The authors measure the efficacy of three methods for predicting the time to infection for susceptible individuals in a population undergoing an HIV epidemic. The methods differ in whether they require detailed information of the contact network and whether they require knowledge of the initial source of infection. Efficacy is evaluated using simulations for 20 different contact patterns. Only the risk score that uses both kinds of information accounts for more than 15 per cent of individual variability. The efficacy of this score ranges from 10 per cent in very unstructured populations to 60 per cent for spatially localized contact networks. This improved performance may be explained by the larger fraction of the total variability not due to the disease dynamics. When all variables are dichotomized, the two poorer methods produce odds ratios between 1.4 and 2.3. The odds ratio for the risk score with full information ranges from 2.5 to 17. Risk assessment protocols and intervention programmes are encouraged to assess contact patterns and detect sources of infection.

Intravenous drug users are crucial to the understanding and control of human immunodeficiency virus (HIV) transmission. We have developed a population-based simulation of a community of intravenous drug users. This model was implemented using Monte Carlo techniques, which permit great flexibility in creating realistic social structures, to describe the needle-sharing network of drug users. We present the baseline behavior of this model in a generic community and demonstrate the model's utility for assessing public health interventions. Our early results demonstrate the powerful effects of social networks on HIV transmission and the importance of prevalence levels in assessing the effectiveness of interventions in the drug-injecting community.

Annals of the New York Academy of SciencesVolume 475, Issue 1 p. 359-360 Aberrant Expression of HLA-DR Determinants on Human Thyroid Cells Treated with Phytohemagglutinin and γ-Interferon and on Human Melanoma Cells Demonstration with a Binding Assay Using a New Potent 125I-Monoclonal Antibody against the HLA-DR β-Chain (MAb 03-D7) P. DE MEYTS, P. DE MEYTS Hormone and Metabolic Research UnitSearch for more papers by this authorS. HALLEZ, S. HALLEZ Hormone and Metabolic Research UnitSearch for more papers by this authorJ. L. GU, J. L. GU Hormone and Metabolic Research UnitSearch for more papers by this authorM. MERCHEZ, M. MERCHEZ Hormone and Metabolic Research UnitSearch for more papers by this authorI. ECONOMIDIS, I. ECONOMIDIS Hormone and Metabolic Research UnitSearch for more papers by this authorG. G. ROUSSEAU, G. G. ROUSSEAU Hormone and Metabolic Research UnitSearch for more papers by this authorJ. van SNICK, J. van SNICK Experimental Medicine Unit International Institute of Cellular and Molecular Pathology Avenue Hippocrate, 75 B-1200, Brussels, BelgiumSearch for more papers by this authorC. SPINEL, C. SPINEL Department of HistologySearch for more papers by this authorJ. P. SQUIFFLET, J. P. SQUIFFLET Department of Experimental SurgerySearch for more papers by this authorA. M. RAVOET, A. M. RAVOET Department of Hematology Catholic University of Louvain Medical School B-1200 Brussels, BelgiumSearch for more papers by this authorM. de BRUYERE, M. de BRUYERE Department of Hematology Catholic University of Louvain Medical School B-1200 Brussels, BelgiumSearch for more papers by this authorK. WILLARD, K. WILLARD Ludwig Cancer Institute B-1200 Brussels, BelgiumSearch for more papers by this authorF. VESSIERE, F. VESSIERE Ludwig Cancer Institute B-1200 Brussels, BelgiumSearch for more papers by this authorC. LEMOINE, C. LEMOINE Ludwig Cancer Institute B-1200 Brussels, BelgiumSearch for more papers by this authorT. BOON, T. BOON Ludwig Cancer Institute B-1200 Brussels, BelgiumSearch for more papers by this authorH. TOYODA, H. TOYODA Department of Molecular GeneticsSearch for more papers by this authorF. CHEN, F. CHEN Department of Immunology Beckman Research Institute of the City of Hope Duarte, California 91010Search for more papers by this authorJ. SHIVELY, J. SHIVELY Department of Immunology Beckman Research Institute of the City of Hope Duarte, California 91010Search for more papers by this author P. DE MEYTS, P. DE MEYTS Hormone and Metabolic Research UnitSearch for more papers by this authorS. HALLEZ, S. HALLEZ Hormone and Metabolic Research UnitSearch for more papers by this authorJ. L. GU, J. L. GU Hormone and Metabolic Research UnitSearch for more papers by this authorM. MERCHEZ, M. MERCHEZ Hormone and Metabolic Research UnitSearch for more papers by this authorI. ECONOMIDIS, I. ECONOMIDIS Hormone and Metabolic Research UnitSearch for more papers by this authorG. G. ROUSSEAU, G. G. ROUSSEAU Hormone and Metabolic Research UnitSearch for more papers by this authorJ. van SNICK, J. van SNICK Experimental Medicine Unit International Institute of Cellular and Molecular Pathology Avenue Hippocrate, 75 B-1200, Brussels, BelgiumSearch for more papers by this authorC. SPINEL, C. SPINEL Department of HistologySearch for more papers by this authorJ. P. SQUIFFLET, J. P. SQUIFFLET Department of Experimental SurgerySearch for more papers by this authorA. M. RAVOET, A. M. RAVOET Department of Hematology Catholic University of Louvain Medical School B-1200 Brussels, BelgiumSearch for more papers by this authorM. de BRUYERE, M. de BRUYERE Department of Hematology Catholic University of Louvain Medical School B-1200 Brussels, BelgiumSearch for more papers by this authorK. WILLARD, K. WILLARD Ludwig Cancer Institute B-1200 Brussels, BelgiumSearch for more papers by this authorF. VESSIERE, F. VESSIERE Ludwig Cancer Institute B-1200 Brussels, BelgiumSearch for more papers by this authorC. LEMOINE, C. LEMOINE Ludwig Cancer Institute B-1200 Brussels, BelgiumSearch for more papers by this authorT. BOON, T. BOON Ludwig Cancer Institute B-1200 Brussels, BelgiumSearch for more papers by this authorH. TOYODA, H. TOYODA Department of Molecular GeneticsSearch for more papers by this authorF. CHEN, F. CHEN Department of Immunology Beckman Research Institute of the City of Hope Duarte, California 91010Search for more papers by this authorJ. SHIVELY, J. SHIVELY Department of Immunology Beckman Research Institute of the City of Hope Duarte, California 91010Search for more papers by this author First published: July 1986 https://doi.org/10.1111/j.1749-6632.1986.tb20893.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume475, Issue1Autoimmunity: Experimental and Clinical AspectsJuly 1986Pages 359-360 RelatedInformation

Prevalence and Predictive Values Get access G. Critchfield, M.D., G. Critchfield, M.D. Division of Health Computer Sciences Department of Laboratory Medicine and Pathology University of Minnesota Search for other works by this author on: Oxford Academic Google Scholar E. Shultz, M.D., E. Shultz, M.D. Division of Health Computer Sciences Department of Laboratory Medicine and Pathology University of Minnesota Search for other works by this author on: Oxford Academic Google Scholar K. Willard, M.D. K. Willard, M.D. Division of Health Computer Sciences Department of Laboratory Medicine and Pathology University of Minnesota Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 81, Issue 3, 1 March 1984, Page 408, https://doi.org/10.1093/ajcp/81.3.408 Published: 01 March 1984

The ISO-DALT system of two-dimensional electrophoresis allows high-resolution separations of proteins and protein subunits. However, the conventional isoelectric focusing employed in this system does not give satisfactory resolution of the more basic proteins, such as histones. The BASO-DALT system was designed to obtain improved resolution of these basic proteins in the first dimension. In this system, phosphatidyl choline is used as the solubilization agent, and allows resolution of many low molecular weight basic proteins that were not seem with more conventional detergents. Using the BASO-DALT system, Novikoff hepatoma chromosomal proteins have been analyzed, and the five histones identified.