A series of N-(pyrimidin-4-yl)-phenylalanine VLA-4 antagonists is described. Optimization of substituents at the 2 and 5 positions of the pyrimidine ring gave 14, a very potent VLA-4 inhibitor which is orally active in a sheep asthma model.
We have surveyed all community mental health centers (CMHC's), state departments of mental health, and university departments of psychiatry in the country to ascertain the status of their relationships with one another. The response rate to a one page questionnaire was 33%.
Stephen B. Freedman合作论文数1Andrei W. Konradi合作论文数1anna liao合作论文数1Linda Chen合作论文数1Mutter Linda合作论文数1Mark L. Dreyer合作论文数1Eugene D. Thorsett合作论文数1Elizabeth J. Holsztynska合作论文数1Francine S. Farouz合作论文数1Michael A. Pleiss合作论文数1Ying-Zi Xu合作论文数1Ted Yednock合作论文数1Christopher M. Semko合作论文数1Darren B. Dressen合作论文数1Christopher Vandevert合作论文数1John A. Talbott合作论文数Payne Whitney Psychiatric Clinic, Cornell Medical Center1Judevin Lugar合作论文数1
Thomas Edward Thompson合作论文数1Jose D. Arana合作论文数1Whitney Dunn合作论文数1Kevin P. Quinn合作论文数1
