黄瓜花叶病毒（CMV）与番茄花叶病毒（ToMV）是引起番茄病毒病的两种重要病毒，本文首次报道了番茄上CMV对ToMV致病性的两种调控作用。具体表现为，合作903番茄上预先接种CMV对ToMV的再侵染产生强烈的干扰作用，中蔬4号番茄上进行相同实验发生协生作用。通过荧光定量RT-PCR技术检测两种作用中CMV和ToMV的积累量，发现病毒积累量与调控方式呈现一定的相关性，从病毒复制水平阐述了两种调控方式的分子机制。CMV与ToMV在番茄上两种作用方式的研究，对进一步探索病毒与病毒间的相互关系具有重要意义。

Abstract： Different interactions between CMV (Cucumber mosaic virus) and ToMV (Tomato mosaic virus) had been obtained in several tomato varieties. When tomato cv. Hezuo 903 plants were first inoculated with CMV-Fny, and then followed by a second inoculation with ToMV-N5 after 6-8 days, plants with co-infection expressed CMV-Fny-induced symptoms. The ToMV-N5-induced necrosis just localized on the inoculated leaves. Typical interference could be summarized for this phenomenon. Systemic necrosis induced by ToMV-N5 and interference between CMV-Fny and ToMV-N5 could occur in most tomato varieties (Hangza 1 and Zheza 809) except Zhongshu 4. They performed mild mosaic and synergism instead. The transcription of defense-related genes (PR-1a1 and PR-2) had been detected in tomato cv. Hezuo 903 plants among interference reaction. Results showed that two PR genes did not express in inoculated plants with mosaic and leaf deformation symptoms but was activated in ToMV-N5 infected plants with necrosis symptoms. It indicated that these two genes were effective with ToMV-N5 infection and could be interfered by pre-inoculation with CMV-Fny. Genotypes of resistance gene Tm2 in tomato cv. Zhongshu 4 and Hezuo 903 had been identified. Results revealed that two tomato varieties genotypes were both consistent with symptoms induced by ToMV-N5. It demonstrated that there may be a certain relationship between infection symptoms caused by ToMV-N5 on these two tomato varieties and genotype of Tm2.

Abstract： Cucumber mosaic virus (CMV) and Tomato mosaic virus (ToMV) are two principal viruses infecting tomato (Lycopersicon esculentum Mill). In this work, CMV-mediated regulations of diseases caused by ToMV in two tomato varieties were different. When tomato cv. Hezuo 903 plants were first inoculated with CMV-Fny, and then followed by a second inoculation with ToMV-N5 after 6-8 days, plants with co-infection expressed CMV-Fny-induced symptoms. The ToMV-N5-induced necrosis just localized on the inoculated leaves. Typical interference could be summarized for this phenomenon. Systemic necrosis induced by ToMV-N5 and interference between CMV-Fny and ToMV-N5 could not occur in another variety tomato cv.Zhongshu 4. They performed mild mosaic and synergism instead. Different ToMV-N5-induced symptoms in two varieties may be the primary reason of dissimilar ToMV-N5 infections mediated by CMV-Fny. Genotypes of resistance gene Tm2 in tomato cv. Hezuo 903 and Zhongshu 4 had been identified. Results revealed that two tomato varieties genotypes were both consistent with symptoms induced by ToMV-N5. Based on above results, we speculate that different genotypes of Tm2 may bring the difference of ToMV-N5-induced symptoms in two varieties, and this difference may lead dissimilar ToMV-N5 infections mediated by CMV-Fny.