Anaphylaxis is a severe, life-threatening systemic hypersensitivity reaction, triggered by variable allergic and nonallergic exposures. 1 Adkinson NF, Bochner BS, Burks AW, et al. Middleton's Allergy: Principles and Practice: Eighth Edition.2013. Available at: https://research.monash.edu/en/publications/middletons-allergy-principles-and-practice-eighth-edition. Accessed July 1, 2021. Google Scholar Here, we report a case of recurrent anaphylaxis coinciding with flares of chronic cholecystitis. We hypothesize that in rare cases, inflammatory mediators released during episodes of cholecystitis can trigger anaphylaxis.