Newin situ(U–Th–Sm)/He and U–Pb zircon double dating method replicates results obtained using conventional methods at the Ellendale diamond occurrence.

In this paper a compartmental modelling approach is applied to provide a mathematical description of the activity of the anti-cancer agent topotecan, and delivery to its nuclear DNA target following administration. The activity of topotecan in defined buffers is first modelled using a linear two compartment model that then forms the basis of a cell based model for drug activity in live cell experiments. An identifiability analysis is performed before parameter estimation to ensure that the model output (i.e., continuous, perfect and noise-free data) uniquely determines the parameters. Parameter estimation is performed using experimental data which offers concentrations of active and inactive forms of topotecan from high performance liquid chromatography methods.

In this paper, a compartmental model is proposed for describing the in vitro kinetics of the anti-cancer agent topotecan following administration into a culture medium containing human lymphoma cells in suspension. The model extends one previously proposed by including an extra dissociation pathway, with the objective of describing the effect of DNA binding on the stability of bound topotecan. The structural identifiability and steady states of the model are analysed. The model is fitted to high performance liquid chromatography data and it is found that there is a qualitative difference between the predicted behaviour of the new model and that of the previous model.