Drugs used in disease treatment can cause damage to both malignant and normal tissue. This toxicity limits the maximum therapeutic dose. Drug targetting is of high interest to increase the therapeutic efficacy of the drug without increasing systemic toxicity. Certain tissue abnormalities, disease processes, cancers, and infections are characterized by high levels of activity of specific extracellular and/or intracellular proteases. Abnormally high activity levels of specific proteases are present at sites of physical or chemical trauma, blood clots, malignant tumours, rheumatoid arthritis, inflammatory bowel disease, gingival disease, glomerulonephritis, and acute pancreatitis. Abnormal protease activity is suspected in development of liver thrombosis, pulmonary emphysema, atherosclerosis, and muscular dystrophy. Inactivating disease-associated proteases by the administration of appropriate protease inhibitors has had limited success. Instead, one could use such proteases to target drugs to treat the condition. Protease mediated drug delivery offers such a possibility. Solubilizing groups are attached to insoluble drugs via a polypeptide chain which is specifically cleavable by certain proteases. When the solubilized drug encounters the protease, the solubilizing moieties are cleaved, and the drug precipites at the disease location. Thus, a smaller systemic dosage could result in a therapeutic drug concentration at the treatment site with less systemic toxicity.
Thomas H. Epps III合作论文数Center for Research in Soft matter and Polymers, University of Delaware;Department of Chemical & Biomolecular Engineering, College of Engineering, University of Delaware;Lignolix, LLC1
Prasad Dhurjati合作论文数1maciek r antoniewicz合作论文数1yushan yan合作论文数1Matt Doty合作论文数1
April M. Kloxin合作论文数Center for Hybrid, Active, and Responsive Materials, University of Delaware;Department of Chemical and Biomolecular Engineering, College of Engineering, University of Delaware;Department of Materials Science and Engineering, University of Delaware1
Abraham M. Lenhoff合作论文数Department of Chemical & Biomolecular Engineering, College of Engineering, University of Delaware1
Norman J. Wagner合作论文数Department of Chemical and Biomolecular Engineering, College of Engineering, University of Delaware1
Claire Gmachl合作论文数Department of Electrical and Computer Engineering, School of Engineering and Applied Science, Princeton University1
Eleftherios T. Papoutsakis合作论文数Department of Chemical & Biomolecular Engineering, College of Engineering, University of Delaware1
Michael T. Klein合作论文数Department of Chemical and Biomolecular Engineering, University of Delaware1Dionisios G. Vlachos合作论文数1
Stanley I Sandler合作论文数Department of Chemical & Biomolecular Engineering, College of Engineering, University of Delaware1Peter J. Mouginis-Mark合作论文数1Christopher J. Roberts合作论文数1A. T. Charlie Johnson合作论文数1
David W Colby合作论文数Department of Chemical Engineering, Massachusetts Institute of Technology1
Curt A. Richter合作论文数Nanoscale Device Characterization Division, Physical Measurement Laboratory, National Institute of Standards and Technology1Robert Birkmire合作论文数1
Douglas J. Buttrey合作论文数Center for Catalytic Science and Technology, University of Delaware1James C. Kennedy合作论文数1
Alexander Andrianov合作论文数Department of The High Energy and Elementary Particles Physics, Saint Petersburg State University1
Kelvin H. Lee合作论文数Department of Chemical & Biomolecular Engineering, College of Engineering, University of Delaware;National Institute for Innovation in Manufacturing Biopharmaceuticals1
Arthi Jayaraman合作论文数Department of Chemical & Biomolecular Engineering, College of Engineering, University of Delaware;Department of Materials Science and Engineering, College of Engineering, University of Delaware1Mike Klopf合作论文数1Henry Leighton合作论文数1
John S. Suehle合作论文数National Institute of Standards and Technology1Boon Ooi合作论文数1Jeya Padmanaban合作论文数1
Eva F Gudgin Dickson合作论文数1
Christopher J. Kloxin合作论文数Engineering Center, University of Colorado1Scott K. Rowland合作论文数1L AINA合作论文数1Steve Fonash合作论文数1Richard P Wool合作论文数1
Antony N. Beris合作论文数Department of Chemical and Biomolecular Engineering, College of Engineering, University of Delaware1
Roy H. Pottier合作论文数Department of Chemistry and Chemical Engineering, Royal Military College of Canada1
