This paper presents the application of fixed frequency (or indirect) Sliding Mode Control (SMC) to the DC-DC Single-Ended Primary Inductor Converter (SEPIC) where the switching frequency is in the range of hundreds of kHz and consequently a FPGA is required. Due to the constraint of EPGA, only the output voltage is measured. As the proposed SMC requires the knowledge of all the states, an extended Kalman observer is introduced to estimate the state vector and the load variation. A multi-bit second-order Δ-Σ modulator is used to effectively achieve 11-bit resolution at high-frequency through only a 8-bit hardware Core Digital Pulse Width -Modulator (DPWM). Simulation and experimental studies are conducted for a laboratory prototype with switching frequency of 500 kHz. Results proved the performance of the proposed solution.