Thirteen rhesus monkeys were trained to perform delayed alternation and visual discrimination tasks and intraventricular cannulas were implanted. The animals were divided in three groups: injected with anti-caudate nucleus; antihippocampal; and normal gamma globulin, respectively. They were then tested for retention. The anti-caudate and anti-hippocampal groups were significantly impaired in the delayed alternation performance as compared to the nromal gamma globulin group. The impairment was temporary. No group was impaired on visual discrimination presented along the delayed alternation task.

IN a vast literature on learning and retention there are, surprisingly, no data concerning effects of experimentally controlled hibernation. In contrast, experiments to investigate the effects of hypothermia are increasing. Andjus et al.1 have shown that retention is unimpaired after hypothermia even in animals cooled to near 0° C. On the other hand, initial learning, investigated after recovery from hypothermia, has been most frequently found to be significantly impaired in subjects whose body temperature has been lowered to 0°–5° C, but unaffected in subjects cooled to 13°–32° C1. In general, the longer the time between recovering from hypothermia and the beginning of learning, the smaller was the impairment observed (paper presented by N. Mrosovsky to the third International Symposium on Natural Mammalian Hibernation in Toronto in 1965).

Chez le spermophile, la teneur en glutamine et en acide glutamique cérébral au cours du réveil du sommeil hivernal était inchangée. Pendant le réchauffement des animaux refroidis, la glutamine et GABA étaient remarquablement élevés.

On étudie ici la teneur en glutamine, en acide glutamique et en GABA dans des différentes parties du cerveau chez le Spermophile en sommeil hivernal profond et après le réveil de l'hibernation. Les changements les plus remarquables de l'acide glutamique et du GABA ont été constatés dans les structures sous-corticales regardées comme essentielles pour la régulation de ces processus physiologiques coordonnés.

La teneur en glutamine dans le cerveau des chatons nouveau-nés au cours de la maturation cérébrale est comparable à celle des animaux adultes. Les concentrations en acide glutamique et en GABA augmentent et vers la fin du premier mois postnatal correspondent au niveau des adultes.

IN an attempt to investigate the possible differential reactivity of various cerebral structures when exposed to the action of different brain region anti-sera, it has been shown that the injection of heterologous anti-caudate nucleus antibody into the lateral cerebral ventricle of the cat was followed by pronounced electrographic abnormalities, confined mainly to the caudate nucleus. Since the electrical activity of other, simultaneously investigated brain regions was not essentially modified, the alterations observed were interpreted as being strongly suggestive of the possibility that the anti-caudate antibody has an affinity for the homologous nervous tissue1.

Journal Article EFFECTS OF STIMULATION OF FRONTAL CORTEX AND HIPPOCAMPUS ON BEHAVIOUR IN THE MONKEY Get access L. WEISKRANTZ, L. WEISKRANTZ Search for other works by this author on: Oxford Academic PubMed Google Scholar LJ. MIHAILOVIC, LJ. MIHAILOVIC 1On leave from Medical School, Univ. of BelgradeBelgrade, Yugoslavia Search for other works by this author on: Oxford Academic PubMed Google Scholar C. G. GROSS C. G. GROSS 2A U.S. Public Health research fellow Search for other works by this author on: Oxford Academic PubMed Google Scholar Brain, Volume 85, Issue 3, September 1962, Pages 487–504, https://doi.org/10.1093/brain/85.3.487 Published: 01 September 1962

IT is well known that anti-tissue antibodies, when injected into an animal of the donor species, may exhibit the selective affinity for the homologous organ and produce certain modifications in its morphological and functional state1. The damaging effects of anti-tissue antibodies have been demonstrated in different organs2. However, no information could be found in the literature available concerning the physiopathological events associated with an in vivo collision between anti-brain antibodies and the corresponding nervous tissue. Bearing in mind the high complexity of morphological and functional organization of the brain, a series of immuno-electro-physiological experiments has been undertaken to investigate the possible differential reactivity of various cerebral structures when exposed to the action of different brain region anti-sera. The present communication, as a part of these investigations, is a preliminary report concerning only some of the effects of intraventricularly administered anti-n. caudatus antibody on the electrical activity of various parts of the cat brain.

Unilateral or bilateral stimulation of the region surrounding the sulcus principalis of the cortex of the monkey interferes with delayed alternation performance. It is without effect on auditory discrimination performance. Bilateral stimulation is more disrupting than unilateral stimulation. The impairment is limited in time to the period of stimulation and is fully reversible.