A 41-year-old woman was admitted to the hospital with severe uremia, hemolytic anemia, and thrombocytopenic purpura. Emergency hemodialysis with plasmapheresis was started in view of consideration of hemolytic uremic syndrome (HUS), which resulted in improvement of renal function and platelet count. Positive antineutrophil cytoplasmic autoantibody specific for myeloperoxidase (MPO-ANCA) suggested crescentic glomerulonephritis, which was pathologically evidenced by renal biopsy. The diagnosis of MPO-ANCA associated crescentic glomerulonephritis with autoimmune hemolytic anemia (AIHA) and thrombocytopenic purpura were confirmed. Three courses of steroid pulse therapy with heparin were successfully performed, followed by oral prednisolone and warfarin. Such a case has not been previously reported to our knowledge.

AbstractDurch Umsetzung der Ester oder Salze (I) mit den Aminen (II) (S‐ bzw. R‐ Konfiguration) in Diglyme, Tetrahydrofuran oder Alkohol entstehen die Schiffschen Basen, deren Reduktion mit Na‐boranat, anschließende Hydrolyse und Hydrogenolyse an Pd‐hydroxid/ Holzkohle zu den entsprechenden Aminosäuren (III) mit S‐ bzw. R‐Konfiguration führt.

Carbonyl compounds reaction with N- salicylideneglycinatoaquocopper /II/ syntheses of beta-hydroxy alpha-amino acid from glycine

DL-β-Hydroxyvaline was synthesized from sodium β,β-dimethylglycidate by aminolysis with benzylamine, followed by hydrogenolysis. N-Benzoyl-DL-β-hydroxyvaline was resolved by use of (−)-α-methylbenzylamine to yield (−)-N-benzoyl-β-hydroxyvaline. The configuration of VI was determined by converting it to methyl N-benzoyl-β-chlorovalinate (I) and subsequent hydrogenolysis of I yielded (−)methyl N-benzoylvalinate (II). From II, optically pure D-(−)-valine was obtained upon hydrolysis.

Optical resolution of epoxy derivative of butyric acid with brucine and configuration determination by treatment with ammonia