INTRODUCTION:Evidence-based dentistry (EBD) refers to the use of the best available evidence in combination with clinical expertise and patient values to guide clinical decision-making. Whilst evidence-based medicine (EBM) is widely adopted in medicine, EBD is much less frequently used in dentistry. Research into dental students' views towards EBD is limited. Understanding the views of this group is essential to increasing adoption of EBD among the dental profession. AIM:This study assessed final-year undergraduate dentistry students' knowledge, perception, and attitudes towards EBD, and identified barriers to its routine use. METHODS:A 3-month cross-sectional study was conducted among 276 final-year dental students from eight European universities. Data were collected using an online questionnaire. RESULTS:Students demonstrated good understanding of the principles of EBD and reported positive attitudes towards EBD, recognising its value in clinical decision-making and professional development. Significant differences in knowledge around EBD were observed between countries. The most frequently reported barrier to the use of EBD was insufficient training (61.6%), followed by a lack of confidence in interpreting research findings (59.4%), and limited access to relevant journals (47.8%). CONCLUSION:Dental students acknowledge the importance of EBD, but their knowledge and skills in this area are limited. Insufficient training is the primary barrier, pointing to an urgent need for curriculum change. EBD should be integrated into undergraduate dental curricula, emphasising skills in literature search, critical appraisal, and applying evidence to clinical scenarios. Dedicated educational programmes are essential to prepare future dentists for evidence-based care.

INTRODUCTION:Multiple studies have been undertaken to assess level of knowledge on the topic of oral mucosal biopsies from a general dental practitioner perspective, but only limited data is available on undergraduate dental students' perspective. The aim of this study was to assess clinical experience and attitudes towards oral mucosal biopsies in final-year undergraduate dental students. MATERIAL AND METHODS:Online questionnaire was sent to dental students in six European countries (Croatia, France, Italy, Portugal, Spain and United Kingdom). The questionnaire assessed clinical experience, attitudes to oral biopsy, self-perceived competence, and obstacles for performing a biopsy. Multiple choice questions and 5-point Likert scale were used. RESULTS:Two hundred and ninety-three students (response rate 24% to 88%) participated in the survey. A small proportion of students (54; 21.7%) performed a biopsy during their undergraduate education, mainly in an oral medicine setting. The majority of students did not consider themselves competent in performing a biopsy. The most common listed obstacle for performing a biopsy was lack of clinical experience with oral mucosal lesions. CONCLUSION:The results suggest there is a need for more practical training in oral biopsy techniques, as well as a need for increased clinical exposure to different oral mucosal pathologies.

Introduction The aim of this study was to assess the knowledge and clinical experience of oral potentially malignant disorders (OPMDs) in undergraduate dental students in six European countries (Croatia, France, Italy, Portugal, Spain and United Kingdom) and assess student's attitude and preference to future education on the topic. A secondary aim was to identify gaps in student's knowledge and clinical practice. The study was a part of the Erasmus+ project "Oral Potentially Malignant Disorders: Healthcare Professionals Training" (Grant No: 2020-1-UK01-KA202-078917). Materials and Methods An online questionnaire was distributed to all final-year students in six partner universities. This consisted of four parts assessing: (1) knowledge on OPMDs, (2) clinical experience with this group of patients, (3) self-rated competence in the management of OPMDs and (4) preferences with regard to future education. Results Two hundred and sixty final-year dental students from six partner universities responded to the questionnaire. Response rates varied from 12% to 92% between partner universities. Significant differences in clinical experience and knowledge were found between students. Students with more clinical exposure to OPMDs rated their knowledge and competence in the management of OPMDs higher than students with less clinical experience. The majority of students were interested in future education on OPMDs, preferably via short educational videos. Conclusion The majority of students have received theoretical knowledge of OPMDs during their undergraduate studies, however, not all had clinical exposure to this group of patients. Students were open to further education on OPMDs. Important deficiencies in knowledge were identified that need to be addressed and it is anticipated that the e-learning platform and e-book that are in development by partner institutions will help to improve overall knowledge of OPMDs.

Oral DiseasesEarly View Editorial Terminology on oral potentially malignant disorders in European languages: An appraisal Luis Monteiro, Luis Monteiro Medicine and Oral Surgery Department, University Institute of Health Sciences (IUCS), UNIPRO, CESPU, Gandra, PortugalSearch for more papers by this authorBarbara Carey, Barbara Carey Oral Medicine Department, Guy's & St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorMárcio Diniz-Freitas, Márcio Diniz-Freitas orcid.org/0000-0001-5349-1091 Special Care Dentistry Unit, School of Medicine and Dentistry, University Santiago de Compostela, Santiago de Compostela, SpainSearch for more papers by this authorNiccolò Lombardi, Niccolò Lombardi orcid.org/0000-0001-8261-1179 Dipartimento di Scienze Biomediche, Chirurgiche e odontoiatriche, Università degli Studi di Milano, Milano, ItalySearch for more papers by this authorRichard Cook, Richard Cook Oral Medicine Department, Guy's & St Thomas' NHS Foundation Trust, London, UK Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UKSearch for more papers by this authorJean-Cristophe Fricain, Jean-Cristophe Fricain Oral Surgery Department, University of Bordeaux, Bordeaux, FranceSearch for more papers by this authorVlaho Brailo, Vlaho Brailo orcid.org/0000-0002-8449-871X Oral Medicine Department, School of Dental Medicine, University of Zagreb, Zagreb, CroatiaSearch for more papers by this authorJacobo Limeres, Jacobo Limeres Special Care Dentistry Unit, School of Medicine and Dentistry, University Santiago de Compostela, Santiago de Compostela, SpainSearch for more papers by this authorElena Varoni, Elena Varoni orcid.org/0000-0002-7287-2188 Dipartimento di Scienze Biomediche, Chirurgiche e odontoiatriche, Università degli Studi di Milano, Milano, ItalySearch for more papers by this authorMathilde Fenelon, Mathilde Fenelon Oral Surgery Department, University of Bordeaux, Bordeaux, FranceSearch for more papers by this authorDanica Vidović Juras, Danica Vidović Juras Oral Medicine Department, School of Dental Medicine, University of Zagreb, Zagreb, CroatiaSearch for more papers by this authorLuis Silva, Luis Silva Medicine and Oral Surgery Department, University Institute of Health Sciences (IUCS), UNIPRO, CESPU, Gandra, PortugalSearch for more papers by this authorMichael Escudier, Michael Escudier Oral Medicine Department, Guy's & St Thomas' NHS Foundation Trust, London, UK Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UKSearch for more papers by this authorVignesh Murthy, Vignesh Murthy Oral Medicine Department, Guy's & St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorSaman Warnakulasuriya, Saman Warnakulasuriya Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK The WHO Collaborating Centre for Oral Cancer, London, UKSearch for more papers by this authorRui Albuquerque, Corresponding Author Rui Albuquerque [email protected] orcid.org/0000-0002-1741-8871 Oral Medicine Department, Guy's & St Thomas' NHS Foundation Trust, London, UK Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK Correspondence Rui Albuquerque, Department of Oral Medicine, Guy's & St Thomas' NHS Foundation Trust, 22nd Floor Tower Wing, London SE1 9RT, UK. Email: [email protected]Search for more papers by this authorGiovanni Lodi, Giovanni Lodi orcid.org/0000-0002-0218-8292 Dipartimento di Scienze Biomediche, Chirurgiche e odontoiatriche, Università degli Studi di Milano, Milano, ItalySearch for more papers by this author Luis Monteiro, Luis Monteiro Medicine and Oral Surgery Department, University Institute of Health Sciences (IUCS), UNIPRO, CESPU, Gandra, PortugalSearch for more papers by this authorBarbara Carey, Barbara Carey Oral Medicine Department, Guy's & St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorMárcio Diniz-Freitas, Márcio Diniz-Freitas orcid.org/0000-0001-5349-1091 Special Care Dentistry Unit, School of Medicine and Dentistry, University Santiago de Compostela, Santiago de Compostela, SpainSearch for more papers by this authorNiccolò Lombardi, Niccolò Lombardi orcid.org/0000-0001-8261-1179 Dipartimento di Scienze Biomediche, Chirurgiche e odontoiatriche, Università degli Studi di Milano, Milano, ItalySearch for more papers by this authorRichard Cook, Richard Cook Oral Medicine Department, Guy's & St Thomas' NHS Foundation Trust, London, UK Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UKSearch for more papers by this authorJean-Cristophe Fricain, Jean-Cristophe Fricain Oral Surgery Department, University of Bordeaux, Bordeaux, FranceSearch for more papers by this authorVlaho Brailo, Vlaho Brailo orcid.org/0000-0002-8449-871X Oral Medicine Department, School of Dental Medicine, University of Zagreb, Zagreb, CroatiaSearch for more papers by this authorJacobo Limeres, Jacobo Limeres Special Care Dentistry Unit, School of Medicine and Dentistry, University Santiago de Compostela, Santiago de Compostela, SpainSearch for more papers by this authorElena Varoni, Elena Varoni orcid.org/0000-0002-7287-2188 Dipartimento di Scienze Biomediche, Chirurgiche e odontoiatriche, Università degli Studi di Milano, Milano, ItalySearch for more papers by this authorMathilde Fenelon, Mathilde Fenelon Oral Surgery Department, University of Bordeaux, Bordeaux, FranceSearch for more papers by this authorDanica Vidović Juras, Danica Vidović Juras Oral Medicine Department, School of Dental Medicine, University of Zagreb, Zagreb, CroatiaSearch for more papers by this authorLuis Silva, Luis Silva Medicine and Oral Surgery Department, University Institute of Health Sciences (IUCS), UNIPRO, CESPU, Gandra, PortugalSearch for more papers by this authorMichael Escudier, Michael Escudier Oral Medicine Department, Guy's & St Thomas' NHS Foundation Trust, London, UK Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UKSearch for more papers by this authorVignesh Murthy, Vignesh Murthy Oral Medicine Department, Guy's & St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorSaman Warnakulasuriya, Saman Warnakulasuriya Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK The WHO Collaborating Centre for Oral Cancer, London, UKSearch for more papers by this authorRui Albuquerque, Corresponding Author Rui Albuquerque [email protected] orcid.org/0000-0002-1741-8871 Oral Medicine Department, Guy's & St Thomas' NHS Foundation Trust, London, UK Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK Correspondence Rui Albuquerque, Department of Oral Medicine, Guy's & St Thomas' NHS Foundation Trust, 22nd Floor Tower Wing, London SE1 9RT, UK. Email: [email protected]Search for more papers by this authorGiovanni Lodi, Giovanni Lodi orcid.org/0000-0002-0218-8292 Dipartimento di Scienze Biomediche, Chirurgiche e odontoiatriche, Università degli Studi di Milano, Milano, ItalySearch for more papers by this author First published: 14 October 2022 https://doi.org/10.1111/odi.14405Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. REFERENCES Aguirre-Urizar, J.-M.-M., & Mosqueda-Taylor, A. (2016). Letter to the editor: Use of some inappropriate terms in Spanish in Oral Medicine and Pathology. Medicina oral, patologia oral y cirugia bucal, 21(2), e185– e186. https://doi.org/10.4317/medoral.21158 Ben Slama, L. (2010). Affections potentiellement malignes de la muqueuse buccale: nomenclature et classification. Revue de Stomatologie et de Chirurgie Maxillo-Faciale, 111(4), 208– 212. https://doi.org/10.1016/j.stomax.2010.07.007 Dicionário da língua portuguesa. (2018). Porto Editora. Johnson, N. W. (2020). Cancer biology and carcinogenesis: Fundamental biological processes and how they are deranged in oral cancer. In S. Warnakulasuriya & J. S. Greenspan (Eds.), Textbook of oral cancer: Prevention, diagnosis and management (pp. 399– 425). Springer International Publishing. Kramer, I. R., Lucas, R. B., Pindborg, J. J., & Sobin, L. H. (1978). Definition of leukoplakia and related lesions: An aid to studies on oral precancer. Oral Surgery, Oral Medicine, and Oral Pathology, 46(4), 518– 539. Monteiro, L., Mello, F. W., & Warnakulasuriya, S. (2021). Tissue biomarkers for predicting the risk of oral cancer in patients diagnosed with oral leukoplakia: A systematic review. Oral Diseases, 27(8), 1977– 1992. https://doi.org/10.1111/odi.13747 Speight, P. M., Khurram, S. A., & Kujan, O. (2018). Oral potentially malignant disorders: Risk of progression to malignancy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 125(6), 612– 627. https://doi.org/10.1016/j.oooo.2017.12.011 Warnakulasuriya, S. (2020). Oral potentially malignant disorders: A comprehensive review on clinical aspects and management. Oral Oncology, 102, 104550. https://doi.org/10.1016/j.oraloncology.2019.104550 Warnakulasuriya, S., Johnson, N. W., & Van Der Waal, I. (2007). Nomenclature and classification of potentially malignant disorders of the oral mucosa. Journal of Oral Pathology & Medicine, 36(10), 575– 580. https://doi.org/10.1111/j.1600-0714.2007.00582.x Warnakulasuriya, S., Kujan, O., Aguirre-Urizar, J. M., Bagan, J. V., González-Moles, M. Á., Kerr, A. R., Lodi, G., Mello, F. W., Monteiro, L., Ogden, G. R., Sloan, P., & Johnson, N. W. (2021). Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO collaborating Centre for Oral Cancer. Oral Diseases, 27(8), 1862– 1880. https://doi.org/10.1111/odi.13704 Warnakulasuriya, S., & Lodi, G. (2021). Oral potentially malignant disorders: Proceedings from an expert symposium. Oral Diseases, 27(8), 1859– 1861. https://doi.org/10.1111/odi.13999 Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation

Oral submucous fibrosis (OSF) is a chronic progressive condition affecting the oral cavity, oropharynx and upper third of the oesophagus. It is a potentially malignant disorder. The authors collated and analysed the existing literature to establish the overall malignant transformation rate (MTR). A retrospective analysis of medical and dental scientific literature using online indexed databases was conducted for the period 1956 to 2021. The quality of the enrolled studies was assessed by the Newcastle-Ottawa Scale (NOS). A meta-analysis using a random effects model of a single proportion was performed along with statistical tests for heterogeneity. The overall proportion of malignancy across all studies was 0.06 (95% CI, 0.02–0.10), indicating an overall 6% risk of malignant transformation across all studies and cohorts. Sub-group analyses revealed strong differences in proportion of malignancy according to ethnicity/cohort; Chinese = 0.02 (95% CI 0.01–0.02), Taiwanese = 0.06 (95% CI, 0.03–0.10), Indian = 0.08 (95% CI, 0.03–0.14) and Pakistani = 0.27 (95% CI 0.25–0.29). Overall, the MTR was 6%; however, wide heterogeneity of the included studies was noted. Geographic variations in MTR were noted but were not statistically significant. Further studies are required to analyse the difference between cohort groups.

AbstractObjectiveThe COVID‐19 pandemic resulted in a rapid shift to the use of virtual consultations in both primary and secondary care. The aim of this study was to assess patient experience of virtual consultations (telephone and video) in the Oral Medicine department during the first wave of the COVID‐19 pandemic.MethodsA validated survey was developed with the Patient Experience Team in Guy's and St Thomas' NHS Foundation Trust. A combination of previously validated questions and newly validated psychometric questions were used to design the patient feedback questionnaire. The survey was administered to all patients following their virtual (telephone or video) consultation. Data were synthesised and electronically analysed. Qualitative data were thematically analysed.ResultsA total of 115 surveys were completed. Over 82% rated their experience as good or very good and 69% preferred a virtual consultation for their next consultation. Thematic analysis of individual comments identified positive themes including convenience and positive/helpful clinical experience. Areas for development identified from thematic analysis included accessibility and clinical limitations in not undertaking a physical examination.ConclusionOverall, the patient experience of virtual consultations in Oral Medicine was positive.

This series of articles comprise of short reviews of clinical problems relevant to oral health care in the twenty-first century. The present article uses a composite of presenting case symptoms to hypothetically illustrate differential diagnoses of pain of the tongue and why there may, or may not be, links to aspects of infection of SARS-CoV-2 (COVID-19).

The Faculty of Dental Surgery of the Royal College of Surgeons of England and British Dental Journal have teamed up to provide a regular series of short articles on different aspects of clinical and academic dentistry. This series will provide concise insight into a diverse range of topics with the aim of providing regular ongoing professional development for all members of the oral healthcare team. We begin here, with a short update on the Faculty and overview of the series' aims.

An e-learning education resource on the topic of oral potentially malignant disorders Ishita Thakrar, Barbara Carey, Richard Cook, Luis Monteiro, Márcio Diniz-Freitas, Niccolò Lombardi, Jean-Cristophe Fricain, Vlaho Brailo, Jacobo Limeres, Elena Varoni, Mathilde Fenelon, Danica Vidović Juras, Luis Silva, Michael Escudier, Giovanni Lodi, Silvian Catros, Ivana Skrinjar, Raj Ariyaratnam, Bozana Loncar Brzak, Ana Andabak Rogulj, Rui Albuquerque 1 Oral Medicine Department, Guy’s & St Thomas’ NHS Foundation Trust, London, UK 2 Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, UK 3 Medicine and Oral Surgery Department, University Institute of Health Sciences (IUCS), UNIPRO, CESPU, Gandra, Portugal 4 Special Care Dentistry Unit, School of Medicine and Dentistry, University Santiago de Compostela, Spain 5 Dipartimento di Scienze Biomediche, Chirurgiche e odontoiatriche, Università degli Studi di Milano, Italy 6 Oral Surgery Department, University of Bordeaux, France 7 Oral Medicine Department, School of Dental Medicine, University of Zagreb, Croatia 8 University of Manchester, UK

British Journal of DermatologyAccepted Articles RESEARCH LETTEROpen Access Validation of an Oral Disease Severity Score for use in oral lichen planus Martyn Ormond, Martyn Ormond Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorHelen McParland, Helen McParland Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorPriya Thakrar, Priya Thakrar Department of Oral Medicine, Birmingham Dental Hospital and School of Dentistry, Birmingham, UKSearch for more papers by this authorAna Donaldson, Ana Donaldson Biostatistics and Research Methods Centre, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UKSearch for more papers by this authorManoharan Andiappan, Manoharan Andiappan Biostatistics and Research Methods Centre, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UKSearch for more papers by this authorRichard J. Cook, Richard J. Cook Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK Centre for Oral Clinical and Translational Sciences, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UKSearch for more papers by this authorMichael Escudier, Michael Escudier Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK Centre for Host-Microbiome Interactions, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UKSearch for more papers by this authorJon Higham, Jon Higham Department of Oral Medicine, Birmingham Dental Hospital and School of Dentistry, Birmingham, UKSearch for more papers by this authorEsther Hullah, Esther Hullah Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorRoddy McMillan, Roddy McMillan Department of Oral Medicine, Eastman Dental Hospital, UCLH / Eastman Dental Institute, UCL, London, UKSearch for more papers by this authorJennifer Taylor, Jennifer Taylor Department of Oral Medicine, Glasgow Dental Hospital and School, Glasgow, UKSearch for more papers by this authorPepe J. Shirlaw, Pepe J. Shirlaw Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorStephen J. Challacombe, Stephen J. Challacombe Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK Centre for Host-Microbiome Interactions, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UKSearch for more papers by this authorJane F. Setterfield, Corresponding Author Jane F. Setterfield jane.setterfield@kcl.ac.uk Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK Centre for Host-Microbiome Interactions, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UK St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK Correspondence Jane Setterfield Email: jane.setterfield@kcl.ac.ukSearch for more papers by this author Martyn Ormond, Martyn Ormond Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorHelen McParland, Helen McParland Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorPriya Thakrar, Priya Thakrar Department of Oral Medicine, Birmingham Dental Hospital and School of Dentistry, Birmingham, UKSearch for more papers by this authorAna Donaldson, Ana Donaldson Biostatistics and Research Methods Centre, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UKSearch for more papers by this authorManoharan Andiappan, Manoharan Andiappan Biostatistics and Research Methods Centre, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UKSearch for more papers by this authorRichard J. Cook, Richard J. Cook Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK Centre for Oral Clinical and Translational Sciences, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UKSearch for more papers by this authorMichael Escudier, Michael Escudier Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK Centre for Host-Microbiome Interactions, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UKSearch for more papers by this authorJon Higham, Jon Higham Department of Oral Medicine, Birmingham Dental Hospital and School of Dentistry, Birmingham, UKSearch for more papers by this authorEsther Hullah, Esther Hullah Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorRoddy McMillan, Roddy McMillan Department of Oral Medicine, Eastman Dental Hospital, UCLH / Eastman Dental Institute, UCL, London, UKSearch for more papers by this authorJennifer Taylor, Jennifer Taylor Department of Oral Medicine, Glasgow Dental Hospital and School, Glasgow, UKSearch for more papers by this authorPepe J. Shirlaw, Pepe J. Shirlaw Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UKSearch for more papers by this authorStephen J. Challacombe, Stephen J. Challacombe Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK Centre for Host-Microbiome Interactions, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UKSearch for more papers by this authorJane F. Setterfield, Corresponding Author Jane F. Setterfield jane.setterfield@kcl.ac.uk Department Oral Medicine, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK Centre for Host-Microbiome Interactions, King's College London Faculty of Dentistry, Oral & Craniofacial Sciences, London, UK St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK Correspondence Jane Setterfield Email: jane.setterfield@kcl.ac.ukSearch for more papers by this author First published: 04 January 2022 https://doi.org/10.1111/bjd.20968 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/bjd.20968 AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract - Accepted ArticlesAccepted, unedited articles published online and citable. The final edited and typeset version of record will appear in the future. RelatedInformation

Introduction: The diagnosis of and risks associated with oral potentially malignant disorders (OPMD) have been widely reported, but little has been published on the management of OPMDs in a primary dental care setting. Hospital services face ongoing pressures due to long-term follow-up, with a need for surveillance to be jointly undertaken with primary dental care clinicians. In a primary care setting, identification and surveillance of OPMDs can be challenging as no universal guidance exists on recommended recall intervals. Corpus: In this article, an update on OPMDs is provided and, based on the practices of six Oral Medicine units in Europe (London (United Kingdom), Milan (Italy), Bordeaux (France), Porto (Portugal), Zagreb (Croatia) and Santiago de Compostela (Spain)), aiming to provide guidance on monitoring in a primary care setting in Europe. Conclusion: Oral medicine clinicians can provide guidance to general dental practitioners (GDPs) on recommended recall intervals. It is important that they feel confident in monitoring these conditions and, when concerned, to arrange referral to a hospital or appropriate specialist. GDPs should document descriptions of lesions and, if possible, take clinical photographs. Patients should be counselled on modifiable lifestyle factors and directed to oral medicine society websites to access patient information leaflets.

Objective To report the clinical characteristics of the largest single centre cohort of patients with eosinophilic sialodochitis. Methods Analysis of data relating to 37 patients seen in a dedicated multidisciplinary clinic was performed. Demographic, clinical, haematological, cytological, histological and radiological features were collated. Response to trials of allergy treatment was assessed. Results Thirty-seven patients (30 female, seven male) were identified, 42% of whom were of Afro-Caribbean origin, with a mean age of 50.4 years (range 28-80 years). Mean symptom duration at presentation was 10 years (range 2-33 years). Parotid and submandibular gland involvement was equally reported. The most commonly reported symptoms were swelling (97%), itching of the overlying skin (92%), salivary gland discomfort (84%) and "string-like" mucus discharge from salivary duct orifices (76%). Twenty-three patients (62%) demonstrated atopic disease and serum IgE level elevated in 57%. All 37 patients had eosinophils present in aspirated duct contents samples while raised peripheral eosinophil count was seen in 41%. Anecdotal symptom improvement was reported with antihistamine, antileukotriene or steroid treatment. Conclusion Eosinophilic sialodochitis should be considered in any patient presenting with recurrent salivary gland swelling. Further studies are needed to evaluate treatments directed at a likely allergic pathogenesis.

Objectives The early diagnosis and monitoring of Crohn's disease (CD) and orofacial granulomatosis (OFG) might be facilitated by assaying potential disease biomarkers in saliva. Markers of oxidative stress and inflammation were assayed in salivas from patients with CD, OFG and concurrent OFG and CD (OFG + CD). Subjects Unstimulated whole mouth saliva was collected from 93 subjects, and immunoglobulin A (IgA), lactoferrin (LF) and myeloperoxidase (MPO) were determined by ELISA. Markers of oxidative stress and antioxidant status were assayed spectrophotometrically. Results Immunoglobulin A was significantly (p < .03) higher in experimental groups vs the control group. LF was significantly (p < .01) higher in OFG + CD compared to CTRL and CD. Ferric reducing antioxidant power was lower (p <= .009) in all experimental groups, and advanced glycation end products were higher (p <= .01) in CD and OFG + CD patients. Conclusion Oxidative stress is increased in saliva in CD and OFG. Although MPO, a product of inflammatory cells, was not significantly increased, the other innate immune markers, IgA and LF, which are also secreted by salivary glands, were increased. This study suggests that saliva might be utilized in monitoring CD and OFG but further longitudinal studies focused on analysing a panel of salivary markers are needed.