ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTToward the total synthesis of quassinLeon Mandell, D. E. Lee, and L. F. CourtneyCite this: J. Org. Chem. 1982, 47, 4, 610–615Publication Date (Print):February 1, 1982Publication History Published online1 May 2002Published inissue 1 February 1982https://pubs.acs.org/doi/10.1021/jo00343a003https://doi.org/10.1021/jo00343a003research-articleACS PublicationsRequest reuse permissionsArticle Views276Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Nine novel analogues of 5,5-diphenylhydantoin bearing a CF3 group(s) in the meta or para position of one or both rings were synthesized. Preliminary evaluation of all the analogues (performed by the ADD Program, NIH) indicated no significant anticonvulsant activity against electrical or chemical shock in mice at doses of less than or equal to 100 mg/kg. The analogue 5,5-bis[4-(trifluoromethyl)phenyl]hydantoin (1) was synthesized labeled with 14C in the 4 position of the hydantoin ring. Certain physicochemical properties (pKa, partition ratio, protein binding, etc.) and the LD50 of 1 in mice (40 mg/kg, ip; 100 mg/kg, po) were determined. The disposition of [14C]1 was determined in rodents. The compound was excreted unchanged in rat feces (94% in 18 days), urinary excretion less than 0.5%. The half-life of elimination of [14C]1 from plasma was 67-72 h (ip and iv) in rats and 115 h (ip) in mice. Studies of tissue distribution and biliary excretion of [14C]1 indicate low tissue/plasma ratios (due to high plasma binding, 97%) and low biliary excretion. The lack of metabolism of [14C]1 may possibly be explained by (1) the strong electron-withdrawing effects of CF3 substituents, (2) the preemption of the primary metabolic sites, (3) the accompanying steric hindrance, and (4) the apparent inability of the CF3 group to undergo the NIH shift.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTControlled-potential reduction of cyclopropyl ketonesLeon Mandell, Judy C. Johnston, and R. A. Day Jr.Cite this: J. Org. Chem. 1978, 43, 8, 1616–1618Publication Date (Print):April 1, 1978Publication History Published online1 May 2002Published inissue 1 April 1978https://doi.org/10.1021/jo00402a041RIGHTS & PERMISSIONSArticle Views111Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (319 KB) Get e-Alerts Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA one-step conversion of RCH2CO2H to RCH:OLeon Mandell, Richard F. Daley, and R. A. Day Jr.Cite this: J. Org. Chem. 1977, 42, 8, 1461–1462Publication Date (Print):April 1, 1977Publication History Published online1 May 2002Published inissue 1 April 1977https://pubs.acs.org/doi/10.1021/jo00428a043https://doi.org/10.1021/jo00428a043research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemical reduction of geranial, farnesal, and crotonaldehydeJudy C. Johnston, James D. Faulkner, Leon Mandell, and R. A. Day Jr.Cite this: J. Org. Chem. 1976, 41, 15, 2611–2614Publication Date (Print):July 1, 1976Publication History Published online1 May 2002Published inissue 1 July 1976https://pubs.acs.org/doi/10.1021/jo00877a021https://doi.org/10.1021/jo00877a021research-articleACS PublicationsRequest reuse permissionsArticle Views214Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic organic electrochemistry. Application to perhydrophenanthrene synthesesLeon Mandell, Richard F. Daley, and R. A. Day Jr.Cite this: J. Org. Chem. 1976, 41, 26, 4087–4089Publication Date (Print):December 1, 1976Publication History Published online1 May 2002Published inissue 1 December 1976https://pubs.acs.org/doi/10.1021/jo00888a008https://doi.org/10.1021/jo00888a008research-articleACS PublicationsRequest reuse permissionsArticle Views306Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Abstract3‐Methyl‐crotonsäure (I) kann durch das Hydrid (II) zum Carbinol (III) reduziert und dann durch aktivierten Braunstein zum Aldehyd (IV) oxidiert werden.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWagner-Meerwein rearrangements. IV. Some reassignments of structureHershel L. Herzog, Olga Gnoj, Leon Mandell, Giangiacomo Nathansohn, and Aristide VigevaniCite this: J. Org. Chem. 1967, 32, 9, 2906–2910Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/jo01284a063https://doi.org/10.1021/jo01284a063research-articleACS PublicationsRequest reuse permissionsArticle Views112Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13-hydrogen satellite nuclear magnetic resonance spectrum of nonequivalent protons in acetalLana S. Rattet, Leon. Mandell, and Jacob H. GoldsteinCite this: J. Am. Chem. Soc. 1967, 89, 10, 2253–2255Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/ja00986a003https://doi.org/10.1021/ja00986a003research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reaction of Δ2-Cyclohexenone with β-Methylallylmagnesium Chloride and Isobutylmagnesium Chloride. The Effect of Added Cuprous Chloride1Leon Mandell and John M. BrodmannCite this: J. Org. Chem. 1966, 31, 2, 591–593Publication Date (Print):February 1, 1966Publication History Published online1 May 2002Published inissue 1 February 1966https://pubs.acs.org/doi/10.1021/jo01340a506https://doi.org/10.1021/jo01340a506research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Total Syntheses of d,l-Matrine and d,l-Leontine1Leon Mandell, K. P. Singh, J. T. Gresham, and W. J. FreemanCite this: J. Am. Chem. Soc. 1965, 87, 22, 5234–5236Publication Date (Print):November 1, 1965Publication History Published online1 May 2002Published inissue 1 November 1965https://doi.org/10.1021/ja00950a043Request reuse permissionsArticle Views539Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (351 KB) Get e-Alertsclose Get e-Alerts