Novelty and appropriateness are two fundamental components of creativity. However, the way in which novelty and appropriateness are separated at behavioral and neural levels remains poorly understood. In the present study, we aim to distinguish behavioral and neural bases of novelty and appropriateness of creative idea generation. In alignment with two established theories of creative thinking, which respectively, emphasize semantic association and executive control, behavioral results indicate that novelty relies more on associative abilities, while appropriateness relies more on executive functions. Next, employing a connectome predictive modeling (CPM) approach in resting-state fMRI data, we define two functional network-based models—dominated by interactions within the default network and by interactions within the limbic network—that respectively, predict novelty and appropriateness (i.e., cross-brain prediction). Furthermore, the generalizability and specificity of the two functional connectivity patterns are verified in additional resting-state fMRI and task fMRI. Finally, the two functional connectivity patterns, respectively mediate the relationship between semantic association/executive control and novelty/appropriateness. These findings provide global and predictive distinctions between novelty and appropriateness in creative idea generation.

Creativity is critical to economic growth and societal progress. However, assessing creativity using objective approaches remains a challenge. To address this, we employ three objective indicators based on semantic distance to quantify the originality and appropriateness of creativity by analyzing long texts in a story-writing experiment. Global and local distances were generated separately by computing the mean distance of the whole text and the distance between adjacent sentences, and they were positively correlated with story originality in writing. Global cohesion was positively correlated with story rationality in writing, as generated by computing the semantic coherence between the text and story context. At the behavioral level, three semantic indicators were used to measure originality and appropriateness of creativity and reflected individual differences, including creative achievement and creative personality. At the neural level, global distance was best predicted by the features of the salience and default networks, whereas global cohesion corresponded to the control and salience networks. These findings point to a stable neural basis for semantic indicators and verify the idea of separating different dimensions of creativity. Taken together, our results demonstrate the significance of semantic indicators in assessing creativity and provide insights into analyzing long texts in natural paradigm.

Creativity, the ability to generate original and valuable products, has long been linked to semantic retrieval processes. The associative theory of creativity posits flexible retrieval ability as an important basis for creative idea generation. However, there is insufficient research on how flexible memory retrieval acts on creative activities. This study aimed to capture different dynamic aspects of retrieval processes and examine the behavioral and neural associations between retrieval flexibility and creativity. We developed 5 metrics to quantify retrieval flexibility based on previous studies, which confirmed the important role of creativity. Our findings showed that retrieval flexibility was positively correlated with multiple creativity-related behavior constructs and can promote distinct search patterns in different creative groups. Moreover, high flexibility was associated with the lifetime of a specific brain state during rest, characterized by interactions among large-scale cognitive brain systems. The flexible functional connectivity within and between default mode, executive control, and salience provides further evidence on brain dynamics of creativity. Retrieval flexibility mediated the links between the lifetime of the related brain state and creativity. This new approach is expected to enhance our knowledge of the role of retrieval flexibility in creativity from a dynamic perspective.

BACKGROUND:Major depressive disorder (MDD) is a highly heterogeneous disease, which brings great difficulties to clinical diagnosis and therapy. Its mechanism is still unknown. Prior neuroimaging studies mainly focused on mean differences between patients and healthy controls (HC), largely ignoring individual differences between patients.METHODS:This study included 112 MDD patients and 93 HC subjects. Resting-state functional MRI data were obtained to examine the patterns of individual variability of brain functional connectivity (IVFC). The genetic risk of pathways including dopamine, 5-hydroxytryptamine (5-HT), norepinephrine (NE), hypothalamic-pituitary-adrenal (HPA) axis, and synaptic plasticity was assessed by multilocus genetic profile scores (MGPS), respectively.RESULTS:The IVFC pattern of the MDD group was similar but higher than that in HCs. The inter-network functional connectivity in the default mode network contributed to altered IVFC in MDD. 5-HT, NE, and HPA pathway genes affected IVFC in MDD patients. The age of onset, duration, severity, and treatment response, were correlated with IVFC. IVFC in the left ventromedial prefrontal cortex had a mediating effect between MGPS of the 5-HT pathway and baseline depression severity.LIMITATIONS:Environmental factors and differences in locations of functional areas across individuals were not taken into account.CONCLUSIONS:This study found MDD patients had significantly different inter-individual functional connectivity variations than healthy people, and genetic risk might affect clinical manifestations through brain function heterogeneity.

OBJECTIVE:We have recently reported significantly higher DNA methylation in brain-derived neurotrophic factor (BDNF) exon VI in major depressive disorder (MDD). This study aimed to investigated cortical changes and their associations with DNA methylations in BDNF exon VI in MDD. METHODS:Data of 93 patients with MDD and 59 controls were involved in statistics. General linear regressions (GLM) were performed to analyze thickness and gyrification changes in MDD and their association with DNA methylation in BDNF exon VI in patients with MDD and controls. RESULTS:Significantly decreased cortical thickness (CT) in left lateral orbitofrontal cortex (LOFC), left superior temporal lobe (ST) and right frontal pole (FP) and decreased local gyrification index (lGI) in left superior parietal lobe (SP) were found in MDD. The associations between DNA methylation in 3 CpG sites in BDNF exon VI and lGI in left SP were significantly different in patients and controls. DNA methylations in BDNF132 (β = -0.359, P < 0.001), BDNF137 (β = -0.214, P = 0.032), and BDNF151 (β = -0.223, P = 0.025) were significantly negatively associated with lGI in left SP in MDD. CONCLUSION:The negative association between BDNF exon VI methylation and lGI in left SP might imply a potential epigenetic marker associated with cortical gyrification reduction in patients with MDD.

Anodal transcranial direct current stimulation (tDCS) over the left dorsal lateral prefrontal cortex (lDLPFC) can improve distraction suppression ability, possibly by distantly regulating the connection properties of several large-scale brain networks and local brain state changes. However, little is known about the local state alteration that tDCS can induce in distant but task-related regions and the relationship between performance enhancement and local state alteration in potentially related regions, resulting in inefficient and uncertain tDCS regulation. We aimed to examine the alteration of brain local state before and after tDCS and its relationship with performance enhancement. With the within-subject design, the participants received anodal (1.5 mA) and sham tDCS at F3 (lDLPFC) for 20 min. The visual search task and resting-state functional magnetic resonance imaging (rsfMRI) were performed before and after stimulation. Anodal tDCS significantly enhanced distraction suppression. The amplitude of low-frequency fluctuation (ALFF) in the left parietal region significantly decreased, the decrement significantly positively correlated with performance enhancement after anodal tDCS. As well, the regional homogeneity (ReHo) in the left precuneus significantly increased, and the increasement significantly positively correlated with performance enhancement. Anodal tDCS over the lDLPFC can distantly modulate the local state of the brain and improve the distraction suppression ability. These two aspects are closely related and provide a direct and efficient approach to enhancing performance.

Gender differences in creativity partly underscore the diversity between males and females in society. Divergent thinking forms the core of creativity and enables humans to innovate and solve problems. Sex differences in functional activation associated with divergent thinking may reflect the use of distinct strategies in males and females when faced with tasks involving creativity. Although female-specific white matter associated to creativity has been found, fractional anisotropy measuring structural connectivity which can better reflect the degree of brain regions interplay should be adapted to corroborate sex-specific WM connectivity related to divergent thinking. Using fractional anisotropy indexes derived from diffusion tensor imaging in 425 participants (118 males), we observed that divergent thinking was positively associated with fractional anisotropy in the corpus callosum and right superior longitudinal fasciculus in females and was positively associated with fractional anisotropy in the right tapetum in males. Our findings provide insight into sex-specific intra- and inter-hemispheric structural connectivity bases underlying divergent thinking.