than the physiological pressures in all groups. At all time points, stapled anastomoses resisted higher intraluminal pressures than glued ones. However, glued anastomoses resisted pressures significantly higher than physiological pressure. As healing advanced, glued anastomoses neared the resistance to intraluminal pressures of stapled anastomoses. Conclusions: The results of this study suggest that the use of suitable absorbable synthetic glues is associated with healing that is equally good as that of a stapled anastomosis. Glued anastomoses were resistant to lower intraluminal pressures than stapled anastomoses, but resisted statistically significantly higher pressures than the physiological intraluminal pressures in the colon.