On March 11, 2020, the World Health Organization recognized a new highly infectious-contagious SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection for humans as a pandemic.[1] Our tertiary care hospital of a medical university in South India started to function as hospital for COVID-19 patients on March 13, 2020. The aim of this article is to describe the clinical profile and outcomes of the end-stage renal disease patients on maintenance hemodialysis with COVID-19 disease at our center. Till December 31,2021, we had admitted and managed 15,719 COVID-19 disease patients. The overall mortality rate in all COVID-19 patients was 18.3% (2,878 deaths in 15,719 patients). We admitted all patients with end-stage renal disease (ESRD) on maintenance hemodialysis (MHD) who were –positive for SARS-CoV-2 by RT-PCR (reverse transcription polymerase chain reaction). These patients were both from our institute’s dialysis unit and patients referred to us from other dialysis centers. From March 2020 to March 1, 2021, we admitted 269 MHD patients, out of whom the patient files were available for 210 patients. From March 1, 2021 to till December 31, 2021, we admitted MHD 445 patients, out of whom the patient files were available for 385 patients. The total number of patients was 714. The patient files were available for 595 patients (83.3%). The minimum and maximum ages of the patients were 10 and 89 years, respectively[Supplementary Table 1]. The number of males was 435 (60.9%).Supplementary Table 1The etiology of ESRD comprised diabetes mellitus in 229 (38.4%) patients, hypertension in 126 (21.1%) patients, and other etiologies accounted for 240 (40.3%) patients. However hypertension was documented either at admission or during hospital stay in 392 patients. At admission, the mean systolic and diastolic blood pressures were 133.8 and 81.5 mm Hg. Majority of patients (606 out of 714/84.8%) were on MHD with an arteriovenous fistula. For 108 patients (out of 714/15.1%), femoral vein catheters were placed for these patients required initiation of MHD for the first time. In no patient, internal jugular vein catheterization was done. Out of 595 patients, noninvasive ventilation at admission was necessitated in 68 (11.4%) patients, and 253 (42.5%) patients required oxygen. However, 145 (out of 595/24.3%) patients required NIV in hospital stay (NIVh). This group included the patients transferred onto NIV from oxygen or admitted without oxygen requirement. The number of patients of ESRD on MHD with COVID-19 disease who expired in the hospital was 203 (34.1%). The age-wise mortality was compared in Supplementary Table 1. The data of the analysis of the mortality risk factors are described in Tables 1 to 2 and in Supplementary Tables 2–6. A table of comparison between the patients admitted in 2020 and 2021 is given in Supplementary Table 7.Table 1: NIV patients only versus non-NIV patientsTable 2: Risk factors for mortality: Multivariate regression analysis (variables in the equation)Supplementary Table: s 2Supplementary Table: s 3Supplementary Table: s 4Supplementary Table: s 5Supplementary Table: s 6Supplementary Table: s 7The number of deaths reported was 2,878 (18.3%) out of the total 15,719 COVID-19 disease patients managed. As of December 31,2021, the mortality percentage worldwide 1.9% and in our country was 1.38%. The mortality rate in ESRD patients on MHD with COVID-19 disease at our institution was 34.1%. We identified age, SpO2 at admission, number of dialysis sessions, total leucocyte count, neutrophils, lymphocytes, blood urea, aspartate aminotransferase (AST), alanine aminotransferase (ALT), C-reactive protein (CRP), serum ferritin, serum lactate dehydrogenase (LDH), male, diabetes mellitus, oxygen requirement at admission, NIV at admission, and NIV in hospital are significant risk factors for mortality. On multivariate analysis age, NIV in hospital stay and serum LDH remained significantly associated with mortality. We also identified that oxygen-requiring patients by non rebreather masks or simple masks, not by NIV, were 6.51 times more at risk of mortality than patients not requiring oxygen, NIV patients were 9.78 times more at risk of mortality than others, and NIV andoxygen-requiring patients were 8.621 times more at risk of mortality than patients not requiring oxygen. Non oxygen requirement at admission had a significant favorable impact on the outcome, P < 0.001 OR: 0.116 (0.07–0.178). The admission of ESRD patients on MHD was universal at our institute so as to isolate them from the non-COVID-19 ESRD patients. Therefore, the admission happened within few hours of diagnosis or onset of symptoms. The mean duration of hospital stay was 8.5 days. The median length of stay before death was six days. The length of hospital stay was reported as 11.4 days after admission by Goicoechea et al.[2] and as 12 days by Alberici et al.[3] Goicoechea et al.[2] reported that the median length of stay before death was 9.3 days. The mortality rate of hospitalized ESRD patients on MHD with COVID-19 disease in the study from Turkey was six times higher than the general population.[4] The mortality rate of COVID-19 MHD patients in a few more published studies was higher than the non dialysis COVID-19 patients. The significant risk factors for the higher mortality in the studies of our nation and the international studies are listed in Supplementary Tables 8 and 9.[S1-S12]Supplementary Table: s 8Supplementary Table: s 9Supplementary Material and Methods Supplementary tables Supplementary references Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.

Background This study presents our data on mortality in end stage renal disease (ESRD) patients on peritoneal dialysis (PD) who developed COVID-19. Materials and methods Sri Padmavathi Medical College Hospital, Sri Venkateswara Institute of Medical Sciences University, was designated the State COVID Hospital in March 2020. In a retrospective observational study, we collected the data of ESRD patients on PD and identified the risk factors for mortality. Results Prior to the pandemic, 136 patients with ESRD were on peritoneal dialysis at our Institute. Among them, 27 (19.8%) eventually developed COVID-19, and 14 of them (51.8%) died. Serum albumin levels were lower and D-dimer levels were significantly higher in deceased patients than in survivors. Discussion The mortality rate in ESRD patients on PD with COVID-19 at our institution was higher than in other published studies.

Introduction: Patients with autosomal dominant polycystic kidney disease (ADPKD) who have normal renal function (creatinine clearance, >90 ml per minute per 1.73 m(2) of body-surface area) might potentially benefit from frequent water intake that would be sufficient to reduce plasma AVP levels and decrease the average urine osmolality, bringing it closer to that of plasma. Materials and Methods: In this cross-sectional study, the patients of ADPKD, chronic kidney disease stages 1-5 were included. We formed a questionnaire on the dietary recommendation to the patients. The questions enquired whether the patients received the recommendation from the faculty and the postgraduates of the nephrology department that (a) they should consume at least 3000 mL of water per day, (b) that they should not consume coffee and tea,(c) adherence of patients to the advice of the nephrologists. Results: Of 294 patients, 142 (48.2%) did not receive any dietary recommendation. The rest 152 (51.7%) were given the appropriate dietary recommendation. Majority of the patients mentioned that they lacked the access to the water when they intend to consume. Despite the advice from the nephrologists, 95 (32.3%) failed to observe the abstinence from coffee and tea. The reason expressed for not quitting coffee and tea was the force of the habit. Conclusion: Treating doctorsfailed to inform 48% of patients the proper diet. Only 20.3% of patients consumed >3.0 litre of water per day. The demand of the agricultural work at a place away from home deprived majority of the participants of the study from the potable water.