Modern nuclear medicine techniques combining anatomical and functional imaging have transformed our ability to diagnose, stage and prognosticate in paediatric oncology. Progress in the use of positron emission tomography (PET) in children with cancer has been relatively restrained compared to adults due to radiation concerns, limited research, availability, and the practical challenges associated with imaging young children. However, there have been several developments in the last decade and the role of molecular imaging in paediatric oncology will only broaden with forthcoming novel tracers and molecular radiotherapy. This review article summarises the practical aspects of nuclear imaging in paediatric oncology, discusses the main imaging methods including PET and single photon emission computed tomography (SPECT), appraises the available established and novel tracers, and summarises the evidence behind molecular imaging in paediatric lymphoma, neuroblastoma, sarcomas, thyroid cancer and other tumours. 18F-FDG PET/CT is the established method for staging and response assessment after induction chemotherapy in paediatric Hodgkin lymphoma and has high sensitivity for the detection of bone marrow disease, reducing the need for bone marrow biopsy in some cases. 123I-mIBG planar with SPECT imaging remains the mainstay for neuroblastoma imaging, however there is a well-established role for 18F-FDG PET/CT in mIBG non-avid disease, and 18F-DOPA and 68Ga-DOTA PET tracers have shown promising results as upcoming alternatives. 18F-FDG PET/CT is advocated in the staging assessment of rhabdomyosarcoma and has been shown to have excellent sensitivity in the detection of bone metastases in osteosarcoma and Ewing sarcoma, although standard chest CT is still recommended for the detection of lung metastases. The role of PET in germ cell tumours, hepatoblastoma, Wilms tumour and Langerhans cell histiocytosis is complementary to standard techniques.
Over recent years significant advances in histopathology and functional imaging techniques for the diagnosis and restaging of children with neuroblastoma have led to better quantification of disease and assessment of disease response, allowing for better treatment stratification. In this review we summarise recent changes to the International Neuroblastoma Response Criteria including the use of RECIST (Response Evaluation Criteria in Solid Tumours) guidance for measurable soft-tissue disease, replacement of technetium-99 m-methylene diphosphonate (MDP) bone scans with metaiodobenzylguanidine (MIBG) scan or [F-18]2-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/CT scanning, and a new category of minimal residual bone marrow disease.
•Poor MRI positioning makes MRI of the sacroiliac joints more difficult to interpret.•Findings related to skeletal immaturity can lead to overdiagnosis of sacroiliitis.•Optimal positioning of sacroiliac joint MRIs helps to avoid false positive diagnosis of erosions.•Knowing the appearance of haematopoetic marrow can avoid misdiagnosis of sacroiliitis on MRI.
Introduction Simulation is increasingly used throughout medicine. Within ultrasound, simulators are more established for learning transvaginal and interventional procedures. The use of modern high-fidelity transabdominal simulators is increasing, particularly in centres with large trainee numbers. There is no current literature on the value of these simulators in gaining competence in abdominal ultrasound. The aim was to investigate the impact of a new ultrasound curriculum, incorporating transabdominal simulators into the first year of training in a UK radiology academy. Methods The simulator group included 13 trainees. The preceding cohort of 15 trainees was the control group. After 10 months, a clinical assessment was performed to assess whether the new curriculum resulted in improved ultrasound skills. Questionnaires were designed to explore the acceptability of simulation training and whether it had any impact on confidence levels. Results Trainees who had received simulator-enriched training scored higher in an objective clinical ultrasound assessment, which was statistically significant (p = 0.0463). End confidence scores for obtaining diagnostic images and demonstrating pathology were also higher in the simulation group. All trainees stated that transabdominal simulator training was useful in early training. Conclusions This initial study shows that embedded into a curriculum, transabdominal ultrasound simulators are an acceptable training method that can result in improved ultrasound skills and higher confidence levels. Using simulators early in training could allow trainees to master the basics, improve their confidence, enabling them to get more educational value from clinical ultrasound experience while reducing the impact of training on service provision.
The original version of this article contained an error. Under the heading 'Limitations', the sentence 'Another limitation was the decision to exclude one reader from interobserver analysis.
AIMS: To investigate the postoperative computed tomography (CT) features resulting from the use of Nathanson retractors during laparoscopic upper gastro-intestinal surgery.MATERIALS AND METHODS: A 3-year retrospective study of 176 patients who had undergone laparoscopic upper gastro-intestinal surgery for bariatric or malignant disease was performed. Postoperative CT images [divided into early (<= 30 days) and late (>30 days)] were assessed by a consultant radiologist and liver abnormalities recorded.RESULTS: The features of a retractor injury were a hypodense lesion, abutting the liver edge, usually triangular or linear in shape. Late postoperative features included focal subcapsular retraction and associated liver atrophy. Sixty-eight percent (52/77) of patients undergoing surgery for malignancy underwent postoperative CT, compared with 11% (11/99) of those undergoing bariatric surgery. Patients with malignancy were more likely to have retraction-related liver abnormalities (14/52, 27%) at postoperative CT than those in the bariatric group (2/11, 18%).CONCLUSION: Retractor-related liver injuries at MDCT are common following laparoscopic upper gastro-intestinal surgery. Recognition of the characteristic triad of features, a hypodense lesion abutting the liver edge with a triangular or linear shape, should allow confident diagnosis. CT follow-up reveals that over time these lesions may disappear, remain unchanged, or result in a focal subcapsular scar with associated atrophy. (c) 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.