Analytical validation of the VHIO-YWBC protocol

Complete information of the Case cohort, with clinical features and results from the somatic mutation analysis

Diagnostic images of the PPBC from case #15 right breast

Table 1. Samples analyzed by NGS Table 2. VHIO-300 results from solid tumor Table 3. VHIO-YWBC results from BM positive for ctDNA

Sensitivity of the BM ctDNA detection assays.

Supplementary Table S1. Models, point mutations and CNA Supplementary Table S2. Differentially expressed genes, pathways and co-occurrence

RNA-seq analyses of global exon splicing events (S1); Cell line therapy sensitivities (S2); Hazard ratios for survival of patients with serous ovarian carcinomas associated with BRCA1 mutation, age at diagnosis and stage (S3); Characteristics of studies included in survival analysis from Fig. 5A (S4).