Conformational energy (A-value) of the 4-phenyl-1,2,3- triazolyl group was estimated as 2.0 kcal mol–1 (8.5 kJ mol–1) using 1H NMR-based conformational study for a set of (4-phenyl-1,2,3-triazol-1-yl)cyclohexanes. This provides a reasonable estimation also for the conformational energy of 1,2,3-triazolyl group itself and its substituted analogues.

A series of trans-2-(azaarylsulfanyl)cyclohexanol derivatives, structurally similar to previously studied trans-2-amino-cyclohexanols, were synthesized through epoxide ring opening under basic conditions with sodium tetraborate as a catalyst. 1H NMR spectroscopy was used to elucidate the conformational equilibrium in various solvents and its acid-induced change due to stabilization of the conformer with the azaarylsulfanyl and hydroxy groups in equatorial position by an intramolecular hydrogen bond and electrostatic interactions.