Background: Electroacupuncture (EA) has been observed to exerts in inflammatory pain. However, the invasiveness of EA may bring risk of infection. Transcutaneous electrical acupoint stimulation (TEAS)with similar parameters as EA without the risk of infection. Previous studies have shown that TEAS treatment can alleviate postoperative pain. However, its analgesic role in inflammatory pain has not been investigated. Methods: Complete Freund’s adjuvant (CFA)was injected into the male Sprague‐Dawley of rats to generate an inflammatory model. EA or TEAS treatment at the Zusanli (ST36) and Sanyinjiao (SP6) acupoints was given 4 days of CFA injection of mechanical and thermal sensitivity were determined. Microdialysis was performed before and after EA or TEAS. Adenosine concentration of dialysates as measured by high performance liquid chromatography. Results: TEAS treatment showed similar analgesic effects to EA treatment as assessed of rat’s paw withdrawal latency in response to mechanical and thermal stimulation. EA treatment significantly elevated adenosine concentration for at least 30 minutes, while TEAS induced a significant adenosine increase with similar amplitude over 60 minutes. Conclusion: TEAS may be a more convenient and more effective substitute for EA in inflammatory pain treatment.