It has been reported the synthesis, examination of the stereochemistry and biological effect of 2-substituted-cis-5,6-trimethylen-, cis- and trans-5,6-tetramethylene and -5,6-pentamethylene-2,3,5,6-tetrahydro-1,3-oxazine-4-one derivatives. Primarily cis-isomers were synthetized because in the pharmacological test systems the trans isomers were less active. The compounds tested have an antiphlogistic effect of different intrinsic activity.

AbstractDurch Kondensation der homologen cis‐ und trans‐2‐Hydroxy‐1‐cycloalkancarboxamide (I) mit den Aldehyden (II) werden anellierte 1,3‐Oxazinone (III) hergestellt.