M. Date

2RIFM Fragrance Ingredient Safety Assessment, Dihydromyrcenol, CAS Registry Number 18479-58-8

A. M. Api,D. Belsito,D. Botelho,M. Bruze, G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

• Dihydromyrcenol; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC.

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3RIFM Fragrance Ingredient Safety Assessment, 2-Ethylbutyric Acid, CAS Registry Number 88-09-5

A. M. Api,D. Belsito,S. Biserta,D. Botelho,M. Bruze,G. A. Burton,J. E. Buschmann,M. A. Cancellieri,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,

•2-Ethylbutyric acid; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

2024Food and Chemical Toxicology（2024）引用：2

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4Update to RIFM Fragrance Ingredient Safety Assessment, P-Tolyl Alcohol, CAS Registry Number 589-18-4

A.M. Api,D. Belsito,S. Biserta,D. Botelho,M. Bruze,G.A. Burton,J. Buschmann,M.A. Cancellieri,M.L. Dagli,M. Date,W. Dekant,C. Deodhar,

• p -Tolyl alcohol; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC.

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5Update to RIFM Fragrance Ingredient Safety Assessment, 2-Methylbutanol, CAS Registry Number 137-32-6.

A. M. Api,D. Belsito,D. Botelho,M. Bruze,G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

• 2-Methylbutanol; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC.

2024FOOD AND CHEMICAL TOXICOLOGY（2024）

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6RIFM Fragrance Ingredient Safety Assessment, 3-Methylpentanoic Acid, CAS Registry Number 105-43-1

A. M. Api,D. Belsito,S. Biserta,D. Botelho,M. Bruze,G. A. Burton, J. Buschmann,M. A. Cancellieri,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,

•3-Methylpentanoic acid; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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7RIFM Fragrance Ingredient Safety Assessment, 2-Sec-butylcyclohexanone, CAS Registry Number 14765-30-1.

A. M. Api,D. Belsito,D. Botelho,M. Bruze, G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•2-sec-Butylcyclohexanone; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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8RIFM Fragrance Ingredient Safety Assessment, Cyclohexaneethanethiol, 3-Mercapto-b,4-dimethyl-, CAS Registry Number 4802-20-4.

A. M. Api,D. Belsito,D. Botelho,M. Bruze, G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•Cyclohexaneethanethiol, 3-mercapto-b,4-dimethyl-; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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9RIFM Fragrance Ingredient Safety Assessment, Cyclohexanone,5-Methyl-2-(1-methylethyl)-,oxime, CAS Registry Number 19096-86-7.

A. M. Api,D. Belsito,D. Botelho,M. Bruze,G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•Cyclohexanone,5-methyl-2-(1-methylethyl)-,oxime; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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10RIFM Fragrance Ingredient Safety Assessment, Geranyl Isovalerate, CAS Registry Number 109-20-6.

A. M. Api,D. Belsito,D. Botelho,M. Bruze, G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•Geranyl isovalerate; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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11RIFM Fragrance Ingredient Safety Assessment, Acetyl Cedrene, CAS Registry Number 32388-55-9.

A. M. A. Api, D. B. Belsito, D. A. Botelho,M. C. Bruze,G. A. JrD Burton,M. A. A. Cancellieri,H. A. Chon, M. L. E. Dagli,M. A. Date,W. F. Dekant,C. A. Deodhar,A. D. G. Fryer,

•Acetyl cedrene; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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12RIFM Fragrance Ingredient Safety Assessment, 3-Methyl-2-buten-1-ol, CAS Registry Number 556-82-1.

A. M. Api,D. Belsito,D. Botelho,M. Bruze,G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•3-Methyl-2-buten-1-ol; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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13RIFM Fragrance Ingredient Safety Assessment, Ethyl Valerate, CAS Registry Number 539-82-2.

A. M. Api,D. Belsito,D. Botelho,M. Bruze, G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•Ethyl valerate; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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14RIFM Fragrance Ingredient Safety Assessment, 11-Oxahexadecanolide, CAS Registry Number 3391-83-1.

A. M. Api,D. Belsito,D. Botelho,M. Bruze,G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•11-Oxahexadecanolide; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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15RIFM Fragrance Ingredient Safety Assessment, Α-Methylbenzyl Isobutyrate, CAS Registry Number 7775-39-5.

A. M. Api,D. Belsito,D. Botelho,M. Bruze, G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•α-Methylbenzyl isobutyrate; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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16RIFM Fragrance Ingredient Safety Assessment, 2-Methylpropyl 2-Methylbutyrate, CAS Registry Number 2445-67-2.

A. M. Api,D. Belsito,D. Botelho,M. Bruze, G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•2-Methylpropyl 2-methylbutyrate; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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17RIFM Fragrance Ingredient Safety Assessment, Geranyl Butyrate, CAS Registry Number 106-29-6.

A. M. Api,D. Belsito,D. Botelho,M. Bruze, G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•Geranyl butyrate; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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18RIFM Fragrance Ingredient Safety Assessment, Allyl Cyclohexaneacetate, CAS Registry Number 4728-82-9.

A. M. Api,D. Belsito,D. Botelho,M. Bruze, G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•Allyl cyclohexaneacetate; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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19RIFM Fragrance Ingredient Safety Assessment, Diethyl 1,4-Cyclohexane Dicarboxylate, CAS Registry Number 72903-27-6.

A. M. Api,D. Belsito,D. Botelho,M. Bruze, G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

•Diethyl 1,4-cyclohexane dicarboxylate; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or TTC.

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20RIFM Fragrance Ingredient Safety Assessment, 6,6-Dimethoxy-2,5,5-trimethylhex-2-ene, CAS Registry Number 67674-46-8

A. M. Api,D. Belsito,D. Botelho,M. Bruze,G. A. Burton,M. A. Cancellieri,H. Chon,M. L. Dagli,M. Date,W. Dekant,C. Deodhar,A. D. Fryer,

• 6,6-Dimethoxy-2,5,5-trimethylhex-2-ene; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC.

2023FOOD AND CHEMICAL TOXICOLOGY（2023）

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