Hispanic/Latino (H/L) adults are disproportionately affected and have suboptimal control of Type 2 Diabetes (T2DM). We hypothesize that use of a Spanish-language smartphone application with structured blood glucose (BG) monitoring and proactive diabetes coaching (mySugr® PRO) will improve diabetes self-efficacy, weight, and glucose control in H/L adults with uncontrolled T2DM. Spanish-literate H/L adults with non-intensively treated T2DM and HbA1c 7.5-10.0% were enrolled. Subjects were provided with an Accu-Chek® Guide Me glucometer, trained on use of mySugr® PRO, received education on structured BG monitoring (paired testing before and 2hr post-meal), and given access to diabetes coaching. BG metrics, HbA1c, weight, waist circumference, diabetes self-efficacy and distress were measured before and after 12-weeks; acceptability & quality of the app were evaluated after 12 weeks. H/L adults (22) were enrolled, and 11 have completed to date. Subjects achieved significant reductions in HbA1c, weight, and waist circumference when compared to baseline. Diabetes self-efficacy and distress improved non-significantly. MySugr® PRO was well accepted and perceived to be useful by H/L adults with uncontrolled T2DM. Diabetes self-efficacy and distress improved, and the app provided them with motivation and intention to improve BG control. Disclosure A.A. Thorsell: None. W.C. Bevier: None. K.N. Castorino: Research Support; Abbott, Dexcom, Inc. Speaker's Bureau; Dexcom, Inc. Research Support; Lilly Diabetes, Medtronic, MannKind Corporation, Insulet Corporation. Consultant; Medscape. D. Kerr: Advisory Panel; Abbott Diagnostics. Consultant; Sanofi, Better Therapeutics, Inc. Stock/Shareholder; Glooko, Inc. B. Ulmer: Employee; Roche Diabetes Care. E. Repetto: Employee; Roche Diabetes Care. K. Gonzalez: None. L. Melero: None.

Hispanic/Latino (HL) adults bear a greater burden of type 2 diabetes (T2D), and dietary factors have been linked to almost half of cardio-metabolic disease deaths. Avocados are rich in beneficial fats, vitamins, minerals, & fiber. To test the hypothesis that avocado consumption will improve glucose control and cardio-metabolic health in HL adults with or at-risk of T2D, we recruited 59 HL adults (45 women) who were randomized to an Active (A) group - receiving free avocado vouchers for 12 weeks, or a Control (C) group - no avocado vouchers. Subjects (53 T2D, 4 at risk, 2 unknown) had clinical measurements, blood draws, and continuous glucose monitors (CGMs) at Baseline (BL) and Conclusion (CL). Daily avocado consumption logs were kept. At BL, A and C groups did not differ in avocado consumption/day (0.8±0.6 vs 0.5±0.3, respectively). At CL, A group consumption was significantly greater (1.4±0.4 vs 0.4±0.3), p<0.001. Results are shown below. No significant differences between groups were found for time in range (TIR) 70-140 or 70-180 mg/dL or time above (TAR) 180 mg/dL. Providing vouchers to HL adults with or at-risk of T2D significantly increased avocado consumption and did not affect HbA1c, fasting glucose, weight, or CGM metrics but may have influenced waist circumference (WC) and triglycerides. Disclosure W. C. Bevier: None. L. Melero: None. S. E. Sato imuro: None. A. Pai: None. M. Gordon: None. K. Gonzalez: None. N. Glantz: None. A. Sabharwal: None. D. Kerr: Consultant; Sanofi-Aventis U. S. Funding Hass Avocado Board (C2021-0068)