Angioedema is a pathologic condition first described by Quincke 1 Quincke H.I. Über akutes umschriebenes Hautödem. Monatsh Prakt Dermatol. 1882; 1: 129 Google Scholar and Osler. 2 Osler W. Hereditary angioneurotic edema. Am J Med Sci. 1888; 95: 362 Crossref Google Scholar It can be genetically determined or acquired, and it is caused by a vascular reaction induced by deficiency or functional alteration of the C1 inhibitor (C1-INH), an enzyme involved in the regulation of complement, contact, fibrinolytic, and coagulation systems. 3 Ogbureke K.U.E. Cruz C. Johnson J.V. et al. Perioperative angioedema in a patient on long-term angiotensin-converting enzyme (ACE)-inhibitor therapy. J Oral Maxillofac Surg. 1996; 54: 917 Abstract Full Text PDF PubMed Scopus (26) Google Scholar , 4 Davis A.E. The pathophysiology of hereditary angioedema. Clin Immunol. 2005; 114: 3 Crossref PubMed Scopus (206) Google Scholar , 5 Turner M.D. Oughourli A. Heaney K. et al. Use of recombinant plasma kallikrein inhibitor in hereditary angioedema: A case report and review of the management of the disorder. J Oral Maxillofac Surg. 2004; 62: 1553 Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar