Objective To test the effectiveness of melittin in chronic prostatic pain model. Methods Adult male Spraque-Dawley rats were injected with complete freunds adjuvant (CFA) into the prostate to make chronic prostatic inflammation. Melittin was injected into the prostates of these models 12 days later. The nociceptive effects were evaluated by using a behavior approach ( mechanical threshold measurement) at the 6th, 12th, and 18th day respectively after intraprostatic injection of CFA. The level of cyclooxygenase (COX-2) in prostate and glial fibrillary acidic protein (GFAP) expression in spinal cord were detected by immunohistochemistry. The rats in control group were injected with normal saline. Results CFA induced rats local allodynia, increases in inflammatory cell quantity and COX-2 expression in prostate, and GFAP expression in spinal cord. Melittin injection significantly raised pain mechanical threshold and decreased inflammatory cells quantity, COX-2 and GFAP expression as compared with control group. Conclusion Local injection of melittin can raise pain threshold, inhibit accumulation of inflammatory cells and expression of COX-2 and GFAP, produce some analgesic and anti-inflammatory effects in rat chronic prostate pain model.

目的:探讨前列腺素E1(PGE1)对慢性肾功能不全患者的肾保护作用.方法:测量我院3年来78例慢性肾功能不全患者用前PGE1治疗前后的肾功能、24 h 尿蛋白,并用彩色多普勒监测其肾血流变化.结果:78例经PGE1治疗后肾血流明显改善,肾功能好转,尿蛋白减少.结论:PGE1具有改善肾血流、保护慢性肾功能不全患者残肾功能效果显著且副作用小的优点,是治疗慢性肾功能不全的理想药物.