J. Bradley Aust, M.D., Ph.D. Emeritus 1960 3/17/2010 Charles T. Beer, D.Phil. Emeritus 1973 6/15/2010 Charles W. Boone, M.D., Ph.D. Emeritus 1976 5/14/2010 Michael J. Brennan, M.D. Emeritus 1958 9/22/2010 Ashley M. Brown, D.D.S. Emeritus 1974 5/27/2010 Raymond R. Brown, Ph.D. Emeritus 1956 6/23/2010 Richard A. Consigli, Ph.D. Emeritus 1976 12/10/2010 Margarida M. Dederick, M.D. Emeritus 1963 11/21/2010 Merrill J. Egorin, M.D. Active 1978 8/7/2010 Harry V. Gelboin, Ph.D. Emeritus 1963 4/13/2010 Alan M. Gewirtz, M.D. Active 1995 11/17/2010 David A. Goldthwait, M.D. Emeritus 1975 4/12/2010 Bernard Grad, Ph.D. Emeritus 1950 12/27/2010 Samuel Gross, M.D. Emeritus 1981 10/3/2010 Petre N. Grozea, M.D. Emeritus 1973 3/26/2010 Paul Hochstein, Ph.D. Emeritus 1962 6/12/2010 Karen A. Johnson, M.D., Ph.D. Active 2001 8/16/2010 Fred F. Kadlubar, Ph.D. Active 1978 12/4/2010 Karl Karrer, M.D. Emeritus 1967 8/27/2010 Paul S. Lavik, Ph.D. Emeritus 1958 10/20/2010 Elizabeth H. Leduc, Ph.D. Emeritus 1959 1/30/2010 Leon L. Miller, Ph.D. Emeritus 1958 9/3/2010 Gerald C. Mueller, M.D., Ph.D. Emeritus 1948 11/7/2010 Gregory R. Mundy, M.D. Active 2002 2/25/2010 Leo Orris, M.D. Emeritus 1963 6/16/2010 William W. Payne, Sc.D. Emeritus 1962 12/20/2010 Aaron R. Rausen, M.D. Emeritus 1975 7/7/2010 Allen F. Reid, M.D., Ph.D. Emeritus 1951 7/30/2010 Benjamin A. Rubin, Ph.D. Emeritus 1956 3/8/2010 Robert J. Rutman, Ph.D Emeritus 1962 9/20/2010 Jessie A. Satia, Ph.D. Active 1999 2/4/2010 Kathy Schiffman, B.A. Affiliate 2002 5/15/2010 Jennie B. Shatton, M.S. Emeritus 1969 9/21/2010 Hisashi Shinozuka, M.D., Ph.D. Emeritus 1972 9/20/2010 Ian C. Summerhayes, Ph.D. Active 1991 7/20/2010 Richard D. Williams, M.D. Active 1981 5/28/2010
A review of 128 cases of "primary" ovarian müllerian carcinoma treated at the King George V Memorial Hospital was undertaken to determine the relative frequency with which such tumors were associated with evidence of multifocal primary neoplasia. Of the 128 cases studied, 115 were invasive carcinomas and 13 were noninvasive or borderline ovarian tumors ("tumors of low malignant potential"). Eight of 10 borderline serous ovarian tumors (80%) and 37 of 75 invasive serous carcinomas (49%) exhibited evidence of independent primary neoplasia at more than one anatomical site in the biopsy material available for review. Many of these cases represented bilateral primary ovarian tumors, but autochthonous extraovarian neoplasia was also commonly encountered. A single borderline endometrioid ovarian tumor and six of 15 endometrioid carcinomas (40%) were associated with biopsy-proven multifocal primary tumorigenesis. These were predominantly neoplasms in one or both ovaries plus adenocarcinoma in the uterine corpus. Other histological types of malignant common epithelial tumors of the ovaries did not demonstrate any such tendency, highlighting major differences in pathogenesis between members of this loosely associated group of ovarian cancers. Our study suggests that gynecological endometrioid and serous malignancies are commonly multifocal and we feel this has significant implications for the way these neoplasms are staged and therefore treated.
CancerVolume 4, Issue 6 p. 1210-1223 ArticleFree Access A study of the incidence and histogenesis of endocervical metaplasia and intraepithelial carcinoma. Observations on 400 uteri removed for noncervical disease Lee Howard Jr. M.D., Lee Howard Jr. M.D. Department of Pathology, Duke University School of Medicine, Durham, North CarolinaSearch for more papers by this authorCyrus C. Erickson M.D., Cyrus C. Erickson M.D. Department of Pathology, Duke University School of Medicine, Durham, North CarolinaSearch for more papers by this authorLeland D. Stoddard M.D., Leland D. Stoddard M.D. Department of Pathology, Duke University School of Medicine, Durham, North CarolinaSearch for more papers by this author Lee Howard Jr. M.D., Lee Howard Jr. M.D. Department of Pathology, Duke University School of Medicine, Durham, North CarolinaSearch for more papers by this authorCyrus C. Erickson M.D., Cyrus C. Erickson M.D. Department of Pathology, Duke University School of Medicine, Durham, North CarolinaSearch for more papers by this authorLeland D. Stoddard M.D., Leland D. Stoddard M.D. Department of Pathology, Duke University School of Medicine, Durham, North CarolinaSearch for more papers by this author First published: November 1951 https://doi.org/10.1002/1097-0142(195111)4:6<1210::AID-CNCR2820040607>3.0.CO;2-9Citations: 68AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume4, Issue6November 1951Pages 1210-1223 ReferencesRelatedInformation