Breast cancer has become the first malignant tumor in women. Early detection and early treatment are the key to improve the prognosis of breast cancer patients. The key to the screening and diagnosis of breast cancer lies in the qualitative differential diagnosis of breast nodules. With the rapid development of MRI technology, especially the application of high field strength and ultra-high field strength, the role of breast MRI is increasingly prominent. MRI has the advantages of safety, no ionizing radiation, high resolution of soft tissue, high sensitivity and specificity for the diagnosis of early breast cancer. Multimodal imaging based on reinforcement learning and iron carbon nanoparticles plays an important role in the diagnosis of breast nodules. This paper first discusses the application of iron carbon nanoparticles and breast MRI multimodal imaging technology in tumor treatment, and then studies the application of iron carbon nanoparticles mediated multimodal imaging in the diagnosis of breast nodules through experimental methods. The experimental results show that multimodal imaging has a good effect in the diagnosis of breast nodules, which is helpful for the prevention and treatment of breast nodules.

We studied ZnO films grown by rf sputtering using Zn metal targets. During the growth the metal target can be at a metal or at an oxide mode, depending on oxidation of the target surface. At a metal mode the target surface is free of oxide, and the sputtering yield is higher, but deposited ZnO films show poor transistor characteristics. ZnO films deposited at an oxide mode show better transistor characteristics, but the sputtering yield is lower. In order to solve these problems, we supplied oxidizer gas as pulses during the growth. We hoped that the target condition could be controlled by varying parameters of the pulses. Our ZnO was grown at 450 degrees C using CO2 or O-2 as an oxidizer. After sputtering growth ZnO films were annealed in mixture of CO2 and H-2 at 400 degrees C. With these methods, bottom-gate ZnO thin-film transistor showed 6.5 cm(2)/Vsec mobility, 5 c 106 on/off ratio, and 1 5V threshold voltage. (C) 2017 The Ceramic Society of Japan. All rights reserved.

ZnO thin-film transistor (TFT) grown by rf magnetron sputtering in Ar/O2 atmosphere shows inferior turn-off characteristics compared to ZnO TFT grown by other methods. We thought that reactions between Zn and O2 might produce defects responsible for the poor turn-off behavior. In order to solve this problem, we studied sputtering growth in Ar/CO2 atmosphere at 450°C. During sputtering growth, we modulated substrate dc bias to control ion supply to the substrate. After growth ZnO was annealed in CO2 and O2 gas. With these methods, our bottom-gate ZnO thin-film transistor showed 4.7 cm2/Vsec mobility, 4×106 on/off ratio, and -2 V threshold voltage.

ISL1 is a LIM homeodomain protein that plays an important role in insulin gene transcriptional activation and islet cell formation. BETA2 is a transcription factor in the basic helix–loop–helix (bHLH) family, which activates expression of tissue-specific genes in several developmental systems. In this study, we investigated the functional and physical interactions of ISL1 and BETA2 in promoting insulin gene transcription in non-β cells. Using the luciferase assay, we demonstrated that ISL1 and BETA2 could activate insulin gene transcription synergistically. Co-immunoprecipitation also supported that ISL1 and BETA2 appear in one complex and this physical interaction mediates the synergy between these two proteins.