Three hundred and seventy-one serum samples from 170 children with congenital or natally or post-natally acquired cytomegalovirus (CMV) infections, demonstrated by virus isolation from urine and/or saliva, were tested for specific IgM and IgA antibodies by an indirect enzyme immunoassay.

Generalized infections with YE are relatively uncommon. Iron overload has been described as a major determinant of dissemination in YE infection. Recently a flurry of clinical reports have suggested that the supply of exogenous siderophores, such as desferrioxamine B, may trigger the development of systemic Yersiniosis. We report our data based upon a 10-year continuous surveillance of human Yersiniosis in Italy. Eighty-one per cent(9/11)of YE septicemia occurred in beta-thaiassemia major children; YE peritonitis was exclusively observed in these patients(4/4). All but one cases of septicemia were associated with acute enteritis. Mesenteric adenitis was identified by laparotomy in all 4 patients with peritonitis, as well as in the last case of sepsis. Of the 13 children with generalized infection, 6 had history of splenectomy; 10 were on deferoxamine(DFX)treatment, while 3 were not. One fatal case was observed in the group on DFX treatment. Through our survey, we also received 474 human isolates recovered from fecal specimens. Only 15 of these were from betathalassemia children who were on daily treatment with subcutaneous DFX and were affected with non-septic clinical conditions, such as acute enteritis(11), abdominal discomfort(3), and mesenteric adenitis(l). In such instances, despite DFX therapy,intestinal infection did not lead to a generalized form. All isolates from the 28 thalassemic children belonged to human pathogenic strains(03 and 09). Thus our experience indicates that iron overload in itself account for the susceptibility of the human host to generalized YE infection, while DFX is only one of several factors that contribute to virulence of the organism.

A fatal case of Coxsackievirus B-6 (CBV-6) infection in a 4 1/2-year-old girl is reported. The disease was initially characterized by a severe meningoencephalitis and, successively, by the appearance of hyperglycaemia and glycosuria, concomitantly with complement-fixingislet cell antibodies (CF-ICA) and ICA, diarrhoea, electrolyte disorders, arrhythmia and decrease of the IgG levels, suggesting a multi-system involvement.

Acta PaediatricaVolume 61, Issue 5 p. 609-611 SOME EFFECTS OF RUBELLA VACCINATION ON IMMUNOLOGIC RESPONSIVENESS1 MARIO MIDULLA, MARIO MIDULLA Institute of Paediatrics, University of Rome, Rome, ItalySearch for more papers by this authorLUISA BUSINCO, LUISA BUSINCO Institute of Paediatrics, University of Rome, Rome, ItalySearch for more papers by this authorLIDIA MOSCHINI, LIDIA MOSCHINI Institute of Paediatrics, University of Rome, Rome, ItalySearch for more papers by this author MARIO MIDULLA, MARIO MIDULLA Institute of Paediatrics, University of Rome, Rome, ItalySearch for more papers by this authorLUISA BUSINCO, LUISA BUSINCO Institute of Paediatrics, University of Rome, Rome, ItalySearch for more papers by this authorLIDIA MOSCHINI, LIDIA MOSCHINI Institute of Paediatrics, University of Rome, Rome, ItalySearch for more papers by this author First published: September 1972 https://doi.org/10.1111/j.1651-2227.1972.tb15954.xCitations: 15AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Aceto, T., Mattimore, J. M. & Beckhorn, G. D.: Cortisol metabolites in children with varicella or rubcola. Abst Society for Pediatric Research, 1965. 2 Belsey, M. A.: The effect of varicella on tuberculosis. Southern M J, 58: 1584, 1965. 3 Berkovich, S. & Starr, S.: Effects of live type I poliovirus vaccine and other viruses on the tuberculin test. New Engl J Med, 274: 67, 1966. 4 Colarizi, A., Midulla, M. & Pediconi, M.: Indagini sullo stato immunitario verso la rosolia di bambini e madri nell'area di Roma. Risultati di un primo esperimento di vaccinazione. Minerva Med, 61: 1578, 1970. 5 Debrè, R. & Papp, K.: Sur la cuti-réaction tuberculinique au cours de la rougéole. Compt Rend Soc Biol, 95: 29, 1926. 6 Fiaschi, E., Naccarato, R., Fagiolo, U. & Farini, R.: Alcuni aspetti di immunità cellulare e umorale nell'epatite acuta virale. Gazz San, 41: 157, 1970. 7 Fireman, P., Friday, G. & Kumate, J.: Effect of measles vaccine on immunologic responsiveness. Pediatrics, 43: 264, 1969. 8 Lamb, G. A.: Effect of HPV-80 rubella vaccine on the tuberculin reaction. Amer J Dis Child, 118: 261, 1969. 9 Kadowaki, J., Nihira, M. & Nakao, T.: Reduction of phytohemagglutinin-induced lymphocyte transformation in patients with measles. Pediatrics, 45: 508, 1970. 10 Kravis, L. P., Gordon, J. D., Leeks, H. I. & Bhagwat, S.: Detection of tuberculin sensitivity in children by leukocyte culture. Amer J Dis Child, 115: 247, 1968. 11 Montgomery, J. R., South, M. A., Rawls, W. E., Melnick, J. L., Olson, G. R., Dent, P. B. & Good, R. A.: Viral inhibition of lymphocyte response to phytohemagglutinin. Science, 157: 1068, 1967. 12 Simons, M. J. & Jack, I.: Lymphocyte viraemia in congenital rubella. Lancet, II: 953, 1968. 13 Stewart, G. L., Parkman, P., Hopps, H. E., Douglas, R. D., Hamilton, J. P. & Meyer, H. M.: Rubella virus hemagglutination-inhibition test. New Engl J Med, 276: 554, 1967. 14 von Pirquet, C.: Das verhalten der kutane tuberkulin reaktion während der Masern. Deutsch Med Wschr, 34: 1297, 1908. Citing Literature Volume61, Issue5September 1972Pages 609-611 ReferencesRelatedInformation