According to the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD), ultrasound (US) is the recommended tool for surveillance of patients at risk of developing hepatocellular carcinoma (HCC). Larger HCCs can be diagnosed with a high accuracy by conventional US. However, the differentiation of smaller malignant lesions in cirrhotic livers can be improved by contrast-enhanced ultrasound (CEUS). Second-generation contrast agents consisting of microbubbles enable us to visualize specific tumor vascularization patterns. With CEUS, it is not only possible to detect and characterize HCC nodules, but to control the effects of ablation techniques of HCC as well, evaluating the former lesion with respect to complete necrosis or residual viable tumor. Limitations of CEUS are its inability to characterize lesions distant to the applicator. Moreover, so far the use of contrast agents in US did not result in increased sensitivity in the detection of small HCCs (<1 cm). Thus, there is currently no indication to use contrast agents to increase the detection rate of HCC in patients undergoing US surveillance.

Wolf, M.; Ulrike, B.; Helmut, E.; Walter, M.; Uwe, H.; Ashour, M.; Frank, S.; Michael, E. Author Information

1Radiopharmaceutical Chemistry, DKFZ Heidelberg 2Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany Abstracts of the Perspectives in Melanoma X and The Third Annual International Melanoma Research Congress, 14–16 September 2006, Noordwijk, The Netherlands

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A low molecular weight endogenous substance believed to be responsible for extracellular fluid homeostasis in mammals has been sought for many years. Our goal is to isolate and structurally characterize this putative “natriuretic hormone”. We have developed an assay using the conscious rat to measure prolonged natriuresis (Benaksas et al (1993) Life Sciences, 52, 1045–1054), the activity originally described for this putative substance. Using this assay we have identified a number of natriuretic compounds isolated from human uremic urine. The collected urine is processed by ultrafiltration (≤ 3 kDa), gel filtration chromatography (G-25) and extraction with isopropanol and diethyl ether. The organic soluble material is then subjected to sequential high-performance liquid chromatography. We report here the initial characterization of two pure isolates (LLU-α and LLU-γ) obtained by this method, and the structural elucidation of a third pure compound, LLU-β1, a natriuretic and previously unreported metabolite of the drug diltiazem.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

AbstractMethylmaleinsäureanhydrid (I) bildet mit Cyclopentadien (II) das Cycloaddukt (III), das in den 1,2‐Dicarbonsäuredimethylester (IV) umgewandelt wird.

Chemischer InformationsdienstVolume 5, Issue 32 Organoelement Compounds ChemInform Abstract: SYNTHETIC ROUTES TO HALOMETHYL VINYLSILANES GILBERT STORK, GILBERT STORKSearch for more papers by this authorMICHAEL E. JUNG, MICHAEL E. JUNGSearch for more papers by this authorERNEST COLVIN, ERNEST COLVINSearch for more papers by this authorYVES NOEL, YVES NOELSearch for more papers by this author GILBERT STORK, GILBERT STORKSearch for more papers by this authorMICHAEL E. JUNG, MICHAEL E. JUNGSearch for more papers by this authorERNEST COLVIN, ERNEST COLVINSearch for more papers by this authorYVES NOEL, YVES NOELSearch for more papers by this author First published: August 13, 1974 https://doi.org/10.1002/chin.197432350AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References GILBERT STORK, MICHAEL E. JUNG, ERNEST COLVIN, YVES NOEL, SYNTHETIC ROUTES TO HALOMETHYL VINYLSILANES, J. Am. Chem. Soc., 1974, 96, 3684. DOI: 10.1021/ja00818a071; 10.1021/ja00818a071 CASWeb of Science®Google Scholar Volume5, Issue32August 13, 1974 ReferencesRelatedInformation