Dear Editor, Crimean-Congo hemorrhagic fever virus(CCHFV)causes severe viral hemorrhagic fever epidemics with a case fatality rate of up to 40％,and is a World Health Organization(WHO)priority pathogen.CCHFV,belonging to the family Nairoviridae in the class Bunyaviricetes,has a segmented negative-single-strand RNA genome,which is named as large(L),medium(M)and small(S)segment according to their size.The M segment encodes the glycoprotein precursor(GPC),and the GPC is further cleaved into five proteins,including N-terminal mucin like domain(MLD),glycoprotein 38(GP38),glycoprotein N(Gn),nonstructural protein m(NSm),and glycoprotein C(Gc)(Hawman and Feldmann,2023).Gn and Gc anchor in the virion membrane via their C-terminal transmembrane regions.As a class Ⅱ membrane fusion pro-tein(Li et al.,2022;Mishra et al.,2022),Gc mediates the membrane fusion between viral membrane and host cell membrane,while Gn may act as a chaperone protein to cover the fusion loop of Gc and control where and when the fusion occurs(Guardado-Calvo and Rey,2021).

Efficient mineralization of volatile organic compounds (VOCs) during photothermocatalysis fundamentally relies on the efficiency of photogenerated carriers participating in surface charge transfer reactions and the sustained generation of reactive oxygen species (ROS). However, systematic insights into how spatial modulation of active sites regulates these two critical processes remain limited. In this work, grain boundary engineering was applied to ceria-based catalysts to modulate the local defect environment, enabling a comprehensive understanding of how spatial distribution of asymmetric oxygen vacancies (ASOv) governs continuous activation of O2 and lattice oxygen (Olatt) during reactions. Experimental results demonstrate that coexistence of small and large Ov clusters in monocrystalline Cu/M-Ce leads to two spatial distributions of Cu species—interfacial dispersion and bulk-incorporated, whereas polycrystalline Cu/P-Ce features primarily small Ov clusters with interfacially dispersed Cu. Rigorous investigations of the superior photoreactivity and dual activation of O2 and Olatt indicate that interfacial sites Cu+int-Ov-Ce3+ exhibit a higher ROS generation capability than bulk-incorporated Cu+bulk-Ov-Ce3+, accelerating the ring-opening process of toluene. This work provides a broadly applicable strategy and theoretical basis for boosting oxygen activation in pollutants degradation, and reveals the eco-economic benefits of photothermocatalysis through techno-economic assessment.

ABSTRACT The emergence of novel variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to pose an ongoing challenge for global public health services, highlighting the urgent need for effective therapeutic interventions. Neutralizing monoclonal antibodies (mAbs) are a major therapeutic strategy for the treatment of COVID-19 and other viral diseases. In this study, we employed hybridoma technology to generate mAbs that target the BA.5 receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. Through a comprehensive screening process, we identified four mAbs capable of effectively neutralizing BA.5, XBB.1.16, and related variant infections in vitro , among which ORB10 was found to neutralize BA.5 variants with a plaque reduction neutralization test (PRNT 50 ) of 8.7 ng/mL. Additionally, competitive binding assays, sequencing of heavy and light chain variable regions, and binding kinetics characterization provided insights into the epitopes and binding affinities of the identified mAbs. Moreover, in vivo experiments in the K18-hACE2 mouse model demonstrated the protective efficacy of ORB10 against both BA.5 and XBB.1.16 variants. Finally, cryo-electron microscopy structural analysis of the ORB10–RBD complex identified key residues involved in the antibody–antigen interactions, providing insights into the molecular mechanisms of neutralization and immune escape of SARS-CoV-2 Omicron variants from mAbs. IMPORTANCE The ongoing evolution of SARS-CoV-2 has led to the emergence of variants capable of evading immune responses elicited by natural infection and vaccination, especially the highly transmissible and immune-evasive Omicron variants. This study generated and characterized a panel of monoclonal antibodies (mAbs) specifically targeting the RBD of the Omicron BA.5 variant, of which the ORB10 showed efficacy against Omicron BA.5 and XBB.1.16 variants both in vitro and in vivo . Cryo-EM structural analysis further elucidated the binding epitope interactions and neutralization mechanism between ORB10 and the BA.5 RBD protein. This study enhances our understanding of antibody-mediated neutralization of SARS-CoV-2 and provides valuable insights into the development of effective therapeutic strategies to combat ongoing SARS-CoV-2 variant infections.

In this study, In2S3/PI Z-scheme heterojunctions composite photocatalysts were synthesized via a hydrothermal technique and employed to degrade tetracycline hydrochloride under the action of visible light. The enhancement of their performance was achieved by combining organic and metallic materials. The In2S3/PI heterojunction with 20 wt% In (20In2S3/PI), demonstrated the highest efficiency in target compound (TC) degradation, with a rate of 88%, i.e., 86% and 38% higher than that of PI and In2S3, respectively, over 180 min. This remarkable photocatalytic performance was due to the enhanced charge separation and decreased electron-hole pair recombination, through the formation of a diverse structure. The high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, radical trapping, and electron paramagnetic resonance spectroscopy analyses verified the above speculation. Compared to pure PI and In2S3, the composite photocatalyst exhibited a superior generation of active species, i.e., center dot O2- and h+, along with a higher capacity for mineralization. Furthermore, high-performance liquid chromatography-mass spectrometry analysis was performed to examine the possible pathways for the photocatalytic degradation of TC by the In2S3/PI composites. The findings of this study provide a novel approach to TC degradation.

A round-the-clock photocatalyst that can efficiently separate charge carriers will break through the practical application of photocatalytic-based advanced oxidation processes (PC-AOPs) in wastewater treatment. In this work, an energy-storable p-n heterojunction Ag2O@SrAl2O4:Eu2+,Dy3+ (Ag2O@SAED) was successfully prepared to achieve round-the-clock photocatalytic degradation of ciprofloxacin (CIP). Ag2O@SAED can efficiently degrade similar to 80 % of CIP (with similar to 56 % mineralization) under low power consumption of 12 W LED visible light source radiation for 2 h. In addition, surprisingly, Ag2O@SAED also shows certain energy storage properties, so that it can effectively reduce the energy consumption of the treatment process compared with conventional photocatalytic processes. Non-radical singlet oxygen (O-1(2)) is the main reactive species, which is produced mainly from intermediate superoxide radicals (center dot O-2(-)). Moreover, the site of CIP attacked by O-1(2) was tentatively confirmed by Fukui index based on density functional theory (DFT) calculations. The activities of round-the-clock degradation of CIP in different water matrices were examined. The degradation efficiency in tap water, Yangtze River and wastewater plant effluent were 61.88 %, 57.61 % and 55.87 %, respectively. The synergistic effect of p-n heterojunctions is effective in degrading CIP during daytime, and the light released from SAED activates the activity of Ag2O to degrade CIP at night. This study contributes to further understanding the principles and mechanisms of round-the-clock photocatalysts for degradation of organic pollutants and provides directions for the practical application of photocatalytic technology.

Heterojunction organic-inorganic composites are promising for wastewater treatment due to their excellent physical and chemical properties. ZnO was immobilized on the PI surface using the hydrothermal technique to prepare PI/ZnO n-n heterojunctions with outstanding visible photocatalytic properties. The photocatalytic performance of different ratios of PI/ZnO composites was significantly improved in comparison to pure PI and ZnO, among which 40% PI/ZnO showed the most outstanding results. The 40% PI/ZnO can adsorption remove around 40% of tetracycline (TC) in 20 min in entirely shaded conditions and can attain up to 90% of the TC removal efficiency in 40 min under visible light exposure. The formation of a PI/ZnO heterojunction enhances the efficiency of charge separation and reduces the recombination of photogenerated electron-hole pairs, resulting in improved photocatalytic performance. Meanwhile, the 40% PI/ZnO composites showed a substantial increase in specific surface area (205.22 m2/g) compared to pure PI and ZnO, which was 103 and 25 times that of PI and ZnO, respectively. The increase in surface area provided a larger number of adsorption sites, thereby increasing the contact area between the pollutants and the photocatalysts, which led to a significant improvement of the PI/ZnO composites in the adsorption and photocatalytic properties. In this study, the heterojunction was formed by the composite of conjugated polymer and metal oxide, so that the composites could remove the organic matter more efficiently by adsorption and then photocatalysis, which will provide some ideas for the development of more efficient conjugated polymer materials.

Breaking through the inherent thinking, activating insulators with abundant and economical sources as photocatalysts to promote the practical application of photocatalysis has attracted attention. Herein, an insulator photocatalyst barium silicate (BSO) was successfully prepared by the hydrothermal method, and a solid-liquid photocatalytic reaction system combining solid-phase photocatalyst with liquid-phase antibiotic photosensitizer was constructed. In this reaction system, the insulator BSO achieved excellent photocatalytic activity, and the degradation of 30 mg/L tetracycline reached 93.2 % after 12 W LED illumination for 2 h. The mechanism of tetracycline as a liquid-phase photosensitizer to activate the photocatalytic activity of BSO was explored. Lewis acid-base interaction not only alkalizes tetracycline to expand BSO light absorption, but also constitutes an electron transport channel between the BSO and alkalization tetracycline to facilitate the separation of photogenerated carriers. Alkalized tetracycline as a photosensitizer improves the response of BSO to visible light, and is decomposed by active substances such as O-1(2) and center dot O-2(-), thereby purifying the water body. This work reveals for the first time the mechanism of action of antibiotic photosensitizers to activate the photocatalytic activity of insulators, and provides a new perspective for the activation and development of insulators in photocatalysis.

The application of collagen-based hydrogel is severely restricted due to its poor mechanical strength and functional singleness. In this paper, two-dimensional MXene nanosheets were introduced into collagen/ acrylic acid (AA) system, which was polymerized in situ to produce versatile hydrogel (GCol-MX-PAA). The tensile stress and compressive stress values of the resultant hydrogel at the MXene concentration of 5 mg/mL reached 211.5 kPa and 7.8 MPa, respectively, which were approximately 4.0 and 1.4 times higher than those of GCol-PAA. The bonding strength of the hydrogel reached 30.7 kPa in the porcine skinadhesive model owing to the large number of free phenolic hydroxyl groups on GCol. Furthermore, GCol-MX-PAA could be applied to monitor large and subtle activities of human body due to the excellent electrical conductivity of MXene. Thanks to the outstanding photothermal conversion performance of MXene, the hydrogel could kill E. coli and S. aureus effectively under NIR irradiation. In addition, in vitro cytotoxicity test performed on L929 fibroblasts demonstrated the desirable biocompatibility of GCol-MX-PAA. The design strategy in this work gives guidance for the development of multifunctional collagen-based hydrogel in a wide range of applications.

BackgroundThe long-term health consequences of COVID-19 remain largely unclear. The aim of this study was to describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the associated risk factors, in particular disease severity.MethodsWe did an ambidirectional cohort study of patients with confirmed COVID-19 who had been discharged from Jin Yin-tan Hospital (Wuhan, China) between Jan 7, 2020, and May 29, 2020. Patients who died before follow-up, patients for whom follow-up would be difficult because of psychotic disorders, dementia, or re-admission to hospital, those who were unable to move freely due to concomitant osteoarthropathy or immobile before or after discharge due to diseases such as stroke or pulmonary embolism, those who declined to participate, those who could not be contacted, and those living outside of Wuhan or in nursing or welfare homes were all excluded. All patients were interviewed with a series of questionnaires for evaluation of symptoms and health-related quality of life, underwent physical examinations and a 6-min walking test, and received blood tests. A stratified sampling procedure was used to sample patients according to their highest seven-category scale during their hospital stay as 3, 4, and 5–6, to receive pulmonary function test, high resolution CT of the chest, and ultrasonography. Enrolled patients who had participated in the Lopinavir Trial for Suppression of SARS-CoV-2 in China received severe acute respiratory syndrome coronavirus 2 antibody tests. Multivariable adjusted linear or logistic regression models were used to evaluate the association between disease severity and long-term health consequences.FindingsIn total, 1733 of 2469 discharged patients with COVID-19 were enrolled after 736 were excluded. Patients had a median age of 57·0 (IQR 47·0–65·0) years and 897 (52%) were men. The follow-up study was done from June 16, to Sept 3, 2020, and the median follow-up time after symptom onset was 186·0 (175·0–199·0) days. Fatigue or muscle weakness (63%, 1038 of 1655) and sleep difficulties (26%, 437 of 1655) were the most common symptoms. Anxiety or depression was reported among 23% (367 of 1617) of patients. The proportions of median 6-min walking distance less than the lower limit of the normal range were 24% for those at severity scale 3, 22% for severity scale 4, and 29% for severity scale 5–6. The corresponding proportions of patients with diffusion impairment were 22% for severity scale 3, 29% for scale 4, and 56% for scale 5–6, and median CT scores were 3·0 (IQR 2·0–5·0) for severity scale 3, 4·0 (3·0–5·0) for scale 4, and 5·0 (4·0–6·0) for scale 5–6. After multivariable adjustment, patients showed an odds ratio (OR) 1·61 (95% CI 0·80–3·25) for scale 4 versus scale 3 and 4·60 (1·85–11·48) for scale 5–6 versus scale 3 for diffusion impairment; OR 0·88 (0·66–1·17) for scale 4 versus scale 3 and OR 1·77 (1·05–2·97) for scale 5–6 versus scale 3 for anxiety or depression, and OR 0·74 (0·58–0·96) for scale 4 versus scale 3 and 2·69 (1·46–4·96) for scale 5–6 versus scale 3 for fatigue or muscle weakness. Of 94 patients with blood antibodies tested at follow-up, the seropositivity (96·2% vs 58·5%) and median titres (19·0 vs 10·0) of the neutralising antibodies were significantly lower compared with at the acute phase. 107 of 822 participants without acute kidney injury and with estimated glomerular filtration rate (eGFR) 90 mL/min per 1·73 m2 or more at acute phase had eGFR less than 90 mL/min per 1·73 m2 at follow-up.InterpretationAt 6 months after acute infection, COVID-19 survivors were mainly troubled with fatigue or muscle weakness, sleep difficulties, and anxiety or depression. Patients who were more severely ill during their hospital stay had more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, and are the main target population for intervention of long-term recovery.FundingNational Natural Science Foundation of China, Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences, National Key Research and Development Program of China, Major Projects of National Science and Technology on New Drug Creation and Development of Pulmonary Tuberculosis, and Peking Union Medical College Foundation.

Combining mesoporous structure and defect engineering is an effective way to optimize the photocatalytic activity of graphitic carbon nitride. Herein, a unique N-deficient mesoporous carbon nitride (nmpg-C3N4), constructed by silica-template method, possesses efficient and stable photocatalytic purification of NO, far exceeding the bulk carbon nitride (B-C3N4). In nmpg-C3N4, the mesoporous structure not only exposes more active sites, but also the resulting quantum confinement effect widens the band gap of nmpg-C3N4 and enhances its redox ability. While N defects constitute catalytic active sites and induces effective separation of photogenerated carriers. Under the synergistic effect of mesoporous structure and defect engineering, nmpg-C3N4 produces more •O2− and •OH to remove NO in the air. Its photocatalytic activity reaches 60.61% higher than B-C3N4 (35.51%) and exposes better stability. Moreover, a reasonable NO purification path was proposed using in-situ DRIFTS technology. Our research proves that utilizing the quantum confinement effect of mesoporous materials combined with defect engineering can effectively extend the energy band and make the catalyst have more active sites. This study provides new enlightenment for the modification of carbon nitride.

Neutralizing monoclonal antibodies (mAb) are a major therapeutic strategy for the treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The continuous emergence of new SARS-CoV-2 variants worldwide has increased the urgency for the development of new mAbs. In this study, we immunized mice with the receptor-binding domain (RBD) of the SARS-CoV-2 prototypic strain (WIV04) and screened 35 RBD-specific mAbs using hybridoma technology. Results of the plaque reduction neutralization test showed that 25 of the mAbs neutralized authentic WIV04 strain infection. The 25 mAbs were divided into three categories based on the competitive enzyme-linked immunosorbent assay results. A representative mAb was selected from each category (RD4, RD10, and RD14) to determine the binding kinetics and median inhibitory concentration (IC50) of WIV04 and two variants of concern (VOC): B.1.351 (Beta) and B.1.617.2 (Delta). RD4 neutralized the B.1.617.2 variant with an IC50 of 2.67 ​ng/mL; however, it completely lost neutralizing activity against the B.1.351 variant. RD10 neutralized both variants with an IC50 exceeding 100 ​ng/mL; whereas RD14 neutralized two variants with a higher IC50 (>1 ​mg/mL). Animal experiments were performed to evaluate the protective effects of RD4 and RD10 against various VOC infections. RD4 could protect Adv-hACE2 transduced mice from B.1.617.2 infection at an antibody concentration of 25 ​mg/kg, while RD10 could protect mice from B.1.351 infection at an antibody concentration of 75 ​mg/kg. These results highlight the potential for future modifications of the mAbs for practical use.

A ZnSn(OH)6/SrSn(OH)6 perovskite-structured hydroxide heterojunction was constructed by a simple one-pot hydrothermal method and applied to degrade toluene under UV light. The optimal sample 20% ZnSn(OH)6/SrSn(OH)6 heterojunction (named 20% ZSH/SSH) exhibits a toluene degradation rate of 86.55%, which is 26.34% and 20.13% higher than that of SrSn(OH)6 and ZnSn(OH)6 for 30 min, respec-tively. The ESR shows that center dot OH and center dot O2- generated in the SrSn(OH)6/ZnSn(OH)6 system acted as the main reactive radical to induce the degradation of toluene. Moreover, the degradation process of toluene was also investigated by In-situ DRIFTS, which demonstrates a pathway that ZnSn(OH)6/SrSn(OH)6 could promote the conversion of toluene to benzyl alcohol, benzaldehyde, benzoic acid, and then mineralized to H2O and CO2. This work offers a promising approach for building perovskite-structured hydroxide heterojunction by a simple one-pot hydrothermal method to improve photocatalytic performance for reducing indoor air contamination.(c) 2023 Published by Elsevier B.V.

Under the new crown pneumonia (COVID-19) epidemic, the intensive use of therapeutic drugs has caused certain hidden danger to the safety of the water environment. Therefore, the core-shell microporous zinc silicate (SiO2@ZSO) was successfully prepared and used for the adsorption of chloroquine phosphate (CQ), tetracycline (TC) and ciprofloxacin (CIP) for eliminating the threat of COVID-19. The adsorption efficiencies of 20 mg L-1 of CQ, TC and CIP by SiO2@ZSO were all up to 60% after 5 min. The adsorption capacity of SiO2@ZSO for CQ, TC and CIP can reach 49.01 mg g-1, 56.06 mg g-1 and 104.77 mg g-1, respectively. The adsorption process is primarily physical adsorption, which is heterogeneous, spontaneous and preferential. Moreover, the effects of temperature, pH, salinity, and reusability on the adsorption of CQ, TC, and CIP on SiO2@ZSO were investigated. The adsorption mechanism mainly involves electrostatic attraction, partitioning and hydrogen bonding, which is insightful through the changes of the elements and functional groups before and after adsorption. This work provides a solution to the problems faced by the treatment of pharmaceuticals wastewater under the COVID-19 epidemic.

Nowadays, heterojunction materials are of great interest in photocatalytic degradation studies of organic pollutants owing to their high separation efficiency from photogenerated carriers. In this study, BiOIO3/BiOBr n-n type heterojunctions were successfully synthesized and used for photocatalytic degradation of TC. Under visible light, the degradation rate of the 10%BiOIO3/BiOBr heterojunction reached 74.91% after 80 min irradiation, which was 26.79% and 22.67% higher than that of pure BiOBr and BiOIO3, respectively. The formation of BiOIO3/BiOBr n-n type heterojunction enhanced the light absorption ability, and the internal electric field formed between them accelerated the electron-hole pairs separation and transfer, thus enhancing the photocatalytic activity, which was confirmed by UV-Vis DRS, electrochemical and PL spectrum tests. Meanwhile, as confirmed by SEM and TEM, the BiOIO3/BiOBr heterojunction adheres face to face, and the large and tight contact area provides more channels for electron migration. Moreover, the active species that take part in the photocatalytic reaction were identified as center dot O2- and h+ by radical trapping experiments. According to the HPLCMS test, the possible photocatalytic degradation pathways of TC were investigated. Finally, the charge transfer mechanism of BiOIO3/BiOBr n-n heterojunction is proposed. This study may offer a design pathway for constructing visible light responsive bismuth-based heterojunction materials and may also provide some ideas for solving the growing problem of antibiotic contamination.

Silica (SiO2) is one of the most promising inorganic nanofillers, and it has been widely used in the preparation of polymer nanocomposites due to its adjustable morphology, large specific surface area, and ease of functionalization. The surface modification, structural characteristics, and bonding mechanisms of SiO2 are crucial in enhancing the overall performance of polymer nanocomposites. This review focuses on summarizing the recent progress made regarding the preparation and structure characterization methods, unique properties, and rheological behavior of SiO2/polymer nanocomposites. In addition, the latest applications of SiO2/polymer nanocomposites in coatings, smart devices, biomedicine, and environment are further explored. A comprehensive summary of the main challenges, opportunities, and perspectives regarding SiO2/polymer nanocomposites is also presented.

The prevention of grain storage pests is a universal concern all over the world. It is in high demand to explore novel, safe and green insecticidal techniques to address such concerns. In this work, both raw and calcined diatomite were used as a natural insecticide to remove common grain storage pests with improved lethal effect on the saw-toothed grain beetle. Interestingly, the raw diatomite showed higher insecticidal efficiency than the calcined diatomite, and its associated insecticidal properties and preparation conditions were also optimized through orthogonal tests. The optimal conditions for processing the raw diatomite insecticide were identified as follows: the diatomite dust was 500 mesh (A 3), the temperature was 25 °C (B 1), the relative humidity was 65% (C 2), the diatomite dosage was 20 g m-2 (D 2), the influence factor order was C ≥ D > A > B. The observation of surface morphology indicated that the raw diatomite had a complete, multi hole surface morphology and good adsorption performance, whereas the structure of the calcined diatomite was uncomplete with collapsed pores, resulting in poor adsorption performance. The special pore structure and excellent adsorption capacity of diatomite make the stored grain pests lose water to lethal effect. Acute toxicity and long-term toxicity tests in mice showed that diatomite has no harmful effects on mammals. The findings from our work led to a green and effective approach in producing a highly efficient and safe storage grain insecticide.

In this paper, a novel NaLa(WO4)(2)/g-C3N4 photocatalyst with Z-scheme heterojunction was synthesized for the first time, and the photocatalytic purification of NOx was used as an evaluation method of its activity. The structure was analyzed in depth by X-ray Diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and other characterization methods. NaLa(WO4)(2) and g-C3N4 have obvious interfaces and successfully constructed a Z-scheme heterojunction structure. The combination of photogenerated electrons on the conduction band (CB) of NaLa (WO4)(2) with holes on the valence band (VB) of g-C3N4 leads to the accumulation of the remaining holes and electrons on the VB of NaLa(WO4)(2) and CB of g-C3N4, and finally realizes the effective separation of photogenerated carriers and maintains the high redox ability of the catalyst. The NaLa(WO4)(2)/g-C3N4 composite catalyst has a highest NO purification rate of 47.18%, which is 16.51% higher than pure g-C3N4. Moreover, the In-situ DRIFTS monitors the reaction intermediates and final products of NO on the NaLa(WO4)(2)/g-C3N4 heterojunction surface under visible light irradiation, and provides the corresponding reaction equations. This work provides a new type of photocatalyst that is easy to prepare and highly active, as well as a low-cost photocatalytic treatment technology to remove NO in the environment. (c) 2022 Elsevier B.V. All rights reserved.

Several 2D nanosheets of porphyrin MOFs with various transition-metal clusters as metal nodes were prepared via a simple solvothermal method to apply in the photocatalytic hydrogen evolution, in which the hydrogen production rate of the optimal NS-Cu was as high as 15.39 mmol g(-1) h(-1). A series of experimental technologies especially cyclic voltammetry (CV) and Mott-Schottky (M-S) had been adopted to investigate the charge-transfer property of photo-generated electron-hole pairs, it was found that the uniformly dispersed Cu-clusters nodes in the original 2D MOFs played a key role in the electron transfer process, that was, the photo-generated electron transferred from excited state eosin-Y to the Cu-clusters nodes for the efficient hydrogen evolution. The excellent photocatalytic performance could be attributed to the reversible oxidation--reduction process of Cu-II/Cu-I, which had excellent electron-receiving and electron-outputting capabilities. Our results provided a novel avenue to adapt the uniformly dispersed metal nodes in the original MOFs as cost-effective noble-metal-free cocatalysts with very high atomutilization efficiency to improve the photocatalytic hydrogen evolution performance in dye-sensitized system. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

A novel solid bi-amine adsorbent was synthesized by simultaneously impregnating pentaethylenehexamine (PEHA) and aminoethylethanolamine (AEEA) on the surfaces of mesoporous MCM-41 nanospheres. AEEA and PEHA had a synergistic effect during the CO2 adsorption of the bi-amine adsorbent and the highest CO2 adsorption capacity was 4.03 mmol.g(-1). The bi-amine adsorbent exhibited the favorable recyclability because its saturated CO2 adsorption capacity decreased by 6.20 % after the initial eight adsorption/desorption cycles while by only 2.23 % in the following seven cycles. The adsorption activation energy and the desorption activation energy were determined to be 12.53 and 16.81 kJ.mol(-1), respectively. The low value of the desorption activation energy suggested an inconsiderable energy requirement in the multicycles of the adsorbent. The characterization results indicated that hydrogen bonds were formed between the hydrogen atom in hydroxyl groups of AEEA and the oxygen atom in carbonyl groups of the carbamate. The synergistic effect between AEEA and PEHA was unveiled on the CO2 adsorption of the bi-amine adsorbent. The formed hydrogen bonds facilitated the release of protons from carbamic acids, enhanced the stability of the produced carbamate anions, and thus boosted the CO2 adsorption performance.

Objective: Critical covid-19 patients have complications with acute myocardial injury is still unclear. We observed a series of critically ill patients, paying particular attention to the impact of myocardial injury at admission on short-term outcome. Methods: We prospectively collected and analyzed data from a series of severe covid-19 patients confirmed by real-time RT-PCR. Data were obtained from electronic medical records including clinical charts, nursing records, laboratory findings, and chest x-rays were from Feb 8, 2020, to April 7, 2020. The Acute Physiology and Chronic Health Evaluation (APACHE II) score, CURB-65 Pneumonia Severity Score, Sequential Organ Failure Assessment (SOFA) Score and pneumonia severity index (PSI) score were made within 24 hours of admission. Cardiac injury was diagnosed as hs-cTnI were above >28 pg/mL. The short-term outcome was defined as mortality in hospital. Results: A total of 100 patients met the diagnostic criteria of severe patients with COVID-19 during 2020.02.08-2020.04.07. The CURB 65, APACH2, SOFA, and PSI score were significantly higher in Critical group than in Severe group. Univariate regression analysis showed that oxygen flow, PO2/FiO2, SOFA and hs-cTnI were closely related to short-term outcome. The corresponding ROC of hs-cTnI, oxygen flow and SOFA for patient death prediction were 0.949, 0.906 and 0.652. hs-cTnI at 47.8 ng/liter predicted death, sensitivity 92.8%, specificity 92.9%; Oxygen flow at 5.5 liter/minute predicted death sensitivity 100%, specificity 77.9%; SOFA score at 5 predicted death sensitivity 100%, specificity 73.8%. Conclusion: Our cohort study demonstrated that inhaled oxygen flow, SOFA score, and myocardial injury at admission in critically ill COVID-19 patients were important indicators for predicting short-term death of patients, the hs-cTnI can be as a risk stratification, which provide a simple method for the to patients and reasonable treatment in time.