Group A streptococci and enterococci can be differentiated from other streptococci by their ability to cleave pyrrolidonyl beta-naphthylamide (PYRase). We evaluated two PYRase systems [Strep-A-Chek (SAC), E-Y Laboratories, San Mateo, CA; Strep-A-Fluor (SAF), BioSpec, Inc., Dublin, CA) for the presumptive identification of enterococci. Initially, 40 enterococcal and 21 nonenterococcal streptococci were tested, retrospectively. A prospective comparison of SAC and SAF to bile-esculin reaction (BE) was then incorporated into our routine procedure for the identification of non-beta-hemolytic streptococcal colonies from cultures. All isolates were speciated using standard biochemical tests. We encountered 85 enterococcal and 26 nonenterococcal isolates. Tests were performed on colonies from primary plates whenever possible (77 isolates). Sensitivity and specificity of both SAC and SAF were greater than 96% in identifying enterococci from routine cultures. These PYRase tests were cost-effective, easily adaptable to work-flow, and yielded results within 30 min. Thus, PYRase testing appears to be a reasonable alternative for the identification of enterococci in the clinical laboratory.

A small group of patients who had been sucessfully treated with lithium for a number of years were treated with zimeldine in order to determine whether this antidepressant could be substituted for lithium in patients with a bipolar affective illness. The proposed treatment period of 6 months was not reached by any patient due to depression, hypomania, mania or unusual adverse symptoms. The results of this pilot study suggest that bipolar patients being treated with lithium should not then be treated by antidepressants including those which are potent and selective inhibitors of 5-HT uptake.

A computer system that enhances the efficiency of a hospital transfusion service is described. It reduces the possibility of clerical errors; shortens the time elapsed between the ordering and the delivery of blood products; decreases the outdating of these units; and provides easy access to medical, demographic, and statistical information.

Rats with electrodes implanted in the ventral tegmentum and posterior hypothalamus were trained to press a lever to obtain electrical stimulation through the electrodes. Stimulation in animals with ventral tegmental electrodes led to an increased concentration of homovanillic acid and dihydroxyphenylacetic acid in the forebrain of the animals. Stimulation in the posterior hypothalamus did not result in such raised concentrations in spite of the fact that the behaviour from the two sites was indistinguishable. Responding in the posterior hypothalamus was reduced by doses of neuroleptic drug similar to those reported to reduce responding in the ventral tegmental area.

Subsequent of their achieving stable rates of responding for electrical stimulation through electrodes implanted in the region of the brachium conjunctivum, rats were anaesthetized and 6-hydroxydopamine injected through an implanted guide tube into the area of lateral hypothalamus in which the ascending axons of dopamine-containing neurones are found. The resultant destruction of these axons had similar temporary effects on the behaviour of the animals whether it was ipsilateral or contralateral to the electrode. It is concluded that nigral or mesolimbic dopaminergic systems are not involved in pontine intracranial self-stimulation behaviour.

AbstractDie Synthese von Cepharadion (II) aus Dehydronuciferin (I) wird beschrieben.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKrukovine, a new bis(benzylisoquinoline) alkaloid from Abuta splendidaJose M. Saa, M. V. Lakshmikantham, Michael J. Mitchell, and Michael P. CavaCite this: J. Org. Chem. 1976, 41, 2, 317–319Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/jo00864a029https://doi.org/10.1021/jo00864a029research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Chemischer InformationsdienstVolume 6, Issue 50 Natural Products ChemInform Abstract: PANURENSINE AND NORPANURENSINE, NEW BISBENZYLISOQUINOLINE ALKALOIDS FROM ABUTA PANURENSIS M. P. CAVA, M. P. CAVASearch for more papers by this authorJ. M. SAA, J. M. SAASearch for more papers by this authorM. V. LAKSHMIKANTHAM, M. V. LAKSHMIKANTHAMSearch for more papers by this authorM. J. MITCHELL, M. J. MITCHELLSearch for more papers by this author M. P. CAVA, M. P. CAVASearch for more papers by this authorJ. M. SAA, J. M. SAASearch for more papers by this authorM. V. LAKSHMIKANTHAM, M. V. LAKSHMIKANTHAMSearch for more papers by this authorM. J. MITCHELL, M. J. MITCHELLSearch for more papers by this author First published: December 16, 1975 https://doi.org/10.1002/chin.197550446Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume6, Issue50December 16, 1975 RelatedInformation

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPanurensine and norpanuresine, new bisbenzylisoquinoline alkaloids from Abuta panurensisMichael P. Cava, J. M. Saa, M. V. Lakshmikantham, and M. J. MitchellCite this: J. Org. Chem. 1975, 40, 18, 2647–2649Publication Date (Print):September 1, 1975Publication History Published online1 May 2002Published inissue 1 September 1975https://pubs.acs.org/doi/10.1021/jo00906a016https://doi.org/10.1021/jo00906a016research-articleACS PublicationsRequest reuse permissionsArticle Views112Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

NMR parameters were determined for benzocyclobutene, six substituted benzocyclobutenes and biphenylene. Values calculated for the dihedral angles between the benzylic CH bonds of benzocyclobutene indicate that the four-membered ring is skewed. Analysis of the NMR spectrum of biphenylene shows the presence of two (and not three) ring currents.