Objective To analyze the change and clinical significance of serum ischemia modified albumin(IMA) level in patients with dilated cardiomyopathy.Methods From January 2015 to January 2017 in the Affiliated Hospital of Hebei University of Engineering,a total of 55 patients with dilated cardiomyopathy were selected as observation group,meanwhile 40 healthy people admitted to this hospital for physical examination were selected as control group.Family history of heart disease, serum levels of IMA,BNP and hs-CRP,LVEF and blood lipids index were compared between the two groups,serum levels of IMA,BNP and hs-CRP,and LVEF were compared in dilated cardiomyopathy patients with different NYHA grades,meanwhile correlations of serum IMA level with serum levels of BNP and hs-CRP,and LVEF were analyzed by Pearson correlation analysis. Results Proportion of patients with family history of heart disease,serum levels of IMA,BNP and hs-CRP in observation group were statistically significantly higher than those in control group,while LVEF,TC,HDL and LDL in observation group were statistically significantly lower than those in control group(P<0.05);no statistically significant differences of LDL/HDL ratio was found between the two groups(P>0.05).Serum levels of IMA,BNP and hs-CRP in dilated cardiomyopathy patients withⅢ- or Ⅳ-NYHA grade were statistically significantly higher than those in dilated cardiomyopathy patients with Ⅱ-NYHA grade,while LVEF in dilated cardiomyopathy patients withⅢ- or Ⅳ-NYHA grade was statistically significantly lower than that in dilated cardiomyopathy patients with Ⅱ-NYHA grade(P<0.05);serum levels of IMA,BNP and hs-CRP in dilated cardiomyopathy patients with Ⅳ-NYHA grade were statistically significantly higher than those in dilated cardiomyopathy patients with Ⅲ -NYHA grade,while LVEF in dilated cardiomyopathy patients with Ⅳ -NYHA grade was statistically significantly lower than that in dilated cardiomyopathy patients withⅢ-NYHA grade(P<0.05).Pearson correlation analysis results showed that,serum IMA level was positively correlated with serum levels of BNP(r=0.543) and hs-CRP(r=0.718) in patients with dilated cardiomyopathy,respectively(P<0.05),was negatively correlated with LVEF(r=-0.388,P<0.05).Conclusion Serum IMA level is significantly increased in patients with dilated cardiomyopathy,and it is closely correlated with cardiac function and inflammatory reaction.