FC), a causa della persistente patologia ostruttiva delle vie aeree, è maggiore il rischio di sviluppare infezioni da RGM.L'aumento di prevalenza di Mycobacterium abscessus e Mycobacterium chelonae nella popolazione con Fibrosi Cistica e la loro implicazione nella malattia cronica polmonare, ci hanno indotto ad attivare specifici programmi di sorveglianza.Scopo.L'osservazione occasionale che gli RGM crescono sul terreno selettivo generalmente utilizzato per isolare Burkholderia cepacia complex (BCSA), ci ha indotti a verificare se tale terreno possa essere utilizzato per isolare

Background: Mutation spectra of the CFTR gene vary between populations.Knowledge of these mutation spectra is needed for diagnostic purposes, for counselling in CF families and for screening, either neonatal to improve prognosis, or preconceptional and prenatal to provide for reproductive options.There is only limited knowledge about the mutation spectra in migrant populations in Europe.Aims: To determine the identity and frequency of mutations found in Turkish and North-African CF patients and to determine the test-sensitivity of common CF-gene mutation panels when offering carrier screening to Mediterranean people.Methods: In a survey among 373 European CF-centres, we asked which mutations have been found among Turkish and North African CF patients.Results: Fifty mutations had been found on 75.2% (95% CI: 70.4 80.0%) of CFTR alleles of patients ( n 156) originating from Turkey or North Africa.The mean sensitivity of common CF-gene mutation panels to detect these mutations was 50.6% (95% CI: 45.0 56.2%), and differed significantly between Turkish and North-African people: 41.7% (95% CI: 34.7 48.6%) versus 66.4% (95% CI: 57.7 75.2%).A sensitivity of 63.6% (95%CI: 58.2 69.0) can be achieved by expanding the mutation panels with these Mediterranean mutations.Conclusion: A low test-sensitivity of common CF-gene mutation panels for carrier screening of Mediterranean people was observed.This raises questions on whether and how to implement CF-carrier screening in a multi-ethnic society.