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The communication is concerned with the synthesis of phosphonic aminocarboxylic acids by phosphorylation of diethyl ω-halogen alkyl acetamidomalonates with tris(trimethylsilyl) phosphite, followed by alcoholysis and acid hydrolysis of the resulting intermediate esters.

A method is described for the synthesis of phosphorus-containing amino carboxylic acids, by the Michaelis-Bekker or Arbuzov phosphorylation of ω-haoalkylacetamidomalonic esters. The latter were obtained by alkylating the sodium salt of acetamidomalonic ester with an excess of the α,ω-dihaloalkane. Acid hydrolysis of the phosphorus-containing alkylacetamidomalonic esters gave the required compounds.