目的:研究外周血肿瘤异常糖链糖蛋白(tumor abnormal protein,TAP)的表达对早期肾癌的诊断价值.方法:对45例肾癌患者(肾癌组)、32例肾脏良性病变患者(肾良性病变组)和42例体检健康人群(正常组)的外周血TAP值进行分析;绘制受试者工作特征(receiver operating characteristics,ROC)曲线评估TAP对肾癌的诊断效能;分析肾癌组中TAP阳性表达与患者临床病理特征的关系.结果:肾癌组中外周血TAP水平明显高于肾良性病变组和正常组.通过评估TAP对肾癌的诊断效能,发现TAP诊断肾癌的ROC曲线下面积为0.92(95％CI:0.82～0.95),其诊断肾癌的灵敏度和特异度分别为73％和91％.结论:肾癌患者外周血中TAP呈高表达,可作为肾癌早期诊断的肿瘤标志物.

目的 探讨不同分期膀胱癌患者白蛋白与球蛋白比值(AGR)的临床意义.方法 收集2013年5月至2016年9月中国医科大学附属第四医院115例非肌层浸润性膀胱癌患者(NMIBC组)、36例肌层浸润性膀胱癌患者(MIBC组)以及49例正常健康体检者(对照组)临床资料.根据受试者工作特征(ROC)曲线确定NMIBC组、MIBC组术后出现复发及转移的AGR最佳截断值,根据最佳截断值比较不同分期膀胱癌患者的临床指标、3年无复发生存率及3年无瘤生存率.结果 3组两两比较AGR均存在统计学差异(均P<0.05).NMIBC组AGR与患者肿瘤分期、肿瘤大小及肿瘤分级相关(均P<0.05),低AGR组(AGR≤1.37)3年无复发生存率明显低于高AGR组(AGR>1.37,P<0.05).MIBC组AGR与患者肿瘤分期相关(均P<0.05),低AGR组(AGR≤1.33)3年无瘤生存率明显低于高AGR组(AGR>1.33,P<0.05).结论 AGR与膀胱癌肿瘤分期相关,低AGR患者的3年无复发生存率、3年无瘤生存率均低于高AGR患者.临床上AGR可作为评估不同分期膀胱癌预后的生物学标志物.

肾集合管癌又称为Bellini导管癌,是起源于肾髓质的罕见恶性肿瘤[1],发病率低,但恶性程度很高,预后较差.本文就1 例肾集合管癌进行病例报道并文献复习,现报告如下.

ObjectiveTo study the value of TAP expression in peripheral blood for early diagnosis of renal cell carcinoma.Materials and MethodsTAP expression was analyzed in the peripheral blood of 45 patients with renal cell carcinoma, 32 patients with benign renal lesions and 42 healthy patients. An analysis of the relationship between TAP expression and the clinicopathological features in renal cell carcinoma was performed; the ROC curve was used to evaluate the diagnostic efficacy of TAP detection for renal cell carcinoma diagnosis.ResultsTAP levels were significantly higher in RCC patients than in patients with nonneoplastic diseases. We also found that the rate of positive TAP expression in the peripheral blood of the renal cell carcinoma group showed no significant difference when evaluated by age, sex, histological grade, tumor stage, tumor size or tumor location (P > 0.05). The area under the ROC curve was 0.92 (95% CI: 0.82-0.95), and the sensitivity and specificity in the diagnosis of RCC was 73% and 91%, respectively.ConclusionsThe expression of TAP in peripheral blood of patients with renal cell carcinoma was significantly higher than that in nonneoplastic patients, which may provide an effective means of primary diagnosis for renal cell carcinoma