The negative ion mass spectra of the resonant electron capture by molecules of 1,1-dichloroethylene, 1,2-dichloroethylene-cis, 1,2-dichloroethylene-trans, trichloroethylene and tetrachloroethylene have been recorded in the 0–12 eV range of the captured electron energy using static magnetic sector mass spectrometer modified for operation in the resonant electron capture regime. As a result, several novel low-intensive dissociation channels were revealed in the compounds under study. Additionally, the negative ion resonant states were recorded at approximately 3–12 eV, mostly for the first time. These resonant states were assigned to the electronically excited resonances of the inter-shell type by comparing their energies with those of the parent neutral molecules triplet and singlet electronically excited states known from the energy-loss spectra obtained by previous studies.

Powders of water-cleaned white kaolin were heated at different temperatures (200, 350, 500, 650, 800, and 950°). Changes in the internal structure of kaolin (density and crystal structure) and surface properties (specific surface area, immersion heat, and methylene blue adsorption) were investigated and compared with alterations of the in vitro hemolytic effect—a model of cell damaging effect—of kaolin dusts.

Intact and castrated female and male Wistar rats were treated with single and repeated oestrus producing doses of oestradiol benzoate, the different isomers of mestranol, oestriol and diene estriol bisacetate. The duration of the treatment was 2 and 14 days. Twenty-four hr after the last application the extent of phenazone hydroxylation, aminophenazone-N- and codeine-O-demethylation was determined with 9000 g-supernatant of the liver. The oxidative reactions were altered in different ways and to different extents though usually inhibition was observed. An increase of aminophenazone-N-demethylation activity especially after pretreatment with estradiol is notable.Geschlechtsreife Wistar-Ratten, sowohl intakte als auch kastrierte Weibchen sowie intakte Männchen, wurden mit einfachen und mehrfachen äquiöstrogenen Dosen von Östradiolbenzoat, den verschiedenen Mestranol-Isomeren, Östriol und Diënostroldiazetat 2 bzw 14 Tage behandelt. 24 h nach der letzten Applikation wurden die Phenazon-Hydroxylierung, die Aminophenazon-N- und Kodein-O-demethylierung im 9000 g- Leberüberstand bestimmt. Die oxydativen Biotransformationsreaktionen wurden in unterschiedlicher Richtung beeinflußt: Überwiegend wurde eine Hemmung beobachtet, auffällig war besonders nach Östriol-Behandlung eine Steigerung der Aktivität der Aminophenazon-N-demethylierung.

Studies carried out on the mechanism of toxicity of benzylpenicillin implicate a variety of factors such as the formation of substance with toxic effect, the modification of intestinal microbian flora or toxins produced by pathogenic microbes upon which the antibiotic exercises its effect.1–4 In the following study the role of hepatic reticulo-endothelial (RES) in the toxicity of benzylpenicillin has been studied.