Wound closure is critical for the care of wounds by preventing foreign matter entry and supporting healing. Failure of wound closure because of mechanical compromise or inflammation can lead to failure of effective apposition of tissues and manifest in delayed healing and even death, depending on the site of the wound. Therefore, a platform capable of identifying inflammation as well as delivery of therapeutics, including chemical, biological, and cellular therapies, could transform our capacity to effectively sense potential failure as well as maximize healing. Here, we report the development of a decellularized gut suture platform capable of sensing inflammation as well as delivering a broad array of therapeutics, including small molecules, monoclonal antibodies, and cell-based therapeutics. We demonstrate the mechanical and biological functionalities of our platform in rodents and pigs. We anticipate that this platform could transform how we care for wounds and anastomoses of patients.

Glycemic control through titration of insulin dosing remains the mainstay of diabetes mellitus treatment. Insulin therapy is generally divided into dosing with long -and short-acting insulin, where long-acting insulin provides basal coverage and short-acting insulin supports glycemic excursions associated with eating. The dosing of short-acting insulin often involves several steps for the user including blood glucose measurement and integration of potential carbohydrate loads to inform safe and appropriate dosing. The significant burden placed on the user for blood glucose measurement and effective carbohydrate counting can manifest in substantial effects on adherence. Through the application of computer vision, we have developed a smartphone-based system that is able to detect the carbohydrate load of food by simply taking a single image of the food and converting that information into a required insulin dose by incorporating a blood glucose measurement. Moreover, we report the development of comprehensive all-in-one insulin delivery systems that streamline all operations that peripheral devices require for safe insulin administration, which in turn significantly reduces the complexity and time required for titration of insulin. The development of an autonomous system that supports maximum ease and accuracy of insulin dosing will transform our ability to more effectively support patients with diabetes.