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1Development Of [F-18]-Labeled Benzamides As Sigma Receptor Radioligands For Tumor Imaging

M. E. Van Dort, G. Kande, J. N. Rauch,C. S. John, A. Comeau,W. D. Bowen,A. Rehemtulla,B. D. Ross

2011JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS（2011）

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2Stereospecific Inhibition of Monoamine Uptake Transporters by Meta-Hydroxyephedrine Isomers.

K. F. Foley,M. E. Van Dort,M. K. Sievert,A. E. Ruoho,N. V. Cozzi

Meta-hydroxyephedrine (HED) comprises four stereoisomers consisting of two enantiomeric pairs related to ephedrine and pseudoephedrine. HED is transported into adrenergic neurons and radiolabeled HED has been employed in positron emission tomography (PET) to image adrenergic neurons in vivo. To extend structure-activity analyses of binding sites within monoamine transporters and to determine which stereoisomer displayed the best selectivity for PET imaging applications, we tested the HED compounds for their abilities to inhibit [(3)H]neurotransmitter uptake into platelets, transfected cells, and chromaffin vesicles. We hypothesized that the HED compounds would be most potent at the norepinephrine transporter (NET) compared to the serotonin or dopamine transporters and that the 1R diastereomers would be more effective than 1S diastereomers. Supporting the hypotheses, all stereoisomers were most potent at the NET and the 1R,2S stereoisomer was the most potent inhibitor overall. However, the 1S,2R isomer may be preferred for PET applications because of better selectivity among the transporters and reduced neuronal recycling.

2002Journal of Neural Transmission（2002）引用：9

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3Development of Radioiodinated Nonsteroidal Androgen Receptor Ligands for Spect Imaging of Prostate Cancer

M. E. Van Dort,Y‐W Jung,P. S. Sherman,K. K. Kuszpit

Journal of Labelled Compounds and RadiopharmaceuticalsVolume 44, Issue S1 p. S327-S329 Article Development of radioiodinated nonsteroidal androgen receptor ligands for spect imaging of prostate cancer M. E. Van Dort, M. E. Van Dort Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorY-W Jung, Y-W Jung Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorP. S. Sherman, P. S. Sherman Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorK. K. Kuszpit, K. K. Kuszpit Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this author M. E. Van Dort, M. E. Van Dort Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorY-W Jung, Y-W Jung Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorP. S. Sherman, P. S. Sherman Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorK. K. Kuszpit, K. K. Kuszpit Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this author First published: 23 April 2012 https://doi.org/10.1002/jlcr.25804401115Citations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume44, IssueS1Supplement: Journal of Labelled Compounds and RadiopharmaceuticalsMay 2001Pages S327-S329 RelatedInformation

2001Journal of Labelled Compounds and Radiopharmaceuticals（2001）引用：1

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4(±)‐N‐[11c]methyl‐para‐hydroxytranylcypromine: Synthesis and Evaluation As a Pet Radiotracer for Quantifying Cardiac Sympathetic Nerve Density

Y. W. Jung,D. L. Gildersleeve,M. E. van Dort,D. M. Raffel

Our laboratory has previously developed several radiotracers that can be used to noninvasively assess regional cardiac sympathetic nerve integrity in the living human, including radioiodinated meta-iodobenzylguanidine (MIBG) for single-photon imaging studies' and ["C]meta-hydroxyephedrine (HED) for PET imaging studies2. However, the kinetic properties of the current generation of neuronal imaging agents are not conducive to quantitative analysis with compartmental modeling techniques, which limits our ability to obtain sensitive measures of neuronal density. In an effort to develop a sympathetic nerve tracer with more favorable kinetic properties for compartmental modeling, we synthesized a "C-labeled analog of tranyl~ypromine~ (TCP), a suicide inhibitor of monoamine oxidase (MAO) that is also a substrate for neuronal uptake by the norepinephrine transporter (NET). In principle, a NET substrate that is transpoited into sympathetic neurons more slowly than HED and is . subsequently trapped intraneuronally by a rapid and irreversible binding process would possess ideal kinetic properties for absolute quantification of neuronal density.

2001Journal of Labelled Compounds and Radiopharmaceuticals（2001）

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5Synthesis of a Carbon‐11 Labeled Nonsteroidal Antiandrogen As a Potential Radioligand for Pet Imaging of Prostate Cancer

M. E. Van Dort,D. M. Jewett,Y‐W Jung,P. S. Sherman,K. K. Kuszpit

Journal of Labelled Compounds and RadiopharmaceuticalsVolume 44, Issue S1 p. S330-S332 Article Synthesis of a carbon-11 labeled nonsteroidal antiandrogen as a potential radioligand for pet imaging of prostate cancer M. E. Van Dort, M. E. Van Dort Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorD. M. Jewett, D. M. Jewett Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorY-W Jung, Y-W Jung Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorP. S. Sherman, P. S. Sherman Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorK. K. Kuszpit, K. K. Kuszpit Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this author M. E. Van Dort, M. E. Van Dort Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorD. M. Jewett, D. M. Jewett Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorY-W Jung, Y-W Jung Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorP. S. Sherman, P. S. Sherman Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this authorK. K. Kuszpit, K. K. Kuszpit Division of Nuclear Medicine Department of Radiology University of Michigan Medical School Ann Arbor, MI 48109-0552Search for more papers by this author First published: 23 April 2012 https://doi.org/10.1002/jlcr.25804401116Citations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume44, IssueS1Supplement: Journal of Labelled Compounds and RadiopharmaceuticalsMay 2001Pages S330-S332 RelatedInformation

2001Journal of Labelled Compounds and Radiopharmaceuticals（2001）引用：4

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6Synthesis and evaluation of (E)-(3-[I-125]iodoprop-2-enyl) ether derivatives of α- and β-dihydrotetrabenazine as possible radioligands for the neuronal vesicular monoamine transporter (VMAT2)

M. E. Van Dort,M. R. Kilbourn,Y. W. Jung,P. S. Sherman,D. M. Wieland

1999Journal of Labelled Compounds and Radiopharmaceuticals引用：23

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7Synthesis and in vivo evaluation of radioiodinated (+)-7- iodobenzovesamicol: A high-affinity ligand for the sigma binding site

Y. W. Jung,David L. Gildersleeve,M. E. Van Dort,David E. Kuhl,Donald M. Wieland

1994Journal of Labelled Compounds and Radiopharmaceuticals（1994）引用：23

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8Biogenic benzyl-[18F]fluorides: (1s,2s)-1-Desoxy-1-[18F]fluoro-meta- hydroxyephedrine for mapping cardiac sympathetic neurons

M. E. Van Dort,Y. W. Jung,Michael R. Kilbourn,Donald M. Wieland

1994Journal of Labelled Compounds and Radiopharmaceuticals（1994）引用：23

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9Biogenic Benzyl-[18F]fluorides: (1S,2s)-1-desoxy-1-[18f]fluoro-meta- Hydroxyephedrine for Mapping Cardiac Sympathetic Neurons

M. V. Dort, Y. Jung,M. Kilbourn, D. Wieland

1994

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10Radioiodinated presynaptic markers for GABA and dopaminergic neurons

M. E. Van Dort,David L. Gildersleeve,Donald M. Wieland

1991Journal of Labelled Compounds and Radiopharmaceuticals（1991）引用：23

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11Synthesis of Carbon-11 Labeled Analogs of Vesamicol, a Potent Inhibitor of Vesicular Uptake of Acetylcholine

G. Mulholland,Y. Jung, M. Haka,D. Gildersleeve,M. V. Dort,D. Wieland,M. Kilbourn

1991引用：23

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12Synthesis of (±)-I-125-iodobenzovesamicol - A cholinergic neuron marker

Y. W. Jung,M. E. Van Dort,D. M. Wieland

1991Journal of Labelled Compounds and Radiopharmaceuticals（1991）引用：23

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13Search for a non-metabolizable PET tracer for heart neuronal imaging

Donald M. Wieland,Karen C. Rosenspire,M. E. Van Dort,Michael S. Haka,Y. W. Jung,David L. Gildersleeve

1991Journal of Labelled Compounds and Radiopharmaceuticals引用：23

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14ChemInform Abstract: Radioiodinated Benzodiazepines: Agents for Mapping Glial Tumors.

M. E. VAN DORT,B. J. CILIAX,D. L. GILDERSLEEVE,P. S. SHERMAN,K. C. ROSENSPIRE,A. B. YOUNG,L. JUNCK,D. M. WIELAND

AbstractCoupling of the aniline derivatives (I) with the benzonitriles (II) gives the corresponding ketimines which produce the halogenated 2‐aminobenzophenones (III) upon acidic hydrolysis.

1989引用：26

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15Synthesis of [18f]phencyclidines for Glutamate Receptor Mapping

M.E. Van Dort,D.J. Yang,M.R. Kilbourn,D.J. Gole,A. Kalir,E.F. Domino,A.B. Young,D.M. Wieland

Journal of Labelled Compounds and RadiopharmaceuticalsVolume 26, Issue 1-12 p. 346-347 Symposium Abstract Synthesis of [18F]phencyclidines for glutamate receptor mapping M.E. Van Dort, M.E. Van Dort University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorD.J. Yang, D.J. Yang University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorM.R. Kilbourn, M.R. Kilbourn University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorD.J. Gole, D.J. Gole University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorA. Kalir, A. Kalir University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorE.F. Domino, E.F. Domino University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorA.B. Young, A.B. Young University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorD.M. Wieland, D.M. Wieland University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this author M.E. Van Dort, M.E. Van Dort University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorD.J. Yang, D.J. Yang University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorM.R. Kilbourn, M.R. Kilbourn University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorD.J. Gole, D.J. Gole University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorA. Kalir, A. Kalir University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorE.F. Domino, E.F. Domino University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorA.B. Young, A.B. Young University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorD.M. Wieland, D.M. Wieland University of Michigan, Ann Arbor, MI 48109, USA and Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this author First published: January 1989 https://doi.org/10.1002/jlcr.25802601150Citations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume26, Issue1-12January 1989Pages 346-347 RelatedInformation

1989Journal of Labelled Compounds and Radiopharmaceuticals（1989）引用：2

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16False Neurotransmitters; PROS and CONS As PET Tracers

D.M. Wieland,M.E. Van Dort,D.L. Gildersleeve

Journal of Labelled Compounds and RadiopharmaceuticalsVolume 26, Issue 1-12 p. 207-207 Symposium Abstract False neurotransmitters; PROS and CONS as PET tracers D.M. Wieland, D.M. Wieland University of Michigan, Division of Nuclear Medicine, Ann Arbor, MI 48109 USASearch for more papers by this authorM.E. Van Dort, M.E. Van Dort University of Michigan, Division of Nuclear Medicine, Ann Arbor, MI 48109 USASearch for more papers by this authorD.L. Gildersleeve, D.L. Gildersleeve University of Michigan, Division of Nuclear Medicine, Ann Arbor, MI 48109 USASearch for more papers by this author D.M. Wieland, D.M. Wieland University of Michigan, Division of Nuclear Medicine, Ann Arbor, MI 48109 USASearch for more papers by this authorM.E. Van Dort, M.E. Van Dort University of Michigan, Division of Nuclear Medicine, Ann Arbor, MI 48109 USASearch for more papers by this authorD.L. Gildersleeve, D.L. Gildersleeve University of Michigan, Division of Nuclear Medicine, Ann Arbor, MI 48109 USASearch for more papers by this author First published: January 1989 https://doi.org/10.1002/jlcr.2580260193Citations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume26, Issue1-12January 1989Pages 207-207 RelatedInformation

1989Journal of Labelled Compounds and Radiopharmaceuticals（1989）引用：1

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17Happing Cation Channels: Synthesis of [125I] and [18F] Analogs of MK‐801

D.M. Wieland,M.R. Kilbourn,E. Laborde,D.J. Yang,J‐L. Pirat,D.L. Gildersleeve,M.E. Van Dort,B.J. Ciliax,A.B. Young

Journal of Labelled Compounds and RadiopharmaceuticalsVolume 26, Issue 1-12 p. 10-11 Symposium Abstract Happing cation channels: Synthesis of [125I] and [18F] analogs of MK-801 D.M. Wieland, D.M. Wieland University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorM.R. Kilbourn, M.R. Kilbourn University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorE. Laborde, E. Laborde University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorD.J. Yang, D.J. Yang University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorJ-L. Pirat, J-L. Pirat University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorD.L. Gildersleeve, D.L. Gildersleeve University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorM.E. Van Dort, M.E. Van Dort University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorB.J. Ciliax, B.J. Ciliax University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorA.B. Young, A.B. Young University of Michigan, Ann Arbor, MI 48109Search for more papers by this author D.M. Wieland, D.M. Wieland University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorM.R. Kilbourn, M.R. Kilbourn University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorE. Laborde, E. Laborde University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorD.J. Yang, D.J. Yang University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorJ-L. Pirat, J-L. Pirat University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorD.L. Gildersleeve, D.L. Gildersleeve University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorM.E. Van Dort, M.E. Van Dort University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorB.J. Ciliax, B.J. Ciliax University of Michigan, Ann Arbor, MI 48109Search for more papers by this authorA.B. Young, A.B. Young University of Michigan, Ann Arbor, MI 48109Search for more papers by this author First published: January 1989 https://doi.org/10.1002/jlcr.2580260106AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume26, Issue1-12January 1989Pages 10-11 RelatedInformation

1989Journal of Labelled Compounds and Radiopharmaceuticals（1989）

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