BACKGROUND:Diarrheal irritable bowel syndrome (IBS-D) is a functional gastrointestinal disorder characterized by abdominal pain accompanied by recurrent diarrhea that significantly impacts the quality of life and mental health of patients. AIM:To investigate the clinical efficacy of Xifeng Huashi and its effects on the mental status of patients diagnosed with IBS-D. METHODS:Data from 128 patients with IBS-D treated at the Nanjing University of Chinese Medicine Affiliated Hospital of Integrated Traditional Chinese and Western Medicine between June 2023 and May 2024 were divided into control and research groups, with 64 patients in each group. The control group received conventional treatment with Western medicine alone, whereas the research group was prescribed Xifeng Huashi. Differences in specific indices between the two groups were observed and compared using relevant assessment tools. RESULTS:The research group showed a higher total effective rate (92.19% vs 76.56%; P = 0.027) and lower traditional Chinese medicine symptom score (5.07 ± 3.11 vs 7.38 ± 3.68; P < 0.001) than the control group. Post-treatment, the research group exhibited significantly lower levels of pro-inflammatory cytokines (tumor necrosis factor-α: 18.80 ± 4.02 ng/L vs 21.09 ± 4.10 ng/L, P = 0.002; interleukin-6:14.84 ± 4.06 ng/L vs 19.80 ± 4.42 ng/L, P < 0.001) and higher levels of the anti-inflammatory cytokine interleukin-10 (48.53 ± 5.02 ng/L vs 46.06 ± 4.94 ng/L, P = 0.006). Moreover, markers of intestinal mucosal barrier function (diamine oxidase: 6.53 ± 2.35 ng/mL vs 7.66 ± 2.40 ng/mL, P = 0.008; D-lactate: 0.18 ± 0.04 mmol/L vs 0.20 ± 0.06 mmol/L, P = 0.004; lipopolysaccharides: 44.77 ± 8.16 pg/mL vs 48.20 ± 8.15 pg/mL, P = 0.019) were significantly improved in the research group. In addition, Self-rating Anxiety Scale (37.33 ± 5.73 vs 39.59 ± 6.36; P = 0.036) and Self-rating Depression Scale scores (34.77 ± 6.71 vs 38.06 ± 6.52; P = 0.006) were lower in the research group. The recurrence rate was significantly lower in the research group than in the control group (18.64% vs 40.82%, P = 0.001). CONCLUSION:Xifeng Huashi is effective for the treatment of IBS-D and manifests advantages in improving clinical symptoms and mental status, as well as reducing the short-term relapse rate.

Background and Aim Xifenghuashi formula (XFHS),a traditional Chinese medicine,shows promising effects in treating diarrhea-predominant irritable bowel syndrome (IBS-D),but its mechanisms are unclear.This study aims to confirm XFHS's efficacy in IBS-D treatment and its influence on the gut microbiota-bile acid-farnesoid X receptor (FXR)-fibroblast growth factor19/15 (FGF19/15) axis. Experimental procedure A randomized,double-blind,placebo-controlled clinical trial was conducted to assess XFHS's effectiveness.In animal experiments,IBS-D rat models were induced by oral gavage of senna along with restraint stress and divided into six groups:the IBS-D group,XFHS group (administered XFHS),ANTIBIOTIC group (administered antibiotic-s),A+XFHS group (administered antibiotics and XFHS),FGF401 (a FGFR4 receptor inhibitor) group (administered FGF401),and F+XFHS group (administered FGF401 and XFHS).Human and rat fecal samples,along with rat liver and terminal ileum samples,were analyzed for bile acid concentration,16S rRNA sequencing,and western blotting. Results and Conclusion XFHS could enhance the abundance of bile salt hydrolase (BSH)-active bacteria and decrease the abundance of short-chain fatty acids (SCFAs)-producing bacteria in the IBS-D patients to a certain extent,and the same trend was found in the IBS-D rats.XFHS reduced the concentration of total fecal bile acids (including primary,conjugated,and unconjugated bile acids) in IBS-D patients and rats.However,this effect was eliminated by fibroblast growth factor receptor 4 (FGFR4) blockade in IBS-D rats.Furthermore,XFHS increased the protein expression of FXR and FGF15 in the terminal ileum,FGFR4 in the liver,and decreased the expression of cytochrome P450 7A1 (CYP7A1) in the liver.Overall,XFHS alleviated symptoms of IBS-D and restored the homeostasis of the gut microbiota and bile acid metabolism by regulating the gut microbiota-bile acid-FXR-FGF15-FGFR4 axis. Trial registration number (if clinical trial) ITMCTR,ITMCTR2100004795

Colorectal Cancer (CRC) is a prevalent global malignant tumor, and conventional therapies and drugs for CRC are limited by poor targeting and severe toxic side effects. Existing reviews on hydrogel-based CRC treatments mainly focus on synthetic materials or single-responsive systems concerning drug loading and local delivery. Natural polysaccharides possess inherent anti-inflammatory, antioxidant and antitumor activities, and polysaccharide hydrogels (PSHs) prepared from them exhibit favorable biocompatibility, tunable structures and potential targeting capability, which can synergistically enhance the efficacy of loaded drugs and thus become a research hotspot. This article summarizes the pathogenesis and conventional treatments of CRC, introduces monocomponent and composite PSHs as well as physical and chemical crosslinking methods, and emphasizes their tumor microenvironment (TME)-responsive mechanisms, combined drug effects and clinical applications. It also analyzes the challenges in safety evaluation and practical application, and summarizes recent advances in the use of artificial intelligence (AI) for PSHs design, regulation, performance prediction and implementation. This paper serves as a reference for follow-up research and clinical translation of hydrogels prepared from natural polysaccharides for the treatment of CRC.

Background Serum high-density lipoprotein cholesterol (HDL-c) may influence cancer development. However, its relationship with the histological grade of pancreatic ductal adenocarcinoma (PDAC) is not well understood. This study aims to explore the potential associations between serum HDL-c levels and different histological grades of PDAC. Methods This retrospective study included 181 patients with pathologically confirmed PDAC who underwent radical surgery. Clinical data, blood biochemical results, imaging features, and pathological details of the patients were collected, such as age, gender, diabetes, hypertension, tumor grade, tumor size and location, high-density lipoprotein (HDL-c), low-density lipoprotein (LDL), total cholesterol (TC), triglycerides (TG), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA). Results Patients with high-grade PDAC had significantly lower HDL-c levels compared to those with low-grade PDAC across both training and validation cohorts ( P < 0.05). Significant associations were found between HDL-c levels and high-grade PDAC in the training ( P < 0.001) and validation ( P = 0.044) groups. Moreover, HDL-c levels were inversely related to lymph node metastasis in the training ( P = 0.001) and validation ( P = 0.012) sets. Conclusions Lower HDL-c levels are associated with high-grade PDAC and lymph node metastasis, suggesting that HDL-c may play a protective role in the progression of PDAC.

ObjectiveTo investigate the protective effects of Quercetin, an antioxidant and anti-apoptotic flavonoid, against rifampicin (RFP)-induced hepatocyte injury via the Hippo-YAP signaling pathway.MethodsA rifampicin-induced hepatocyte injury model was established using HepaRG cells. HepaRG cells were divided into Control, RFP Model, Quercetin (15 μM), and Verteporfin (YAP inhibitor) groups. Cell viability was assessed by the CCK-8 assay, apoptosis by Annexin V/PI staining, and mitochondrial membrane potential (MMP) by TMRE staining. YAP localization was evaluated by immunofluorescence, and the expression of Hippo–YAP and apoptosis-related genes was analyzed by Western blot and qRT-PCR.ResultsQuercetin significantly improved cell viability, reduced apoptosis, and restored MMP in RFP-injured HepaRG cells. RFP activated the Hippo pathway by upregulating MST1 and LATS1, increasing YAP phosphorylation, and promoting apoptosis-related protein expression (Caspase-3, BAX), while downregulating anti-apoptotic BCL-2. Quercetin reversed these effects by inhibiting MST1/LATS1 activation, reducing YAP phosphorylation, and promoting its nuclear translocation. The protective effects were partially attenuated by Verteporfin, indicating Hippo–YAP pathway involvement.ConclusionQuercetin alleviates RFP-induced hepatocyte injury by suppressing Hippo pathway kinases MST1 and LATS1, reducing YAP phosphorylation, and enhancing YAP nuclear translocation, thereby improving MMP and inhibiting apoptosis.

Background:Predicting endoscopic remission is crucial for optimizing clinical treatment strategies and switching biologics in Crohn's disease (CD). Mucosal healing (MH) is a key therapeutic target. This study aimed to develop a clinically applicable prediction model for early MH in CD patients receiving biological therapy. Methods:This study retrospectively analyzed 120 CD patients diagnosed between 2018 and 2023, randomly divided into a training cohort and an internal validation cohort 1. Additionally, 34 prospectively enrolled CD patients diagnosed between 2024 and 2025 formed an internal validation cohort 2. Clinical indicators and conventional imaging features were evaluated to establish a clinical model. Radiomics features were extracted from computed tomography enterography (CTE) images, with regions of interest (ROIs) manually delineated to align with ulcerated intestinal segments identified through colonoscopy. A radiomics model was constructed, and a radiomics score (Rad-score) was derived. A clinical-radiomics nomogram was then developed by integrating Rad-score with clinical risk factors. Model performance was assessed using discrimination, calibration, decision curve analysis (DCA), and clinical impact curves. Results:The clinical-radiomics nomogram demonstrated strong predictive performance, with AUC values of 0.948 (95% CI: 0.902-0.995) in the training cohort, 0.925 (95% CI: 0.805-1.0) in the internal validation cohort 1, and 0.940 (95% CI: 0.802-0.993) in the internal validation cohort 2. The nomogram outperformed standalone clinical and radiomics models, with DCA confirming its clinical utility. Conclusion:The developed nomogram effectively predicts early MH in CD patients undergoing biological therapy, providing a practical tool for clinicians to optimize treatment strategies and improve outcomes.

The aim of this study was to explore the effects of Huangqin Tang(HQT) on the NLRP3/Caspase-1 signaling pathway in mice with DSS-induced ulcerative colitis(UC). C57BL/6J mice were randomly divided into a blank group, a model group(DSS group), and low-, medium-and high-dose HQT groups(HQT-L, HQT-M, and HQT-H), and western medicine mesalazine group(western medicine group). The UC model was induced in mice. Subsequently, the mice in the HQT-L, HQT-M, HQT-H groups, and the western medicine group were given low-, medium-, high-dose HQT, and mesalazine suspension by gavage, respectively, while those in the blank and DSS groups were given an equal volume of distilled water by gavage. After 10 days of administration, the body weight, DAI scores, and colonic histopathological score of mice in each group were determined. The levels of IL-6, IL-10, IL-1β, and TNF-α in serum were determined by ELISA. The mRNA expression of NLRP3 and Caspase-1 in colon tissues was determined by RT-qPCR. The protein expression of NLRP3 and Caspase-1 in colon tissues was detected by immunohistochemistry. The results showed that compared with the blank group, the DSS group showed decreased body weight of mice and increased DAI scores and intestinal histopathological score. Compared with the DSS group, the HQT groups and the western medicine group showed improved DAI scores, especially in the HQT-M, HQT-H, and the western medicine groups(P<0.05). The intestinal histopathological scores of the HQT groups and the western medicine group significantly decreased, especially in the HQT-M, HQT-H, and the western medicine groups(P<0.05). In addition, compared with the blank group, the DSS group showed elevated expression of NLRP3 and Caspase-1 in colon tissues, increased serum levels of IL-6, IL-1β, and TNF-α, and decreased IL-10 level. Compared with the DSS group, the HQT groups and the western medicine group displayed decreased expression of NLRP3 and Caspase-1 in colon tissues, reduced serum levels of IL-6, IL-1β, and TNF-α, and increased IL-10 level. The improvement was the most significant in the HQT-H group and the western medicine group(P<0.01). In conclusion, HQT may reduce the expression of NLRP3 and Caspase-1 in colon tissues, reduce the se-rum levels of IL-6, IL-1β, and TNF-α, and increase the expression of IL-10 by regulating the classic pyroptosis pathway of NLRP3/Caspase-1, thereby improving the symptoms of intestinal injury and inflammatory infiltration of intestinal mucosa in DSS mice to achieve its therapeutic effect.

胃食管反流病是消化科的常见病、多发病,属于中医"吐酸""嘈杂""呕苦""食管瘅"等范畴.田耀洲教授认为胃食管反流病的基本病机为内邪阻滞、胃失和降、浊气上逆;病因为饮食不节、情志不遂及素体脾胃虚弱,病位在食管,与肝、脾胃等脏腑功能失调密切相关;内生之湿、热、痰、气滞、血瘀既是病理产物,更是致病因素,贯穿于发病的始终,而湿热痰在本病演变的进展中尤为关键.临证以清化内邪、通降胃气为治疗大法,兼疏肝理气、扶正祛邪,临床疗效可靠.

目的 探究在长期临床等效剂量下4种清热燥湿类中药对正常小鼠肠道菌群、胆汁酸及短链脂肪酸的影响.方法 30只Balb/c雄性小鼠被随机分为对照组、苦参组、黄连组、黄柏组和黄芩组,每组各6只.除对照组外,苦参组、黄柏组、黄连组和黄芩组给药剂量分别为2.34、3.12、1.3 g·kg-1和2.6 g·kg-1,连续灌胃2周,采用液相色谱-串联质谱法检测粪便中短链脂肪酸和胆汁酸含量,利用16S rRNA高通量基因测序技术分析肠道内容物中菌群结构变化.结果 清热燥湿类中药对正常小鼠粪便中6种短链脂肪酸无明显影响.在常见的23种胆汁酸中,与正常组相比,黄芩组、苦参组、黄连组和黄柏组分别有4、3、2、1种胆汁酸显著变化.从肠道菌群丰度变化上看,与对照组相比,除苦参组外,黄连组、黄芩组和黄柏组小鼠厚壁菌门均呈现下降趋势,拟杆菌门均呈现上升趋势,其中黄连组变化更显著.结论 苦参、黄柏、黄连和黄芩对正常小鼠长期药效剂量下短链脂肪酸影响较小,但可以通过改变肠道菌群结构影响胆汁酸含量的变化.

肠易激综合征( irritable bowel syndrome,IBS)是一种慢性功能性胃肠疾病,以反复腹痛为主要特征,伴随粪便性状或排便频率的异常[1].在罗马Ⅳ诊断标准的基础上,根据患者粪便性状(硬状或块状样便与松散或水样便的比例) , IBS 被分为腹泻型(IBS with diarrhea,IBS-D)、便秘型(IBS with con-stipation,IBS-C)、混合型( IBS with mixed symptoms of constipation and diarrhea,IBS-M)及不确定型( un-subtyped IBS,IBS-U) [2].目前,IBS在全球发病率约为10％ ～20％ [3] ,我国为1. 4％ ～11. 5％ [4] ,女性患病率普遍高于男性[5].腹泻型在我国较为常见[6] ,约占40％ [1] ,呈逐年升高的趋势.本病病程缠绵难愈,除腹痛、腹部不适、腹胀和排便习惯紊乱等胃肠道症状,还包括疲劳、纤维肌痛、社交功能差和情绪幸福感下降等肠外症状,严重影响个人生活质量和工作效率、卫生保健服务及社会经济成本.本病病因及发病机制尚未完全明确,越来越多的证据表明肠道微生物在IBS-D病理生理过程中起着重要作用[7-8].目前现代医学主要是通过补充微生态制剂、使用抗生素、粪菌移植、饮食干预来调节肠道菌群;祖国医学则包括口服中药、针灸及穴位贴敷等外治法.现就传统及现代医学在IBS-D肠道菌群失调治疗进展方面进行归纳总结,为今后治疗IBS-D肠道菌群紊乱提供参考.

功能性便秘(FC)是消化科常见病、多发病之一,以大便次数减少、粪质干结、排便不尽感为主要临床表现.现代医学对其尚缺乏特异性的治疗方法和药物,中医药的治疗优势逐渐显现.功能性便秘发病机制复杂,其发病与肠-脑相互作用障碍等有关.田耀洲教授从事中医治疗消化道疾病研究多年,认为"肝郁脾虚"是其病机关键,"本虚标实"是病机特点,脾气亏虚、运化失常为发病之本,肝郁气滞、腑气不通为发病之标,治以运脾柔肝、理气通便,以运脾与柔肝并举、调气与导滞并重创建了运脾柔肝方,临床随证加减,治养相宜,配合穴位敷贴、生物反馈治疗等疗法,疗效显著.通过整理田耀洲教授以"运脾柔肝法"治疗功能性便秘之经验,以期为临床辨证治疗功能性便秘提供借鉴.

消化系统疾病作为临床医学中的一个重要疾病,包含食管、胃、肠、肝、胆、胰等的器质性和功能性疾病.文章研究表明,消化系统疾病的学习,需要将理论知识与临床实践有机结合,以往传统式的理论授课已不能满足此类要求,而案例式教学作为现代化教学改革的主要方法之一,通过案例库的构建与应用,为书本知识与临床实际搭建桥梁,进一步引导医学专硕学习的自主性、积极性,不仅有利于锻炼临床思维、提高解决临床现实问题的能力,还有利于研究生总体培养质量的提高,在医学专硕教学过程中具有重要的教学与实践意义.

Background The prognostic value of coiled-coil domain containing 68 (CCDC68) in colorectal cancer (CRC) is unclear. We evaluated the role of CCDC68 in CRC based on The Cancer Genome Atlas (TCGA) database. Methods Patients with CRC were collected from TCGA. We determined CCDC68 expression using the Wilcoxon rank sum test. Logistic analysis was applied to study the relationship between CCDC68 expression and clinicopathologic features. Cox regression and the Kaplan-Meier method were used to determine the predictive value of CCDC68 on clinical outcomes in CRC patients. Gene Set Enrichment Analysis (GSEA) and the single-sample Gene Set Enrichment Analysis (ssGSEA) were also conducted to annotate the biological function of CCDC68. Results Reduced CCDC68 expression in CRC was significantly correlated with N stage [odds ratio (OR) =0.95 for N1/N2 vs. N0], M stage (OR =0.91 for M1 vs. M0), pathologic stage (OR =0.95 for stage III/stage IV vs. stage I/stage II), neoplasm type (OR =0.92 for rectum adenocarcinoma vs. colon adenocarcinoma), tumor protein 53 (TP53) status [OR =0.93 for Mut (mutant) vs. WT (wild type)], and kirsten rat sarcoma viral oncogene (KRAS) status (OR =0.97 for Mut vs. WT) (all P values <0.05). Kaplan-Meier survival analysis showed that low CCDC68 expression had a poorer overall survival (OS) (P=0.008), progression-free interval (PFI) (P=0.006), and disease-specific survival (DSS) (P=0.023). Cox regression analysis revealed that CCDC68 was a risk factor for OS (P=0.047), PFI (P=0.048), and DSS (P=0.038). GSEA demonstrated that the chemokine signaling pathway, the Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathway, high-affinity IgE receptor (FcεRI)-mediated nuclear factor-κB (NF-κB) activation, cell adhesion molecules (CAMs), complement cascade, FcεRI-mediated mitogen-activated protein kinase (MAPK) activation, intestinal immune network for immunoglobulin A (IgA) production, and Toll-like receptor signaling pathway were differentially enriched in the high CCDC68 expression phenotype, while the Wnt signaling pathway was significantly enriched in the low CCDC68 expression phenotype. SsGSEA found that CCDC68 expression was positively correlated with T helper 2 (Th2) and T helper cells. Conclusions CCDC68 expression may be a potential prognostic molecular marker for poor survival in CRC. Moreover, CCDC68 may participate in the development of CRC via multiple signaling pathways.

目的 探讨品管圈管理在腹泻型肠易激综合征中西医结合整体护理中的应用效果.方法 选取2020年3月-11月该院消化科门诊腹泻型肠易激患者80例,其中品管圈实施前后各40例,对实施品管圈活动前后患者疾病知晓率及患者满意度进行分析和比较,进一步提高管理效果.结果 实施后患者疾病知晓率(95％)明显优于实施前(75％),存在统计学意义(P<0.05);实施后患者满意度达97.5％,显著高于实施前,差异有统计学意义(P<0.05).结论 通过品管圈活动的实施,能促进患者疾病知晓率,提高患者满意度.

Ethnopharmacological relevance: Aucklandia lappa Decne. (ALDE) is the general name for Asteraceae plants Yunmuxiang, which has traditionally been proven to have the ability in relieving depression by regulating qi, alleviating cold by warming, attenuating pain in stomach and relieving diarrhea in intestines. Therefore, ALDE is always recommended as an herbal remedy for gastrointestinal dysfunction.Aim of the study: The purpose of this study was to explore the therapeutic potential and mechanism of action of the sesquiterpene lactone-rich fraction (SLRF) of ALDE extracts, in the treatment of ulcerative colitis (UC) using a mouse model.Materials and methods: An aqueous extract and SLRF of ALDE were prepared. High performance liquid chromatography (HPLC) was used to determine the main components. The therapeutic effects of the extracts were evaluated using C57BL/6 mice treated with dextran sulfate sodium (DSS) to induce UC. Body weight, disease activity index (DAI), and colon length were recorded, and histopathological changes in the colon were characterized using hematoxylin and eosin (HE) staining. The anti-inflammatory activity of the two main sesquiterpene lactones in ALDE (costunolide and dehydrocostus lactone) were studied by quantitative proteomic analysis of treated RAW264.7 cells. Finally, based on bioinformatic analysis, we used polymerase chain reaction (PCR), immunofluorescence, and western blot experiments to verify the anti-inflammatory mechanism of the extracts in C57BL/6 mice.Results: The SLRF of ALDE significantly improved the pathological symptoms and inflammatory pathology of UC, whereas the aqueous extract had a weak protective effect. In RAW264.7 cells stimulated with lipopolysaccharide (LPS), costunolide and dehydrocostus lactone significantly reduced the mRNA levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, suggesting that these two sesquiterpene lactones had strong anti-inflammatory activity. Quantitative proteomics results indicated that the anti-inflammatory mechanism of these lactones may be the NF-κB/MAPK and Nrf2-Hmox-1 pathways. These results were further validated in SLRF-treated mice.Conclusion: This study confirmed that the SLRF of ALDE exerted protective activity against UC by regulating the Nrf2-Hmox-1, NF-κB, and MAPK pathways.

ABSTRACT:Primary lymphoma of the male breast is extremely rare. We describe FDG PET/CT findings in a man with primary breast lymphoma in his right breast. The breast tumor showed intense FDG uptake mimicking breast carcinoma.

Background:To assess the clinical feasibility of using effective atomic number (Zeff) maps derived from non-contrast-enhanced computed tomography (NCECT) scans obtained by dual-layer spectral computed tomography (DLCT) to identify non-calcified atherosclerotic plaques.Methods:A total of 37 patients with 86 non-calcified atherosclerotic plaques confirmed by contrast-enhanced CT (CECT) were enrolled in this retrospective study. Both spectral-based-images (SBI) and conventional images (CI) were reconstructed from NCECT and CECT scans. The presence of plaques on NCECT Zeff maps and CIs were independently assessed by 2 radiologists. In CECT scans, plaques and regions of interest (ROIs) in vessel lumens were assessed with CT attenuation and Zeff values, and the proportion of plaques was determined as Area (plaque)/Area (vessel). The CT and Zeff values for plaques and blood were recorded from both CECT and NCECT scans. Contrast-to-noise ratios (CNRs) of the plaques were calculated and compared using CT attenuation and Zeff values. Finally, interobserver agreement was evaluated.Results:A total of 47 of the 86 (54.7%) plaques were identified on Zeff map images derived from the NCECT scans while only 7 (8.1%) plaques were identified on the CI. There was no significant difference between the mean vessel ROI area measured on CIs and that measured on Zeff map images (502.19 vs. 498.14 mm2; P=0.28), while the mean plaque ROI area was larger (81.45 vs. 75.46 mm2). The observer consensus of vessel and plaque ROI area measurements using both methods was excellent, with interclass correlation coefficients (ICCs) of 0.99 and 0.94, respectively. For the 7 plaques detected both by NCECT CI and Zeff mapping, the CT attenuation and Zeff blood values were both larger than the plaque values [42.00 vs. 25.67 Hounsfield unit (HU); 7.33 vs. 7.19 HU; both P<0.05]; the plaque ROI area measurement on the NCE Zeff map was smaller than that on the CE CI (48.73 vs. 77.76 mm2), but was much larger than that on the NCE CI (18.39 mm2). For all 47 plaques detected by NCE Zeff mapping, the CT attenuation and Zeff values of blood and plaques on the NCECT images showed no significant differences (42.53 vs. 35.14 HU; P=0.18; 7.32 vs. 7.31, P=0.71); however, the CNR of Zeff was significantly higher than the CT attenuation value (1.69 vs. 1.12; P<0.05) derived from the NCECT scans. Inter-reviewer agreement was good (ICC =0.78).Conclusions:Zeff map images derived from NCECT SBI with DLCT provide a potentially feasible approach for identifying non-calcified atherosclerotic plaques, which might be clinically useful for the screening of asymptomatic at-risk patients.

腹泻型肠易激综合征(IBS-D)是消化系统常见疾病之一,反复发作严重影响了患者的生活质量,造成其沉重的经济负担,从而产生焦虑、抑郁等负面情绪,与疾病本身相互作用,恶性循环.近年来,中医药干预治疗伴有焦虑抑郁的IBS-D取得了一定的进展,而IBS-D作为一种社会-心理关系密切的身心疾病,焦虑抑郁等不良情绪可参与IBS-D的发病,IBS-D的胃肠道症状也可刺激中枢神经系统,从而产生情绪的异常,但目前IBS-D与情绪相关的机制仍需进一步的研究证实.中医通过辨证施治、专方治疗及外治法取得较好的临床疗效,可有效缓解患者的临床症状,且具有复发率低,不良反应少等优势,但目前本病的发病机制尚未明确,辨证分型标准尚未统一,存在临床研究的样本量较小,疗效评价患者主观性影响较大等局限性,在今后的研究中需进一步完善.通过对近年的文献学习,对中医药干预的伴焦虑抑郁的腹泻型肠易激综合征患者的诊疗现状进行探讨.