Objective To study the effect of advanced non small cell lung cancer by chemotherapy and its chemotherapeutic sensitivity. Methods The clinical data of 100 patients with advanced non-small cell lung cancer admitted in our hospital between June 2009 and July 2011 were randomly into four groups, receiving chemotherapy of TP、DP、GP、NP respectively. Five patients of them were detected by 9mTc-MIBI. The total effective rates and survival rates of the four groups by different chemotherapy regimens, and the relationship between curative effect and the positive showed by the imaging results, were observed. Results The treatment efficient of the TP and DT group was higher than that of the GP and NP group (40.0%, 40.0% vs 32.0%, 28.0%, and patients' survival rate was higher (44.0%, 48.0% vs 32.0%, 32.0%), too. Negative results by 9mTc-MIBI test could not rule out the possibility of disease. Conclusion The effective rates and survival rates of TP and DT is superior, and even if the 9mTc-MIBI test results were negative, relevant inspection programs or clinical observation is still needed.

Objective To investigate the methylation status of H-cadherin(CDH13) gene in colorectal cancer(CRC) and its clinical significance.Methods Eighty-five CRC specimens and tumor-adjacent normal tissues were selected,and the methylation status of CDH13 gene in the promoter region was detected by manual microdissection combined with methylation-specific PCR.Results The methylation frequency of CDH13 in the CRC tissues was 31.8%(27/85),which was significantly higher than 9.4%(8/85) in the tumor-adjacent normal tissues(P0.01).The methylation of CDH13 gene in the CRC tissues was associated with the poor differentiation(P0.05) and tended to be predominant in the advanced stages and lymph metastasis.Moreover,the methylation level of CDH13 gene was correlated with adverse overall survival(OS)(P0.01) and was an independent prognostic factor for OS.Conclusion The methylation of CDH13 gene may be a new biomarker for predicting the prognosis of CRC.