Organic compounds with a low thermal stability and a low volatility have become accessible to mass spectrometry by analysing the secondary ions (SI) which are emitted during bombardment with ions or neutrals from the solid substance deposited on a substrate (e.g. Ag) [1–3] or from solutions in a low volatile liquid (e.g. glycerol) [4]. As characteristic ions (M+H)+ and (M−H)− (M: molecule) and in case of salts the anions and cations are observed. Furthermore the SI-spectra exhibit ions due to attachment of atoms or molecules originating from the substrate (e.g. (M+Na)+, (M+Ag)+ or (M+H+glycerol)+) and fragmentary ions.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSecondary ion mass spectrometry of folic acid analogsA. Eicke, V. Anders, M. Junack, W. Sichtermann, and A. BenninghovenCite this: Anal. Chem. 1983, 55, 2, 178–182Publication Date (Print):February 1, 1983Publication History Published online1 May 2002Published inissue 1 February 1983https://pubs.acs.org/doi/10.1021/ac00253a004https://doi.org/10.1021/ac00253a004research-articleACS PublicationsRequest reuse permissionsArticle Views207Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The detection and identification of involatile, thermally labile organic compounds in complex solutions play an important role in biology and medicine. Obviously SIMS is a very effective technique for the analysis of these organic compounds. Parent ions and characteristic fragment ions in the spectra enable detection, identification and structural information for extremely small amounts of material down to the subnanogram range. Possible interferences in the spectra, however, demand a pre-separation of complex mixtures by liquid chromatography S are possible.
AbstractRecently developed new techniques of ion formation from organic solids may become very useful in the application of mass spectrometers as detector units in liquid chromatography. Details of a liquid chromatograph mass spectrometer coupling device are presented. Some features of this device, combined with a quadrupole secondary ion mass spectrometer, are demonstrated experimentally by the analysis of aqueous solutions of leucine and cytosine. It is demonstrated that the sensitivity of the liquid chromatography secondary ion mass spectrometry combination covers the concentration range occurring in liquid chromatography.
Ion impact induced surface self-diffusion is studied with a field electron microscope using a new phenomenon, the matter transport of this diffusion caused by capillary forces. Studied is the blunting of the edges of a tungsten crystal by helium ion impact. The order of the coefficient Di describing this diffusion is determined. Di is about 106 smaller than estimated by Dranova and Mikailovski. The influence of the ion impact surface roughening is discussed.
