In the 1960s and '70s, humanity entered space to explore its novel environment. In the '80s and '90s, human presence In space focused on experiments which probe larger scientific boundaries. The decades ahead should see manned space exploited for economic benefit. But the structures that served the space program well for exploration and experimentation may not meet the needs of commercial exploitation. Commercial users of ISS will demand low cost, short timelines, and assured access for the services which they purchase. Space activities must be integrated into the normal flow of international commerce. This paper discusses what potential commercial customers expect from their use of space. It highlights the differences between what exists and what is needed, and outlines an approach to transitioning to a system which can mesh with the established mechanism of industrial capitalism. Commercial manned space will be considered successful only when sending work to laboratory based in space is as unremarkable as sending it to a laboratory in another city.