Multiple-breath-washout (MBW) measurements are regarded as a sensitive technique which can reflect the ventilation inhomogeneity of respiratory airways. Typically nitrogen is used as the tracer gas and is washed out by pure oxygen in multiple-breath-nitrogen washout (MBNW) tests. In this study, instead of using nitrogen, (4)He is used as the tracer gas with smaller gas density which may be able to reach deeper into our lungs in a given time and the helium washout results may be more sensitive to the ventilation inhomogeneity in small airways. A multiple-breath-helium-washout (MBHW) system developed for the lung function study is also presented. Quartz tuning forks with a resonance frequency of 32,768Hz have been used for detecting the change of the respiratory gas density. The resonance frequency of the quartz tuning fork decreases linearly with increasing density of the surrounding gas. Knowing the CO2 concentration from the infrared carbon dioxide detector, the helium concentration can be determined. Results from 14 volunteers (3 mild asthmatics, 4 tobacco smokers, 1 with asthma history, 1 with COPD history, 5 normal) have shown that mild asthmatics have higher ventilation inhomogeneity in either conducting or acinar airways (or both). A feature has been found in washout curve of single breaths from 4 tobacco smokers with different length of smoking history which may indicate the early stage of respiratory ventilation inhomogeneity in acinar airways.

We use dynamic scanning capacitance microscopy (DSCM) to image compressible and incompressible strips at the edge of a Hall bar in a two-dimensional electron gas (2DEG) in the quantum Hall effect (QHE) regime. This method gives access to the complex local conductance, Gts, between a sharp metallic tip scanned across the sample surface and ground, comprising the complex sample conductance. Near integer filling factors we observe a bright stripe along the sample edge in the imaginary part of Gts. The simultaneously recorded real part exhibits a sharp peak at the boundary between the sample interior and the stripe observed in the imaginary part. The features are periodic in the inverse magnetic field and consistent with compressible and incompressible strips forming at the sample edge. For currents larger than the critical current of the QHE break-down the stripes vanish sharply and a homogeneous signal is recovered, similar to zero magnetic field. Our experiments directly illustrate the formation and a variety of properties of the conceptually important QHE edge states at the physical edge of a 2DEG.

We use dynamic scanning capacitance microscopy to image compressible and incompressible strips at the edge of a Hall bar in a two-dimensional electron gas (2DEG) in the quantum Hall effect (QHE) regime. This method gives access to the complex local conductance, G(ts), between a sharp metallic tip scanned across the sample surface and ground, comprising the complex sample conductance. Near integer filling factors we observe a bright stripe along the sample edge in the imaginary part of G(ts). The simultaneously recorded real part exhibits a sharp peak at the boundary between the sample interior and the stripe observed in the imaginary part. The features are periodic in the inverse magnetic field and consistent with compressible and incompressible strips forming at the sample edge. For currents larger than the critical current of the QHE break-down the stripes vanish sharply and a homogeneous signal is recovered, similar to zero magnetic field. Our experiments directly illustrate the formation and a variety of properties of the conceptually important QHE edge states at the physical edge of a 2DEG.

We demonstrate a dynamic scanning capacitance microscope (DSCM) that operates at large bandwidths, cryogenic temperatures, and high magnetic fields. The setup is based on a noncontact atomic force microscope (AFM) with a quartz tuning fork sensor for the nonoptical excitation and readout in topography, force, and dissipation measurements. The metallic AFM tip forms part of a rf resonator with a transmission characteristics modulated by the sample properties and the tip-sample capacitance. The tip motion gives rise to a modulation of the capacitance at the frequency of the AFM sensor and its harmonics, which can be recorded simultaneously with the AFM data. We use an intuitive model to describe and analyze the resonator transmission and show that for most experimental conditions it is proportional to the complex tip-sample conductance, which depends on both the tip-sample capacitance and the sample resistivity. We demonstrate the performance of the DSCM on metal disks buried under a polymer layer and we discuss images recorded on a two-dimensional electron gas in the quantum Hall effect regime, i.e. at cryogenic temperatures and in high magnetic fields, where we directly image the formation of compressible stripes at the physical edge of the sample.

We investigate the local conductivity of a two-dimensional electron gas (2DEG) in the regime of the quantum Hall effect with a scanning capacitance microscope. At integer Landau level filling factors the bulk of the sample is insulating, whilst we find a well-defined narrow stripe of high local conductivity at the physical edge of the standard Hall device. Away from integer filling the conductivity of the Hall bar is homogeneous, similar to the zero field case. In addition, we discuss an anomalously broadened stripe around a locally depleted region of the 2DEG. We attribute the increased width of this stripe to a shallower potential gradient compared to the sample edge.

Multiple-breath-washout (MBW) measurements are regarded as a sensitive technique for lung function studies which can reflect the ventilation inhomogeneity of our respiratory airways [7,8,9]. Typically nitrogen is used as the tracer gas and is washed out by pure oxygen in multi-breath-nitrogen (MBNW) washout tests. In this work, instead of using nitrogen, 4He is used as the tracer gas. A commercial quartz tuning fork with a resonance frequency of f-32 kHz has been used for detecting the concentration of 4He gas at room temperature. This low-cost sensor has been used previously for detecting the gas density [11]. The resonance frequency of the tuning fork decreases linearly with increasing density of the surrounding gas and we use this effect to determine the helium concentration. The resulting washout curve from an asthmatic volunteer has smaller curve linearity compared to a normal healthy person which reflects the higher ventilation inhomogeneity of the respiratory airways.