Aksenova, A.; Litvin, A.; Galitsin, P.; Bugriy, M.; Elfimova, E.; Bolotova, M.; Sergienko, V.; Chazova, I. Author Information

Objective: To explore opportunities to improve perfusion of the brain in hypertensive and obesity patients (pts) after 6 months therapy. Design and Methods: The study sample consisted of 45 pts. They all had moderate hypertension (SBP = 153 ± 11 mm Hg; DBP = 93 ± 9 mm Hg) and obesity (body mass index 35 ± 5). All patients underwent overnight polysomnography (EMBLA Flaga (Iceland)). They were divided into three groups (gr). Gr.I and gr.II had severe OSAHS, apnea-hypopnea index (AHI 56 ± 23), gr III without OSAHS. Continuous positive airway pressure therapy (CPAP) was administered to 17 patients of gr.I. Gr.II (11 pts) hadn't received CPAP therapy. All pts received the same antihypertensive therapy. rCBF was analyzed in 8 regions of interests by Ceretec-99 M on single photon emission tomography (SPECT) in initial phase and after 6 months of therapy.Patients of first gr. had significantly increased cerebral blood flow in all regions of interests after 6 months of therapy (p < 0.0001). Patients of second gr (p < 0.05) and third gr. (p < 0.0001) had increased rCBF only in temporal lobes. Conclusions: CPAP-therapy improves regional cerebral blood flow in patients with moderate hypertension, obesity and severe OSAHS.