Background: Abiraterone strongly inhibits androgen synthesis but may lead to an increase in mineralocorticoid hormones that may impair its long term tolerability in patients with prostate cancer. At present, the best conceivable treatment for managing the abiraterone-induced mineralocorticoid excess consists of the administration of glucocorticoid replacement at the lowest effective dose and salt deprivation. The drug dose should be modulated by monitoring blood pressure, fluid retention and potassium levels during therapy. Materials and methods: We evaluated prospectively phosphorus, calcium and potassium serum levels in 28 metastatic prostate cancer patients receveing abiraterone in pre and postchemotherapy setting. 10 out of 28 receveid zoledronic acid and calcium supplement as concomitant medication. Biochemical assessment was performed before receveing the first dose of abiraterone and every first day of every cycle. Results: All patients had potassium serum level within normal limits. Hypocalcemia G1 was present in 10% of patients not receveing zoledronic acid . 25% of patients (7/28) showed phosphate serum-low level G3 . In these patients we decided to administer a daily supplement of oral phosphorus with the resolution of the adverse event within 28 days in 6 out of 7 patients. Conclusions: To our knowledge there are no data reporting hypophosphatemia on abiraterone therapy. Patients with metastatic prostate cancer often showed anorexia, fatigue, confusion, anxiety, musculoskeletal pain, tremors. These symptoms could be related to malignancy or advanced age, owing to a combination of several factors. Severe hypophosphatemia cause the same symptomatology. Mild phosphate serum-low level does not require any treatment. However it is important that we identify the presence of moderate or severe hypophosphatemia because a rapid supplementation can result in a better tolerance of abiraterone and a better outcome of these patients.

Background: Prostate cancer is the most frequent malignant tumour in men, and the third highest cause of death from cancer. The widely recognised benefits of a multidisciplinary approach to treating cancer may be particularly important in prostate cancer, where there are so many treatment options to choose from. It offers patients the best chance of receiving high-quality medical procedures administered by a team of specialists in prostate disease, which is able to tailor treatment and observational strategies to their needs, and ensure access to specialist counselling, supportive care and rehabilitation. Material and methods: In april 2013 we began our activity as a Prostate Cancer Unit (PCU). The Unit is organised into a multidisciplinary team which devises and monitors treatment plans specific to each clinical situation. This team of specialists, which includes medical oncologists, urologists, radiotherapists, radiologists, pathologists, nuclear medicine specialists, nurses, psycho-oncologists, data managers, palliative care specialist and physical therapists, addresses the disease at each stage in order to offer personalized diagnosis, treatment, advice and rehabilitation. The PCU meets every other week in Carpi at the Medical Oncology Unit and through videoconference with the Modena Hospital Policlinico. Results: In these two years of activity, we discuss 384 cases of prostate cancer. The discussion have changed the initial proposal in 21 % of cases and have facilitate access to care. We maintened records of the patients who were discussed and from January 2014 we have ECM certification. Conclusions: The establishment of Prostate Cancer Units could provide financial savings and avoid multiple consultations,inappropriate treatments and secondary therapies. Prostate Cancer Units can deliver high-quality care to patients with prostate disease and provide for a multiprofessional management of the disease, due to the continuous interchange among different specialists and care. Our team of specialists is committed to offering the best advice to patients with prostate cancer diagnosis and looking for the most appropriate solutions in each case.

The objectives of our study were to evaluate the long-term oncological results of all cT3 PCa patients who presented at our center from 2000 to 2005. Over and understaging, together with Overall Survival (OS), Disease specific survival (DSS), and the morbidity of surgery were evaluated.

The standard treatment of renal tumours is the resection or enucleation of the tumour through open or laparoscopic surgey. However old pts are at risk and a more conservative approach may be indicated. PRA under local is an effective treatment for small renal tumors in a one day surgery setting. Also AS has been shown to be indicated in these pts. The objectives of this study were to evaluate and compare the oncological outcomes of old pts with renal tumours who received open surgery, PRA or AS and to observe side effects.

PRFA ablation of renal tumours under US has been previously reported by several groups to be effective for selected patients with contrast enhancing renal lesions. However, very few centres have reported long-term data (>7years) with this technique. The objective of this report was to evaluate the response rate and lesions modifications in time together with the fate of these high risk patients.

You have accessJournal of Urology1 Apr 2008SATURATION VS EXTENDED (EPBx) TECHNIQUE (10 cores) AS AN INITIAL PROSTATE BIOPSY (PBx) STRATEGY: RESULTS OF A PROSPECTIVE RANDOMIZED COMPARATIVE STUDY Maurizio Brausi, Giovanni G Castagnetti, Giovanni L Giliberto, Massimo M Viola, Gianluca G Simonini, Mirko M Gavioli, and Silvia S La Vecchia Maurizio BrausiMaurizio Brausi More articles by this author , Giovanni G CastagnettiGiovanni G Castagnetti More articles by this author , Giovanni L GilibertoGiovanni L Giliberto More articles by this author , Massimo M ViolaMassimo M Viola More articles by this author , Gianluca G SimoniniGianluca G Simonini More articles by this author , Mirko M GavioliMirko M Gavioli More articles by this author , and Silvia S La VecchiaSilvia S La Vecchia More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)62084-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "SATURATION VS EXTENDED (EPBx) TECHNIQUE (10 cores) AS AN INITIAL PROSTATE BIOPSY (PBx) STRATEGY: RESULTS OF A PROSPECTIVE RANDOMIZED COMPARATIVE STUDY." The Journal of Urology, 179(4S), p. 715 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 715 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Maurizio Brausi More articles by this author Giovanni G Castagnetti More articles by this author Giovanni L Giliberto More articles by this author Massimo M Viola More articles by this author Gianluca G Simonini More articles by this author Mirko M Gavioli More articles by this author Silvia S La Vecchia More articles by this author Expand All Advertisement PDF downloadLoading ...

You have accessJournal of Urology1 Apr 2008DEDICATED TEACHING PROGRAMS (DTP) CAN IMPROVE THE QUALITY OF TUR OF NON MUSCLE INVASIVE BLADDER TUMORS (NMIBT): EXPERIENCE OF A SINGLE INSTITUTION Maurizio Brausi, Mirko M Gavioli, Giancarlo G Peracchia, Massimo M Viola, Giovanni L Giliberto, Gianluca G Simonini, Giuseppe G De Luca, Alessandro A Borelli, Vincenzo V Bertoni, and Giorgio G Verrini Maurizio BrausiMaurizio Brausi More articles by this author , Mirko M GavioliMirko M Gavioli More articles by this author , Giancarlo G PeracchiaGiancarlo G Peracchia More articles by this author , Massimo M ViolaMassimo M Viola More articles by this author , Giovanni L GilibertoGiovanni L Giliberto More articles by this author , Gianluca G SimoniniGianluca G Simonini More articles by this author , Giuseppe G De LucaGiuseppe G De Luca More articles by this author , Alessandro A BorelliAlessandro A Borelli More articles by this author , Vincenzo V BertoniVincenzo V Bertoni More articles by this author , and Giorgio G VerriniGiorgio G Verrini More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61802-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "DEDICATED TEACHING PROGRAMS (DTP) CAN IMPROVE THE QUALITY OF TUR OF NON MUSCLE INVASIVE BLADDER TUMORS (NMIBT): EXPERIENCE OF A SINGLE INSTITUTION." The Journal of Urology, 179(4S), pp. 615–616 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 615-616 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Maurizio Brausi More articles by this author Mirko M Gavioli More articles by this author Giancarlo G Peracchia More articles by this author Massimo M Viola More articles by this author Giovanni L Giliberto More articles by this author Gianluca G Simonini More articles by this author Giuseppe G De Luca More articles by this author Alessandro A Borelli More articles by this author Vincenzo V Bertoni More articles by this author Giorgio G Verrini More articles by this author Expand All Advertisement PDF downloadLoading ...

Despite radical surgery or radical RT the long term survival of patient with PT3-T4 transitional cell carcinoma (TCC) of the bladder is rather poor. Preoperative RT followed by radical C has been advocated by many authors in pts with locally advanced bladder cancer. The objectives of this retrospective study were to evaluate the 5 and 10 year disease specific survival (DSS) of patients treated with preop RT +C or C alone to assess the recurrence rate and side effects.

BCG is considered the treatment of choice for patients with CIS of the bladder with a response rate of 70-80%. However side effects are consistent. In order to reduce toxicity low dose BCG has been proposed in intermediate-high risk patients with controversial results. The objectives of this study were to evaluate the efficacy of reduced dose BCG (75 mg Pasteur strain) in CIS of the bladder and to assess toxicity in the long run.

The objective of this study was to evaluate if an elevated serum PSA could be related also to proctological disorders in patients with a previous negative prostate biopsies.