 0.02), the physician (p = 0.0006), and objectively assessed by degree of abdominal splinting (p = 0.006). The presence of intraabdominal adhesions had no relationship to discomfort. We conclude that nitrous oxide is more comfortable for institution of pneumoperitoneum during peritoneoscopy under local anesthesia.

Embryos in specific stage of the estuarine teleost, Fundulus heteroclitus, were exposed to mercuric chloride (MC) and methylmercuric chloride (MMC) under several distinct treatment conditions. Four-eight cell stage eggs (0-day old) were exposed for 4 days (continuous), 2 days and one day to each mercury compound. One-day old (mid-blastula), 2-day old (mid-neurula) and 5-day old (beating heart) embryos were exposed 4 days to MC and MMC. Mortality for the four days immediately following the initiation of exposure was the embryonic response measured. Under most exposure conditions to the 4–8 cell eggs, progressive and significant reductions in survival were observed at all concentrations above 40 and 30 μgHg++l−1 as MC and MMC, respectively. Reducing the duration of exposure to 1 day most significantly increased the survival potential of the 4–8 cell eggs. For all exposure treatments to the 4–8 cell eggs, significant differences in survival, between eggs exposed to MC and MMC, were determined at 40, 60 and 80 μgHg++l−1, indicating the presence of compound-dependent response differences. In all cases demonstrating response differences between MC and MMC exposed embryos, survival was significantly lower following exposure to MMC. Survival of embryos was progressively increased when the initiation of continuous exposure (4 days) was delayed 1, 2 and 5 days after fertilization. As a result, compound-dependent response differences were progressively shifted to higher He++ concentrations. For both MC and MMC, survival of 1-day old embryos exposed for 4 days was greater than that of 0-day old eggs exposed for 1 day. Of the embryonic stages examined, it appears that the earlier cleavage stages are the most sensitive to mercury intoxication.

Melanosis involving the duodenum is extremely rare. We present endoscopic, microscopic, and histochemical studies of a patient with melanosis of the duodenum associated with a gastric ulcer and a folic acid deficiency. The pigment is similar to that observed in melanosis coli and histochemically does not stain like melanin or lipofuscin. The pigment disappeared with correction of the folate deficiency and healing of the gastric ulcer, suggesting a possible relationship with these entities.

American DocumentationVolume 17, Issue 1 p. 41-44 Brief Communication The SLIC index John R. Sharp, John R. Sharp ICI Fibres Limited Pontypool, Great BritainSearch for more papers by this author John R. Sharp, John R. Sharp ICI Fibres Limited Pontypool, Great BritainSearch for more papers by this author First published: January 1966 https://doi.org/10.1002/asi.5090170109Citations: 7AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume17, Issue1January 1966Pages 41-44 RelatedInformation